Steroids

Matches 551 - 600 out of 1,158	< 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >

Document	Document Title
JP2021147322A	STEROIDAL COMPOUND AND MEDICINAL USE THEREOF To provide a TSLP production inducer or an agent for autoimmune disease.As concrete compounds, illustrated are a steroidal compound represented by the following formula HA-7 or a salt thereof.SELECTED DRAWING: None
JP6924765B2	Steroid derivative FXR agonist The present invention relates to a compound represented by formula (I), a tautomer thereof or a pharmaceutically acceptable salt thereof, and relates to applications thereof in the preparation of drugs for treating FXR related diseases.
JP6909155B2	Compositions and Methods for Treating CNS Disorders The present invention relates to the compound of the formula given below or a pharmaceutically acceptable salt thereof. This compound is envisioned, in certain embodiments, to behave as a GABA modulator. The present invention also provid...
JP6906525B2	Inhibitor of glucocorticoid receptor The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The s...
JP6893173B2	Compositions and Methods for Treating CNS Disorders Described herein are neuroactive steroids of the Formula (II):or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6and------are as defined herein. Such compounds are envisioned, in certain emb...
JP6892071B2	New thioflavin T derivative and its use To provide an N3-thioflavin T derivative that specifically binds to a target molecule to emit fluorescence.The present invention provides an N3-thioflavin compound represented by formula (I) or a salt thereof: a detection agent for a tar...
JP6875996B2	Neurostimulatory steroids, compositions, and their use Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof; wherein R1, R2, Ra, G, X, Y, Z, and n are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as ...
JP2021512909A	Steroidal derivative modulator, its manufacturing method and application The present invention relates to a steroidal derivative modulator, a method for producing the same, and an application thereof. The present invention particularly relates to a compound represented by the general formula (I), a method for...
JP2021073250A	AMINOSTEROID COMPOUNDS FOR TREATMENT OF PTP1B ASSOCIATED DISEASE To provide aminosteroid compounds for selective inhibition of the enzyme PTP1B in a mammal, and compositions comprising the aminosteroid compounds.The invention provides various aminosteroid compounds which inhibit protein phosphatase IB...
JP6867577B2	Panaxidiol-type ginsenoside derivative, its production method and its use Provided are panaxdiol-type ginsenoside derivatives having structures as shown in formula I or formula II. Also provided are the uses thereof in the preparation of drugs for preventing and treating atherosclerosis. The panaxdiol-type gin...
JP6861703B2	TGR5 modifiers and how to use them The application relates to compounds of formula (A): or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, includin...
JP6857124B2	Bile acid derivatives as FXR / TGR5 agonists and how to use them The present invention provides compounds of Formula I,pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
JP6853833B2	Combination of estrogen receptor regulators Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
JP6842474B2	Steroid compounds, compositions containing the compounds and their use Provided in the present invention are a steroidal compound, a composition containing the same and a use thereof. Specifically, disclosed in the present invention are a steroidal compound as shown in formula (I) and a drug composition con...
JP2021505608A	Juuterized 21- [4-cyano-pyrazole-1-yl] -19-nor-pregan-3.α-ol-20-one derivative for treating CNS disorders Equation (I)(In the formula, R3a, R5, R6a, R6b, R17, R21a, R21b, Rm, Rn, R16a, R16b, R7a, R7b, R12a, R12b, R11a, R11b, R2a, R2b, R19, R4a, And R4bProvided herein is a deuterized compound (as defined herein) or a pharmaceutically acceptab...
JP2021504480A	Compounds for treating myopia Cataracts and presbyopia affect billions of people worldwide. Described herein are new compounds and methods for treating and preventing these diseases. The present disclosure provides new compounds, salts, compositions and their use in ...
JP6802862B2	Inhibition of hepatitis B virus and hepatitis D virus and NTCP transport by polymerized bile acid derivatives The invention provides for treating HBV or HDV infection or inhibiting human sodium taurocholate co-transporting polypeptide (hNTCP) with a polymeric bile acid or salt thereof, and pharmaceutical compositions comprising a polymeric bile ...
JP2020536566A	Bile acid hydrolase probe and its manufacturing method and usage method Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity, as well as devices and kits that use the probes, are described herein. It also describes how to make and use probes, devices, and kits. In some ...
JP6800748B2	Lipid-based platinum compounds and nanoparticles The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corres...
JP2020189848A	COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS To provide compositions and methods for treating CNS disorders.Described herein are neuroactive steroids represented by the general formula (I) in the figure or a salt thereof. The compounds are supposed, in certain embodiments, to act a...
JP6785788B2	Bile acid derivatives as FXR / TGR5 agonists and how to use them The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof,The invention also provides pharmaceutical compositions comprising these co...
JP6784735B2	19-Nor C3,3-di-substituted C21-N-pyrazolyl steroid and how to use it According to the present application, there is provided the compound of the formula indicated herein or a pharmaceutically acceptable salt thereof in the treatment in humans of bipolar disorder, anxiety disorder, depression, tremor or ti...
JP2020180161A	19-NOR NEUROACTIVE STEROIDS AND USE METHODS THEREOF To provide 19-nor neuroactive steroids and use methods thereof.The invention is based, in part, on the desire to provide novel 19-nor (i.e., C19 desmethyl) compounds, e.g., related to progesterone, deoxycorticosterone, and their metaboli...
JP6745274B2	Compositions and Methods for Treating CNS Disorders Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof; wherein , A, R1, R2, and R3 are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modul...
JP6742308B2	Compositions and Methods for Treating CNS Disorders Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof; wherein - - - - - -, R1, R2a, R2b, R3and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behav...
JP6703484B2	Quinone-masked probe as a labeling reagent for cell uptake measurements Provided are labeling reagents and methods of using the reagents for cell uptake measurements. The labeling reagents can be quinone-masked probes including fluorophores and/or luminophores.
JP6704535B2	Lanosterol prodrug compound, its production method and application Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treat...
JP6690349B2	Luminescent organic thin film, organic electroluminescence element, display device and lighting device To provide a long-life organic EL element which exhibits less deterioration in luminous efficiency due to oxygen and water and achieves high luminous efficiency.A luminescent organic thin film contains a steroid skeleton compound represe...
JP2020063314A	COMPOUNDS AND METHODS FOR ENHANCED DEGRADATION OF TARGETED PROTEINS AND OTHER POLYPEPTIDES BY E3 UBIQUITIN LIGASE To provide bifunctional compounds, which find utility as modulators of targeted ubiquitination and as inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited.Compounds contain on one end a ...
JP6664408B2	A compound that is an analog of squalamine used as an antibacterial agent The invention relates to compounds of formula (I), to the pharmaceutical compositions comprising same, and to the use thereof in the treatment of bacterial, fungal, viral and parasitic infections or in the treatment of cancer in humans o...
JP6652934B2	Neurostimulatory steroids, compositions, and their use Described herein is a compound of the formula:for use in a method for treating essential tremor in a subject in need thereof comprising administering to the subject the compound. The present invention also provides a pharmaceutically acc...
JP6650509B2	Actinic light-sensitive or radiation-sensitive resin composition, resist film, pattern forming method, manufacturing method of electronic device The present invention provides: an active light sensitive or radiation sensitive resin composition which is capable of forming a pattern that has low LWR and is suppressed in collapsing; a resist film; a pattern forming method; and a met...
JP6621217B2	Compounds and their use to improve muscle quality Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using ...
JP2019210297A	FARNESOID X RECEPTOR MODULATORS To provide farnesoid X receptor modulators.The present application provides a compound of a formula I in the figure or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof, as described herein. The present inventio...
JP2019210236A	METHODS OF MAKING TOMATIDINE OR ESCULEOGENIN AND PRODUCTS USING TOMATIDINE OR ESCULEOGENIN To provide methods of making tomatidine or esculeogenin by a simple industrial technique, and products exploiting the properties of the obtained tomatidine or esculeogenin.Disclosed herein is a method for producing tomatidine comprising ...
JP6608929B2	Estrogen receptor regulator Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
JP2019532079A	Oxysterols and how to use them Equation (A):Compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions thereof are provided in the formula, R.1, R2, R3, R4, R5, R6And RGIs as defined herein. The compounds of the present invention are inten...
JP2019524853A	Crystalline 19-nor C3,3-disubstituted C21-N-pyrazolyl steroid The present invention has the formula (I).19-Nor C3,3-disubstituted C21-pyrazolyl steroids and their crystalline solid forms and compositions. A method for producing a crystalline solid form of a 19-nor C3,3-disubstituted C21-pyrazolyl s...
JP2019142892A	BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE To provide therapeutic compositions and methods for treating or ameliorating hypercholemia and/or cholestatic liver disease.A composition for use in treatment of hypercholemia comprises an apical sodium-dependent bile acid transporter in...
JP6556125B2	A therapeutically active 17-nitrogen-substituted estratrientiazole derivative as an inhibitor of 17β-hydroxysteroid dehydrogenase The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2 to R7 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD and in treatment or preve...
JP6545266B2	17β-HSD1 inhibitor prodrug The present invention accordingly provides novel compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the claims. The invention further relates to their in treatment or prevention of steroid hormone dependent diseases or ...
JP2019094260A	NANOPARTICULATE FORMULATIONS FOR CANCER DISEASE TREATMENT To provide drugs for use in treatment of cancer disease, in particular, a compound comprising an aqueous and hardly absorbable drug 10-hydroxy 7-ethylcamptothecin (SN-38) to which a lipid-soluble organic acid is bound, as well as nanopar...
JP6523461B2	17β-HSD1-Inhibitor prodrug The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R1 to R4 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD1 and in treatment or prev...
JP2019059781A	AMINO STEROID COMPOUND FOR TREATMENT OF PTP1B ASSOCIATED DISEASE To provide amino steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal, and compositions containing these amino steroid compounds.This application is directed to various amino steroid compounds for the inhibition...
JP2019048851A	MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES To provide modified drugs for use in liposomal nanoparticles.Provided herein is a drug derivative suitable for loading into liposomal nanoparticle (LN) carriers. In some preferred aspects, the derivative comprises a drug with low water s...
JP2019505489A	Phospholipidization of imidazole quinoline and oxoadenine The present invention relates to a method for phospholipidizing imidazoquinoline and oxoadenine. More specifically, the present invention relates to high yield and expandable means of phospholipidation of imidazole quinoline and oxoadeni...
JP6474799B2	Method for preparing avilateron and its intermediates The present invention provides intermediates for preparing abiraterone, and processes for preparing abiraterone and intermediates thereof. The intermediates include a compound of formula (IV): wherein R represents a hydroxy-protecting gr...
JP6470258B2	19-Nor C3,3-di-substituted C21-N-pyrazolyl steroid and how to use it According to the present application, there is provided the compound of the formula indicated herein or a pharmaceutically acceptable salt thereof in the treatment in humans of bipolar disorder, anxiety disorder, depression, tremor or ti...
JP6466942B2	Neuroactive steroids, compositions, and their use Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof; wherein ------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GA...
JP6461127B2	17β-Hydroxysteroid dehydrogenase, therapeutically active estratrientiazole derivative as a type I inhibitor The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R1 to R6 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD and in treatment or preve...

Matches 551 - 600 out of 1,158	< 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >