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JP2021093995A |
To provide a composition for ameliorating obesity with excellent obesity-ameliorating effect, and a composition for ameliorating type II diabetes with excellent type II diabetes-ameliorating effect.A composition for ameliorating obesity ...
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JP2021020954A |
To provide a carnosine dipeptidase 1 inhibitor composition, a use for a material that inhibits carnosine dipeptidase 1, and a method for inhibiting carnosine dipeptidase 1.A composition for inhibiting carnosine dipeptidase 1 containing p...
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JP6820251B2 |
An antimicrobial peptide and an antimicrobial peptide composition comprising the same are provided. The antimicrobial peptide and the antimicrobial peptide composition have remarkably high antibacterial activity against gram-positive (+)...
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JP6806686B2 |
The present invention pertains to a proliferation agent for increasing, or causing the proliferation of, beneficial intestinal bacteria (primarily, bifidobacteria and/or lactobacilli), the proliferation agent being characterized by conta...
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JP6730949B2 |
The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body ha...
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JP6715856B2 |
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to ...
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JP6712383B2 |
The present invention provides a method for simply isolating exosomes from a sample containing exosomes. The present invention includes a complex forming step of forming a complex by binding an exosome in a sample to a particular peptide...
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JP2020513766A |
Peptide nucleic acid derivatives that target the 3'splice site of human SNAP25 premRNA are provided. Peptide nucleic acid derivatives are useful for potently inducing at least splice variants of human SNAP25 mRNA in cells and safely trea...
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JP2020500943A |
The present disclosure relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, of formula (I), n, R.1,R1’,R2,R3,R4,R4’And R5~R14Is defined herein. The compounds of formula (I) can be used to treat bacteri...
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JP2019537576A |
A method of treating a lysosomal storage disorder in a mammal, comprising the step of administering AAV particles encoding a polypeptide into the mammalian central nervous system is provided. AAV particles can be delivered to the brain, ...
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JP6622079B2 |
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JP2019528072A |
The application specifically provides a fusion protein containing a polypeptide, which comprises a fragment of an invariant chain ligated to function on an antigen sequence, the invariant chain fragment being SEQ ID NO: It consists of a ...
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JP2019141098A |
To provide a technique to fix and preserve cell morphology of a biological sample (for example, tissue block, cancer biopsy, and whole blood).The present invention provides a deep eutectic solvent containing N, N, N-trimethylglycine and ...
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JP6568193B2 |
The present invention relates to a polypeptide comprising an epitope of an antigen; a kit and a composition for use in the diagnosis of allergy, wherein the kit and the composition comprise the aforementioned polypeptide, and a method fo...
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JP2019520822A |
The present specification provides a meniscal implant composition and a method for making and using it. This meniscal implant is used to repair and / or replace damaged or affected meniscal tissue in a mammalian subject. [Selection diagr...
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JP6496322B2 |
The present invention relates to detecting cleavage activity of an enzyme. The various aspects of the invention include an enzyme detection device, kit, method and use for detecting or measuring the presence in a test sample of the activ...
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JP6480865B2 |
The invention relates to disulfide-rich dimer molecules which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4β7 binding.
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JP6462100B2 |
To provide a novel substance or composition that is safe and shows excellent ACE inhibition.The present invention provides a composition obtained by treating rice bran with thermolysin or chymotrypsin.SELECTED DRAWING: None
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JP6440342B2 |
The present invention relates to anex vivouse of a lytic peptide or lytic peptidomimetic for the prevention of biofilm formation on a solid support, wherein said peptide or peptidomimetic a) carries a net charge of at least plus 2; b) is...
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JP6433001B2 |
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand-targeted amphipathic membrane active polyamines reversibly mod...
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JP6421310B2 |
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JP6415547B2 |
The present invention relates to a composition, a kit and a method for diagnosing pancreatic cancer, comprising an agent for measuring a protein or mRNA expression level of a certain marker gene available for determining the onset or the...
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JP2018529652A |
Manipulated and modified Cry6Aa insecticidal toxins, polynucleotides encoding the toxins, use of the toxins to control pests, and transgenic plants that produce the toxins are disclosed. [Selection diagram] Fig. 2
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JP2018143137A |
To provide peptide aptamers, peptides and polysaccharide detection reagents that are easy to synthesize and have specific binding properties to one or more types of polysaccharides.The peptide aptamer has specific affinity to at least on...
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JP2018521994A |
Peptides that are homing, distributed, targeted, directed, or accumulated in tumors, cancers, or pathogenic cells are disclosed. Peptides that cross the blood-brain barrier and accumulate in the brain and in specific areas of the brain a...
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JP2018519247A |
Provided herein are compounds and pharmaceutical compositions that include an EphA4 inhibitor. EphA4 inhibitors and their compositions are useful in the treatment of ALS. [Selection diagram] Fig. 3A
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JP6358933B2 |
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JP2018514512A |
In the present invention, the equation X is contained in the e1 loop.pZqXrA protein containing the hepatitis B core antigen (HBcAg) having the sequence of, X is a negatively charged amino acid residue, Z is a positively charged amino aci...
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JP2018512446A |
The modified peptide AT-01 was synthesized from the microbial flora secretory protein MPT63 of Mycobacterium tuberculosis. This peptide (about 30 amino acids) contains part of the immunogenic region of MPT63 (131 amino acids). This pepti...
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JP6308593B2 |
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JP6306197B2 |
The present invention provides a manufacturing method of a hydrolysate of animal protein, comprising: primarily removing fat from a source of the animal protein; and hydrolyzing a resultant product with a protease under a high pressure. ...
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JP2018038437A |
To provide a novel process and a composition using a viral capsid protein resistant to hydrolase in order to encapsulate nucleic acids, such as siRNA and shRNA, as well as a target cargo molecule of interest including small peptides and ...
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JP2018016629A |
To provide a proteasome inhibitor, FAP-activated prodrug of proteasome inhibitor, and pharmaceutically acceptable salts of the inhibitor and prodrug, and to provide a related pharmaceutical composition, and methods of using the inhibitor...
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JP6223132B2 |
A conjugate is provided for use in directing a moiety to tumors, sites of injury, or sites of blood clots in a subject, wherein the conjugate comprises a moiety linked to a peptide.
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JP2017189178A |
To provide virus-like particles (VLP) containing influenza virus M1 protein, influenza virus H5, N1 hemagglutinin, and neuraminidase protein.The invention discloses and claims virus-like particles (VLP) expressing and/or containing a pro...
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JP2017517281A |
The present invention relates to the formation of emulsions using amphipathic small molecules such as peptides that self-assemble to form an interface between at least two substantially immiscible liquids. Emulsions can be found in a var...
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JP6143269B2 |
The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each oc...
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JP6124150B2 |
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion...
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JP2017506889A |
The present invention relates, in part, to photoactivated ion channel polypeptides and encoding nucleic acids, in part to cells using compositions comprising photoactivated ion channel polypeptides and photoactivated ion channel polypept...
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JP2017048203A |
To provide a method for identifying an immunogen that elicits a cellular and/or humoral immune response when administered as a vaccine.The present invention provides a method comprising the steps of: killing a pathogen culture with an or...
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JP6084359B2 |
The present invention relates to a methods for producing a virus or an immunogenic composition comprising a virus or virus antigen using a culture of cells that have been grown in an animal protein free medium comprising soy hydrolysate ...
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JP6045025B2 |
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JP5951613B2 |
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JP2016104767A |
To provide a pharmaceutical composition for treating disorders characterized by proteinuria, such as diabetic nephropathy, Nephrotic syndromes (i.e. intrinsic renal failure), Nephritic syndromes, Toxic lesions of kidneys, Glomerular dise...
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JP2016063812A |
To provide anti-FcRH5 antibodies useful for treatment of hematopoietic tumors in mammals.An anti-FcRH5 antibody comprises: (a) at least one HVR sequence selected from (i) HVR-L1 comprising the sequence KASQDVSTAVA, (ii) HVR-L2 comprising...
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JP5896547B2 |
The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteri...
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JP5890175B2 |
An object of the present invention is to elucidate a collagen peptide effective for causing dipeptides or tripeptides serving as the active component to enter the blood, and thus to reduce the required intake thereof. According to the pr...
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JP5873005B2 |
DIG-3 Cry toxins, polynucleotides encoding such toxins, and transgenic plants that produce such toxins are useful to control insect pests.
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JP5864425B2 |
Peptides of general formula (I): R1—Wn—Xm-AA1-AA2-AA3-AA4-Yp—Zq—R2 (I) its stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, a preparation process, cosmetic or pharmaceutical composit...
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JP5855651B2 |
The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the prod...
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