Steroids

Matches 251 - 300 out of 1,158	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2008/034796A2	ESTRATRIENE DERIVATIVES AND THEIR USES AS 17BETA-HYDR0XYSTER0ID DEHYDROGENASE INHIBITORS This invention relates to novel estratrien-triazoles of general formula (I) useful in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease ...
WO/2007/140380A2	TAGGING REAGENTS AND METHODS FOR HYDROXYLATED COMPOUNDS In various aspects, the present teachings provide labeling reagents and sets of labeling reagents containing one or more heavy atom isotopes for the relative quantitation, absolute quantitation, or both, of hydroxylated compounds includi...
WO/2007/118830A1	AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are ...
WO/2007/118832A2	AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are ...
WO/2007/081835A2	MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES The invention features compounds of formulas I or II: and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.
WO/2007/073424A1	PURE ROCURONIUM BROMIDE The invention encompasses substantially pure rocuronium bromide.
WO/2007/033348A2	PROCESS FOR THE SYNTHESIS OF ROCURONIUM BROMIDE The invention encompasses processes for synthesizing l-[17β-acetyloxy-3α- hydroxy-2β-(4-morpholmyl)-5α-androstan-16β-yl]-l-(2-prope nyl)pyrrolidinium bromide (rocuronium bromide) and intermediates thereof.
WO/2007/031833A2	NOVEL SERIES OF IMIDAZOLYL SUBSTITUTED STEROIDAL AND INDAN-1-ONE DERIVATIVES The present invention provides a novel series of imidazolyl substituted steroidal and indan-1-one derivatives and salts thereof having the following general structural formulae (A and B)
WO/2007/025632A2	NITROOXY DERIVATIVES OP GLUCOCORTICOIDS The invention relates to new steroids nitrooxyderivatives, to topical pharmaceutical formulations thereof, and their use for treating skin or mucosal membrane diseases or disorders. These new steroids nitrooxyderivatives have an improved...
WO/2007/024338A2	3 -ESTER PRODRUGS OF ETHYNYLESTRADIOL The present invention is a prodrug derivative of ethinyl estradiol according to Formula I: Formula I
WO/2007/008474A2	3 -ESTER PRODRUGS OF ESTRADIOL The present invention is a prodrug derivative of estradiol according to Formula I:
WO/2006/125800A1	17β-HSD1 AND STS INHIBITORS The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may represent inhibitors of the steroid sulpha...
WO/2006/093993A1	NOVEL C-17-HETEROARYL STEROIDAL CYP17 INHIBITORS/ANTIANDROGENS: SYNTHESIS, IN VITRO BIOLOGICAL ACTIVITIES, PHARMACOKINETICS AND ANTITUMOR ACTIVITY Described are steroidal C- 17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic 'addition-elimination' substitution re...
WO/2006/055009A1	BILE ALCOHOLS AS ATTRACTANTS FOR MIGRATORY LAMPREY Compounds that function as lamprey attractants and methods.
WO/2006/046123A2	CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure VIII: L represents the chain of the substructure IX or XIII: Z represents the steroid or nonsteroidal s...
WO/2006/038047A1	ENVIRONMENT-FRIEND PROCESS FOR THE SYNTHESIS OF QUATERNARY AMMONIO-STEROΙDS The invention relates to a new, environment-friend process for the synthesis of the known 4,4'-[3α,17β-bis(acetoxy)-5α-androstane-2β,l6β-diyl]-bi s(l,l-dimethyl-ρiρerazinium) dibromide of formula (I) (from now on pipecuronium brom...
WO/2006/032885A2	2-SUBSTITUTED ESTROGEN SULPHAMATES FOR INHIBITION OF STEROID SULPHATASE The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of -OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide gr...
WO/2006/021776A1	METHANESULFONATE SALTS OF ABIRATERONE-3-ESTERS AND RECOVERY OF SALTS OF ABIRATER ONE-3-ESTERS FROM SOLUTION IN METHYL TERT-BUTYL ETHER A salt of a compound of formula (I) may be made with methanesulfonic acid. The salt and salts with other acids may be prepared by recovering from methyl tert-butyl ether (MTBE).
WO/2006/021777A1	PROCESS FOT THE PREPARATION OF 17-0-VINYL- TRIFLATES AS INTERMEDIATES A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of formula (III) in the presence of a base compr...
WO/2005/118612A1	CHOLESTEROL/BILE ACID/BILE ACID DERIVATIVE-MODIFIED THERAPEUTIC ANTI-CANCER DRUGS Cholesterol-modified anti-cancer therapeutic drug compounds, bile-acid-modified anti-cancer therapeutic drug compounds, and bile-acid-derivative-modified anti-cancer therapeutic drug compounds; emulsion, microemulsion, and micelle formul...
WO/2005/105822A2	3-ALPHA-HYDROXY 21-N- HETEROARYL-PREGNANE DERIVATIVES FOR MODULATION OF BRAIN EXCITABILITY AND A PROCESS FOR THE PRODUCTION THEREOF The invention relates to a novel multi step process of making compounds of Formula (I), wherein R1 is an alkoxy group and R2 is an optionally substituted, N-attached heteroaryl. The hydrogen at the 5-position can be &agr or β isomer, pr...
WO/2005/092912A1	PROGESTERONE RECEPTOR MODULATORS The subject invention provides a compound according to Formula I, wherein Formula (1) is O, NOH, NO(1-4C)alkyl, NO(1-4C)acyl; Al-A5 are C, substituted with RI, or N, provided that at least one and not more than three of Al-A5 are N; or o...
WO/2005/068487A2	PROCESSES FOR THE PREPARATION OF ROCURONIUM BROMIDE AND INTERMEDIATES THEREOF A novel process for preparing (2beta,3alpha,5alpha,16alpha,17beta)-17-acetoxy-3-hydroxy-2- (4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is discl...
WO/2005/014613A1	THIOMORPHOLINO STEROID COMPOUNDS, THE USE THEREOF FOR THE PREPARATION OF MEIOSIS-REGULATING MEDICAMENTS AND METHOD FOR THE PREPARATION THEREOF The present invention relates to thiomorpholino steroid compounds of general formula (I), which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by a thiomorpholino moiety...
WO/2005/007670A1	METHOD FOR THE PREPARATION OF HIGHLY PURE 1-ANDROSTENE DERIVATIVES A method for preparing a 1-androstene derivative which comprises reacting a 2-iodo-androstane derivative with an oxidizing agent while maintaining the pH of the reaction mixture at a specific range gives the 1-androstene derivative with ...
WO/2004/101595A1	ESTRATRIENE DERIVATIVES Compounds and methods for modulating mesenchymal cell function, for instance smooth muscle and fibroblast proliferation or cytokine expression, and for treating conditions associated with mesenchymal cell function, for instance airway hy...
WO/2004/098538A2	NITROSATED AND NITROSYLATED COMPOUNDS, COMPOSITIONS AND METHODS OF USE The invention describes novel nitrosated and/or nitrosylated compounds of the invention, and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated compound of the inventi...
WO/2004/096829A2	NOVEL METHOD AND INTERMEDIATES FOR THE PREPARATION OF 19-NOR-STEROIDS-17-HALOGEN COMPOUNDS The invention relates to a method of preparing compounds having general formula (I), wherein: R1, R2, R3, n and X are as defined in the description. The invention also relates to the intermediate compounds used to implement said method.
WO/2004/096830A1	SYNTHESIS OF SOLANUM GLYCOSIDES The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (II), where each R1 is the same or diffe...
WO/2004/085459A1	OESTROGEN DERIVATIVES AS INHIBITORS OF STEROID SULPHATASE The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of -OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide gr...
WO/2004/066920A2	17-CARBAMOYLOXY CORTISOL DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS The present invention encompasses compounds of Formula (I) or ph armaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory dis...
WO/2004/045536A2	METHOD AND COMPOSITIONS FOR TEMPORARILY INCAPACITING SUBJETS A method for modifying at least one non-ester-containing parent compound, and the compounds produced using such method, which compounds are deployed to temporarily incapacitate at least one subject are disclosed. The modified compounds a...
WO/2004/045533A2	METHOD AND COMPOSITIONS FOR TREATING PERSISTENT PULMONARY HYPERTENSION USING ARALKYL ESTER SOFT DRUGS A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious par...
WO/2004/043986A1	PROCESSES FOR PREPARING C-7 SUBSTITUTED 5-ANDROSTENES This invention relates to processes for the preparation of novel , substituted steroid compounds of Formula 1, wherein R1 is H or. COR2; R2 is C1-C6 alkyl or Ct-C6 alkoxy; Z1 is CH2, or wherein OR3 is in the &agr configuration; R3 is H o...
WO/2004/037843A2	STEROID COMPOUNDS COMPRISING SUPEROXIDE DISMUTASE MIMIC GROUPS AND NITRIC OXIDE DONOR GROUPS, AND THEIR USE IN THE PREPARATION OF MEDICAMENTS The present invention relates to multifunctional steroid compounds combining a steroid component with SOD mimic component and optionally also with NO donor component, and to their use in treating and preventing disorders associated with ...
WO/2004/005310A2	NEW COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES AND CONDITIONS The present invention relates (a) to new compounds represented by Formula (I): wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, S represents...
WO/2004/005313A2	HYBRID MOLECULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES The present invention relates (a) to new compounds represented by Formula I wherein M represents a macrocode subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, V represents an...
WO/2004/000802A2	SCAFFOLDED MALEIMIDE CLUSTERS FOR MULTIVALENT PEPTIDE ASSEMBLY Disclosed are scaffolded maleimide clusters, methods of making said clusters and use of said clusters as templates for multivalent peptide assembly. Multiple maleimide functionalities were introduced onto a scaffold molecule by the react...
WO/2003/089449A2	AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY The invention relates to sterol derivatives of formula (I) and to a method for the production of said compounds, a medicament using one of said compounds and a pharmaceutical composition comprising said medicament.
WO/2003/072555A1	SUBSTITUTED 3-PHENYL-5-ALKOXY-1,3,4-OXADIAZOL-2-ONES, THE PRODUCTION THEREOF AND THEIR USE IN MEDICAMENTS The invention relates to substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, of general formula (I), wherein R1 represents C7-C22 alkyl, C2-C4 alkyl that is substituted by C4-C20 alkoxy, C6-C10 aryl, C6-C10 aryloxy or C4-C12-alkoxy-C2-...
WO/2003/070194A2	AMINO ACID AND PEPTIDE-MODIFIED FORMS OF GLUCOCORTICOIDS Amino acid corticosteroid esters which may function as pro-drugs, and formulations of the amino acid corticosteroid esters with a second active ingredient such as formoterol are disclosed. Composition of the invention include amino acid ...
WO/2003/064443A2	NEW CORTICOSTEROIDS Nitrooxy derivatives of steroidal compounds of general formula (I) B− X1 − NO2 or esters or salts thereof, wherein: B is a steroidal radical, X1 is a bivalent linking group comprising an aromatic or heterocyclic ring.
WO/2003/053360A2	TREATMENT OF EBV AND KHSV INFECTION AND ASSOCIATED ABNORMAL CELLULAR PROLIFERATION A method and composition for the treatment, prevention and&sol or prophylaxis of a host, and in particular, a human, infected with Epstein−Barr virus (EBV), is provided that includes administering an effective amount of a 5−substitut...
WO/2003/045972A1	17$g(a)-ALKYL-17$g(b)-OXY-ESTRATRIENES AND INTERMEDIATES FOR THE PRODUCTION THEREOF, AND USE OF SAID 17$g(a)-ALKYL-17$g(b)-OXY-ESTRATRIENES FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS The invention relates to 17$g(a)-alkyl-17$g(b)-oxy-estra-1,3,5(10)-trienes having an anti-oestrogen action, of general formula (I). The invention also relates to 17-oxo-estra-1,3,5(10)-trienes and 17$g(b)-hydroxy-estra-1,3,5(10)-trienes ...
WO/2003/035668A2	NOVEL ANTI-INFLAMMATORY ANDROSTANE DERIVATIVES -17-CARBOXY-LACTONE SUBSTITUTED STEROIDS WITH AN ARYL-CARBOXYLIC ESTER IN POSITION 17.ALPHA Novel Anti-inflammatory Androstane DerivativesThere are provided compounds of formula (I) wherein R1 represents O, S or NH;R2 represents -C(&equals O)-aryl or -C(&equals O)-heteroaryl;R3 represents hydrogen, methyl (which may be in eithe...
WO/2003/026568A2	ANDROSTANES AS ANDROGEN RECEPTOR MODULATORS Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating a function of the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of ...
WO/2003/024940A1	BIFUNCTIONAL CHELATING AGENT FOR ACTINIUM The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents −X or −phenyl−X, wherein X represents NO2, NH2, NCS, NHCOCH2−Z, NHCO−W−COCNHS, −NH−Q, −NHCS−Q, −NHCOC...
WO/2003/009853A1	METHODS FOR PREVENTING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents capable of inhibiting the binding of cortisol to its receptors can be used in methods for preventing antips...
WO/2002/100879A1	NOVEL ANTI-INFLAMMATORY 17.ALPHA.-HETEROCYCLIC-ESTERS OF 17.BETA.CARBOTHIOATE ANDROSTANE DERIVATIVES There are provided compounds of formula (I) wherein R¿1? represents C¿1-6? alkyl or C¿1-6? haloalkyl; R¿2? represents a 4-7 membered non-aromatic ring containing 1-3 heteroatoms selected from O, N and S optionally substituted with on...
WO2001042273A9	ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and allevi...

Matches 251 - 300 out of 1,158	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >