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JPH10147593A |
To simply produce the subject compound useful as a synthetic intermediate, etc., for medicines by reacting a specific 3-hydroxysteroid derivative with phthalimide and then reacting the resultant compound with hydrazine hydrate or phenylh...
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JP2753562B2 |
PURPOSE: To obtain the subject derivative useful in treatment, etc., of benign or malign diseases of genitals, etc., which is a novel 11-benzaldoxime-estra-diene derivative and has a good progesterone inhibitory effect and an anti- gluco...
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JP2752366B2 |
1. Process for the manufacture of 17 alpha-ethynyl-17 beta-hydroxy-18-methyl-4,15-estradien- 3-one of the formula I see diagramm : EP0285548,P6,F1 characterised in that a 17-enol ester of the general formula II see diagramm : EP0285548,P...
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JP2744062B2 |
PURPOSE:To obtain the title compound useful as a cholagogue in high purity and high yield by subjecting 3-hydroxy-7-ketocholanic acid or 3-hydroxy-7- keto-11-choleic acid in the presence of a base using a palladium based catalyst. CONSTI...
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JP2742409B2 |
Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17β-carboalkoxy-4-aza-5α-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the este...
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JPH10101694A |
To obtain a novel subject compound which comprises a steroidal compound of a specific structure and is useful as a synthetic intermediate for activated type vitamin D derivative having excellent bode mass improvement, differentiation ind...
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JP2736169B2 |
Polymorph "A" a novel polymorphic form of N-t-butyl-androst-3,5-diene-17 beta -carboxamide-3-carboxylic acid. Novel processes for preparing polymorph "A" are also disclosed.
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JP2721002B2 |
The invention relates to a new process for the preparation of known aromatase inhibitors of the following formula (I) wherein each of R1 and R3, independently, is hydrogen or C1-C6 alkyl; R2 is hydrogen, halogen or C1-C6 alkyl; and R4 is...
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JP2720933B2 |
This disclosure describes disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 Complex.
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JP2718834B2 |
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JPH10500682A |
The instant invention involves a process for oxidizing compounds containing an allylic group, i.e. those containing an allylic hydrogen or allylic alcohol group, to the corresponding enones, using a ruthenium-based catalyst in the presen...
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JP2696672B2 |
11-Benzaldoxime-oestradiene derivatives of the general formula I and their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them are described. The described compounds display ...
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JP2694282B2 |
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JP2680231B2 |
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JP2673930B2 |
PURPOSE: To produce sterol glycoside and a long-chain dibasic acid simply and easily at a low cost by separating the sediment of a crude sesame oil using a polar or alkali-contg. polar solvent. CONSTITUTION: The sediment of a crude sesam...
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JP2648450B2 |
PURPOSE: To recover tocopherols and sterols from natural, especially vegetable, sources. CONSTITUTION: This is the separation method of tocopherols and sterols from deodorizer sludges by distillation of these deodorizer sludges, in that ...
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JPH09221496A |
To obtain a new steroidal compound exhibiting strong cell toxicity to a cancerized cell and useful as a medicine, etc., such as a carcinostatic agent or an antitumor agent by separating and purifying an extract obtained by extracting Cle...
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JP2621976B2 |
These complexes have a melting point 10 to 25 DEG C lower than that of the constituent of the complex melting at the lower temperature, and contain a molar proportion of anthralin of between 10 and 90%. These complexes are intended for t...
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JP2610674B2 |
PCT No. PCT/US88/02429 Sec. 371 Date Jan. 30, 1990 Sec. 102(e) Date Jan. 30, 1990 PCT Filed Jul. 22, 1988 PCT Pub. No. WO89/01483 PCT Pub. Date Feb. 23, 1989.The invention involves a two step chemical transformation of a steroidal 17-cya...
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JP2608322B2 |
(22E)-5,7,22-Ergostatriene-1 alpha ,3 beta ,25-triol and the 24-epimer thereof which are new intermediates for the synthesis of 1 alpha ,25-dihydroxyvitamin D2 and the 24-epimer thereof. A new process for the preparation of 1 alpha ,25-d...
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JPH09118687A |
PURPOSE: To profitably and easily obtain a pharmaceutically useful steroid by a method using a new production intermediate. CONSTITUTION: This method for producing a 17α-hydroxy-20-oxopregnane derivative comprises converting a steroid d...
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JP2604842B2 |
The present invention involves improved processes for the dehalogenation of 9 alpha -halosteroids (I) (I) to produce the corresponding 11 beta -hydroxy steroids (II) (II) which are known to be useful as pharmaceutical, where the improvem...
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JP2599255B2 |
PURPOSE: To provide a process to prepare a 15-oxygenated sterol, e.g. 3β- hydroxy-5α-cholest-8(14)-en-15-one. CONSTITUTION: This process comprises the steps of: converting 7- dehydrocholesterol to 3β-benzoyloxycholesta-5,7-diene, conv...
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JP2584829B2 |
9(11)-dehydroandrostanes and 9(11)-dehydropregnanes are prepared by dehydrating the corresponding 9-alpha-hydroxy steroid in the presence of a Lewis acid. The corresponding 8(9)-dehydro-isomer was not detectable. The resulting products a...
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JP2578399B2 |
PCT No. PCT/US93/01709 Sec. 371 Date Dec. 20, 1994 Sec. 102(e) Date Dec. 20, 1994 PCT Filed Mar. 2, 1993 PCT Pub. No. WO94/00478 PCT Pub. Date Jan. 6, 1994A process for the synthesis of peracyl-1-O-steroidal- beta -cellobiosides that pro...
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JPH0912593A |
To obtain the new derivatives comprising a specific 17- hydroxyiminoalkylcyclopentane perhydrophenanthrene derivative, etc., having affinity to Na+, K+-ATPase receptors, and useful for the therapy of cardiac failures, hypertension, etc. ...
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JPH08319295A |
PURPOSE: To obtain a nucleic acid compound having an orientation fixed by a cyclic skeleton, comprising a non-nucleic acid cyclic skeleton containing two functional groups in the same direction and two nucleic acid chains bonded to the s...
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JP2552507B2 |
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JP2554006B2 |
PURPOSE: To surely acylate phenolic hydroxyl group at the 3-position of estradiol. CONSTITUTION: This method for selectively acylating estradiol is characterized by selectively introducing an N-bis(2-chloroethyl)carbamoyl halogenide into...
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JP2549721B2 |
17 beta -Cyano-17 alpha -hydroxy steroids (I) are transformed to 17 alpha -halo silyl ethers (II) which are intermediates useful in the production of progesterones (V), 17-hydroxyprogesterones (VI), corticoids (VII) and 21-halo corticoid...
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JP2530789B2 |
The present invention relates to ceramic materials containing a homogeneous dispersion of metal particles, particularly sol-gel ceramic materials, a method of preparing the same, and processes for hydrogenating and oxidizing organic comp...
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JP2515967B2 |
PURPOSE: To obtain a new process for the preparation of corticoid and progesterone useful as pharmaceuticals by reacting a specific α-halo silyl ether with a non-nucleophilic base and then, reacting the resulting product with two specif...
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JPH08176187A |
PURPOSE: To newly obtain 14α-hydroxy-4-androstene-3,6,17-trione useful as an anti-cancer medicine. CONSTITUTION: 14α-Hydroxy-4-androstene-3,6,17-trione is obtained by oxidizing a hydroxyl group at 6-position of 6,14α-dihydroxy-4-andro...
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JP2512388B2 |
PURPOSE: To obtain the subject compound having a specific formula, useful as an intermediate for preparing an aza-steroid or a radioactively labeled GABA-receptor substance. CONSTITUTION: This intermediate is expressed by formula I (A is...
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JP2512389B2 |
PURPOSE: To obtain the subject compound having a specific formula, useful as an intermediate for preparing an aza-steroid or a radioactively labelled GABA-receptor substance. CONSTITUTION: This intermediate is expressed by formula I (A i...
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JP2512390B2 |
PURPOSE: To obtain the subject compound having a specific formula, useful as an intermediate for preparing an aza-steroid or a radioactively labelled GABAreceptor substance. CONSTITUTION: This intermediate is expressed by formula I (A is...
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JP2509467B2 |
PURPOSE: To obtain a novel compound good in crystallinity, useful as a starting material for producing strong active gestagen used for contraceptive regulators and capable of producing gestoden by one shot method in good yield. CONSTITUT...
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JPH08134095A |
PURPOSE: To obtain a novel steroid which is useful for a cosmetic and an anticancer agent because of its keratinization enzyme promotion action and anticancer action by reaction of 20-formyl-6-oxo-2,3,14,20-tetrahydroxypregn-7-ene with a...
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JPH08504825A |
The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R<1> and R<2> i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R<1> ...
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JPH08113592A |
PURPOSE: To easily produce and separate the subject compound useful as an intermediate for synthesizing activated vitamin D3 in an industrially advantageous way. CONSTITUTION: Typically, a mixture comprising a steroid having double bond ...
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JPH08503473A |
Invented are novel 17 alpha -acyl steroidal 5 alpha -reductase inhibiting compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5- alpha -reductase. Also invented are ...
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JPH08503471A |
Invented are 17 alpha and 17 beta -substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5- alpha...
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JPH0881492A |
To profitably obtain the subject derivative useful as an intermediate for synthesizing steroid compounds and so on through several kinds of intermediates comprising new compounds by allowing a 17-keto-steroid derivative to react with a h...
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JPH0826064B2 |
Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypocholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting alpha -cellobiosyl bromide heptaalka...
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JPH0834794A |
PURPOSE: To obtain a new sterol compound having excellent antineoplastic activity, useful as a medicine, etc., by chemical modification of aragusterols extracted and isolated from a sponge belonging to Xestospongia. CONSTITUTION: This ne...
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JPH085910B2 |
Process for the production of a DELTA <17(20)>-steroid of formula (II) which comprises starting with a 16-unsaturated corticoid of formula (I) and contacting the 16-unsaturated corticoid (I) with a methylating agent in the presence of a ...
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JPH07116220B2 |
A process for preparing ketocholanate(s) comprises oxidizing cholanic acid compound(s), such as alkyl 3 alpha -alkoxycarbonyloxy-7 alpha ,12 alpha - dihydroxycholanates or alkyl 3 alpha -acyloxy-7 alpha ,12 alpha -dihydroxycholanates, wi...
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JPH07116221B2 |
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JPH07116219B2 |
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JPH07116217B2 |
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