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WO/2008/101308A1 |
The present invention relates to a process for producing 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones of formula (1) , including Finasteride and Dutasteride.
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WO/2008/056059A2 |
The present invention pertains to the field of pharmacy, mainly to that of cytoprotection. The invention relates to a family of new chemical compounds, i.e. the 4- azacholest-4-ene N-oxide and certain derivatives thereof, to methods for ...
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WO/2008/000068A1 |
The present invention relates to a new method of preparing 2-iodo triterpenoid and related compounds via the reaction of the corresponding 1 ene-3-ones in the presence of iodine and pyridine in an ether solvent. The method is particularl...
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WO/2007/076656A1 |
A synthesis process of cholest-5-en-3β,19-dihydroxy-24-one and its derivatives includes the steps of: synthesis of 3β-acetoxy-cholest-5-en-24-acid with hyodesoxycholic acid as the starting material; synthesis of 3β-acetoxy-cholest-5-e...
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WO/2007/076655A1 |
A synthesis process of cholest-3β,5α,6β,19-tetrahydroxy-24-one and its derivatives includes the steps of: synthesis of 3β-acetoxy-cholest-5-en-24-acid with hyodesoxycholic acid as the starting material; synthesis of cholenic acid chl...
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WO/2007/064144A1 |
Disclosed herein is a method for preparing sterols by extracting and purifying sterols from deodorizer sludge remaining after removal of tocopherols from soybean oils. The method comprises the steps of saponifying tocopherol-free soybean...
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WO/2007/009201A2 |
The invention refers to a process to obtain synthetic and semi-synthetic derivatives of lignans, especially dibenzylbutyrolactonic, tetrahydrofuranic, aryltetralynic, furofuranic and dibenzocyclooctanic lignans obtained by means of parti...
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WO/2006/077801A1 |
A method for preparing a compound represented by the formula (II): (II), which comprises reacting a compound represented by the formula (I): (I), wherein each of R1 and R1' is independently a lower alkyl optionally having a substituent a...
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WO/2006/045171A2 |
The present invention refers to a process to obtain ergostane derivative dry steroids, such as physalins, including steps of: (a) grinding of dried parts of plant (s) from the Solanaceae species; (b) treatment of the said plant (s)' part...
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WO/2006/013196A1 |
The invention provides a process for the preparation of 2- substituted-derivatives of estrone and estradiol comprising i) the preparation of a compound of general formula (II) by reacting a compound of general formula (I) in one or more ...
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WO/2006/005634A1 |
Crystalline polymorphic Forms A or B of 11β-[4-[5-[(4,4,5,5,5-pentafluoropentyl)suIÂfonyl]pentylox
y] phenyl]-estra-1,3,5(10)-triene-3,17β-diol, their preparation, use and the pharmaceutical compositions comprising Form B.
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WO/2005/121077A1 |
This invention provides a general method for the synthesis of polymer-supported benzoquinones described by the following generic structure I: wherein: •, X, R1, R2 and R3 are described in the main text. The general concept of the metho...
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WO/2005/113577A1 |
The present invention relates to a method for the preparation of trilostane from (4&agr ,5&agr ,17β)-4,5-epoxyandrost-2-eno(2,3-d)isoxazol-17-o1 as a precursor compound, the method comprising the steps of a) dissolving the precursor com...
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WO/2005/095437A1 |
Disclosed is a method for producing a steroid derivative represented by the formula (IV) below which is characterized by reacting a compound represented by the formula (I) below, a compound represented by the formula (II) below and carbo...
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WO/2005/075497A1 |
Process for the preparation of 17ß-substituted-3-oxo-4-aza-5&agr -androstane derivatives, which are useful intermediates for the synthesis of 3-oxo-4-aza-5&agr -androst-1-ene derivatives including finasteride, is provided.
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WO/2005/040190A1 |
A method of extracting oestrogens, conjugated estrogens, equine gonadotropin and equine follicle stimulant from pregnant mares urine which includes the steps of contacting the urine with dispersed particles of adsorber materials of a par...
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WO/2005/021573A1 |
The invention relates to &Dgr 15-D-homosteroids of general formula (I), methods for the production thereof, and pharmaceutical compositions containing said compounds. The inventive compounds of general formula (I) are provided with andro...
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WO/2005/010021A1 |
The invention relates to a method for obtaining an extract which contains the natural mixture of conjugated equine estrogens, whereby the mixture of conjugated estrogens, which is obtained by solid phase extraction from the pregnant mare...
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WO/2005/002496A2 |
The invention relates to a method of obtaining taxosteroids and the precursors thereof from hydrindane bicyclic systems. According to the invention, the compounds have a tetracyclic system which combines the structural characteristics of...
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WO/2004/106358A1 |
The invention relates to dialkyltriazene-supporting estrogens and antiestrogens that are suited for use as chemotherapeutic drugs for treating carcinomas of the sexual organs of humans and animals.
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WO/2004/096829A2 |
The invention relates to a method of preparing compounds having general formula (I), wherein: R1, R2, R3, n and X are as defined in the description. The invention also relates to the intermediate compounds used to implement said method.
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WO/2004/094451A2 |
The invention relates to 8β-vinyl-11β-(&ohgr -substituted)alkyl-estra-1,3,5(10)-trienes of general formula (I), which have ERβ-antagonistic activity, methods for the production thereof, the intermediate products thereof, pharmaceutica...
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WO2004080942B1 |
The invention refers to a process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil (CTO), which is characteriÂsed by the following steps: (a) reacting the free fatty acids present in the CTO with lower ...
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WO/2004/091474A2 |
The invention relates to a method for the production of DHEA derivatives, such as 7-oxo-DHEA and 7-hydroxy-DHEA, from DHEA itself.
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WO/2004/078102A2 |
A process for the sterilization of water insoluble solid medicinal substances is described.The process provides the sterilization of beclomethasone, which is suitable for pulmonary administration. In particular, the process is used in in...
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WO/2004/074233A1 |
The invention refers to a process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil (CTO), which is characterized by the following steps: (b) reacting the free fatty acid present in the CTO with lower alc...
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WO/2004/067546A1 |
The invention relates to novel carboxylic-acid-ester-type tetraalkyl ammonium salts, the production thereof and the pharmaceutical use thereof in fungal and bacterial infections and as potential inhibitors in the biosynthesis of choleste...
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WO/2004/031204A2 |
The present invention is a process for the preparation of l7ß-hydroxy-7&agr -methyl-19-nor-17&agr -pregn-5(10)-en-20-yn-3-one (17&agr -ethynyl-l7ß-hydroxy-7&agr -methyl-5(10)-estren-3-one, tibolone) of formula 1, which comprises hydrol...
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WO/2004/024745A2 |
There is provided a crystalline chemical complex comprising a compound of formula (I) in which the crystal lattice is stabilised by the presence of a guest molecule, characterised in the crystalline complex is of space group P212121 havi...
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WO/2003/095470A1 |
A platinum complex having antitumor activity in which the metal ligands are dehydrocholic acid and a phosphine.
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WO/2003/093292A1 |
The invention relates to compounds of general formula I and the pharmaceutically compatible salts thereof, wherein R1 represents hydrogen, C1- to C6-alkyl, COR4, COOR4, COSR4 or CONHR5, wherein R4 represents C1- to C6-alkyl or unsubstitu...
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WO/2003/090721A2 |
The invention relates to a method for producing crystals from active ingredients in medicaments, the average particle size thereof lying within a given range and the maximum particle size thereof not exceeding a given value. During cryst...
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WO/2003/082896A2 |
The process for the preparation of 6&agr -fluoro steroids, comprising the reaction of the corresponding 6β-fluoro steroids, or of 6&agr /6β isomeric mixtures with an organic base having a diazo iminic group, in a suitably selected orga...
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WO/2003/080643A1 |
A process for producing the compound (V) or a salt thereof, the process being shown by the following reaction scheme. (II) (I) → (III) → (IV) → (V) (In the scheme, R1 and R2 each independently represents C1-8 alkyl.)
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WO/2003/066653A2 |
A process for preparing fluticasone propionate as crystalline polymorphic Form 1 which comprises reacting a compound of formula (II)or a salt thereof with a compound of formula LCH2F wherein L represents leaving group optionally in the p...
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WO/2003/062187A1 |
A process by which 2,5-bis(trifluoromethyl)nitrobenzene can be produced from an industrially easily available material in high yield through a small number of steps under mild reaction conditions using an easily handleable substance with...
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WO/2003/051904A1 |
A process for producing a 21−hydroxypregnane derivative represented by the general formula (III), (III) characterized by protecting the 7−position hydroxy group of a compound represented by the formula (I) (I) and subsequently elimin...
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WO/2003/048183A2 |
The invention relates to a method for obtaining extracts of a natural mixture of conjugated oestrogen from the urine of pregnant mares (PMU). The extracts obtained according to the inventive method fulfil the pharmaceutical specification...
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WO/2003/029267A2 |
The invention relates to the production of 17β-(substituted)-3-oxo-&Dgr 1,2-4-azasteroids (I), wherein R1 is a C1-C4 alkyl, OR2, wherein R2 is a C1-C4 alkyl, or NR3R4, wherein R3 and R4, which may be identical or different, denote hydro...
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WO/2003/021739A2 |
A serial battery charger including a number of serially connected battery charging section(410,420,430,440)in which the battery charging section is characterized by a first and second parallel connected branches. The first branch include...
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WO/2003/020860A2 |
This invention relates to methods for treating distillates obtained during the process of deodorizing various oils. More particularly, this invention relates to methods for recovering fatty acids, tocopherols, and sterols from a distilla...
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WO/2003/010181A1 |
The invention relates to 6$g(a)-fluoropregnanes (I), wherein: the line of points between positions 1 and 2 represents a single or double bond; R¿1? denotes OH, OCOR¿2?, X, SO¿3?R¿3? or a (R¿7?)(R¿8?)(R¿9?)SiO-group, wherein X is h...
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WO/2002/100880A1 |
The invention concerns a method for preparing compounds of formula (I) wherein: R¿1?, R¿2?, R¿3? and n are such as defined in the description, the use of said compounds as intermediates for preparing oestrogen derivatives and the inte...
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WO/2002/100878A1 |
A process for preparing flumethasone (6a,9a-diffluoro-11$g(b),17a,21-trihydroxy-16a-methyl-pregna
-1,4-diene-3,20-dione), fulmethasone 21-acetate or its 17-carboxyl androsten analogue which process comprises reacting a compound of formul...
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WO2001042272A9 |
A novel crystalline form (Form H) of the aldosterone receptor antagonist drug eplerenone is provided having a relatively rapid dissolution rate in aqueous media. Also provided are novel solvated crystalline forms of eplerenone that, when...
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WO/2002/088166A1 |
Certain bile acids find use in the pharmaceutical industry. In view of the wide distri-bution of serious diseases such as HIV, AIDS and Bovine Spongiform Encephalopathy (BSE) it is desirable to avoid - as far as practicable - to have any...
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WO/2002/079221A2 |
The invention discloses certain steroidal sapogenins and derivatives thereof, and their use in the treatment of cognitive dysfunction, non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, and receptor loss in the ab...
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WO/2002/046207A2 |
An improved process for preparing steroids, such as 3-oxo-4-azasteroids, is described. Compounds of this type are known to be useful in the preparation of compounds having 5a-reductase inhibitor activity. The process comprises the hydrog...
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WO/2002/032922A1 |
A process for preparing an intermediate compound of formula (II): where X is as defined in the specification, R1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R?2¿, R?3¿, R?4¿ and R?5Â...
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WO/2002/027013A1 |
It is intended to provide synthetic reaction conditions for producing edible sterol fatty acid esters having physiological activities from plant-origin sterols and fatty acids or fats and oils by using lipase as a catalyst, and edible st...
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