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JPS5555200A |
The steroids of the present invention have been found to be useful as male contraceptives when administered orally. Upon cessation of administration of the male contraceptive steroids of the present invention the male promptly regains no...
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JPS5520789A |
11 beta ,21-Dihydroxypregna-1,4,17(20)-triene-3-one 21-acetate (0) is epoxidized, followed by ring opening and hydrolysis to give 11 beta ,20,21-trihydroxypregna-1,4,16-triene-3-one 21-acetate (III), an intermediate in the synthesis of b...
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JPS5443511B2 |
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JPS5442971B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
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JPS5442973B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
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JPS5442972B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
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JPS54151959A |
Radiolabeled steroid derivatives having the formula wherein St is a 6-dehydro derivative of a 3-oxo-4,5-dehydro steroid intended for radioimmunoassay, said steroid being saturated in the 1,2-position; R is hydrogen or alkyl of 1 to 3 car...
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JPS5438096B1 |
1289918 Preparation of 3-oxo-#4,6-steroids via 5,6-dihalosteroids G D SEARLE & CO 19 April 1971 [24 Feb 1970] 22333/71 Heading C2U 3-Oxo-#4,6-steroids are prepared by reacting 3-hydroxy-#5-steroids with for example an N-bromoalkanamide o...
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JPS54135762A |
4-Halo-pregn-4-enes of the formula: wherein X<1> is fluoro or chloro; X<2> is hydrogen, fluoro or chloro; X<3> is hydrogen, fluoro, chloro or bromo; X<4> is =C=O or or may be when X<3> is chloro; R<1> is hydrogen, fluoro, chloro, bromo, ...
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JPS54132563A |
Corticosteroids of the formulae wherein: R<1><6> is methyl; and R<1><7> independently is hydrogen, or C2 to C6 linear or branched acyl or R<1><6> and OR<1><7> taken together are the radical (IV) where R<3> is hydrogen, C1 to C6 linear or...
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JPS5495554A |
A process for preparing 17-hydroxy-3-oxo-17 alpha -pregna-4,6-diene-21-carboxylic acid gamma -lactone by contacting 17-hydroxy-3-oxy-17 alpha -pregna-3,5-diene-21-carboxylic acid gamma -lactone with an appropriate halogenating agent in t...
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JPS5492948A |
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JPS5473764A |
Novel 17 alpha -aryl-steroids of the formula I wherein R1 is alkyl of 1 to 3 carbon atoms, R2 is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon atoms...
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JPS5424864A |
19-Nor-pregnahexaenes of formula wherein A is hydrogen, lower alkyl, fluoro or fluoro-substituted methyl; R1 is hydrogen, lower alkyl, or an acyl radical of a carboxylic acid; W is (H, H); (H, lower alkyl); (H, alpha -OR2), with R2 being...
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JPS5347102B2 |
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JPS53141258A |
Compounds of the formula I (I), wherein R2 is hydrogen or an organic acid residue; R3 is methyl or ethyl; R4 is hydrogen or methyl; +TR wherein R1 is lower alkyl; and and when R2 is a dibasic acid residue, the physiologically acceptable ...
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JPS53135963A |
Steroidal anti-inflammatory compounds. More specifically, it relates to certain 17-esters, a 17,21-diester and certain 17,21-orthoesters of cloprednol, (6-chloro-11 beta, 17alpha, 21-trihydroxypregna-1,4,6-triene-3, 20 - dione), and thei...
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JPS53128829A |
An installation for damping vibrations of a drive axle, especially of a rear axle, of motor vehicles, in which the driving pinion of the differential gear which meshingly engages with the spur bevel gear, is driven by way of a universal ...
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JPS53101357A |
Novel and biologically active 11 beta -substituted steroids of the oestrane series are disclosed having the formula (I) wherein (a) R1 is O or ( alpha Y)( beta Z), wherein Y is selected from the group consisting of H, unsaturated aliphat...
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JPS5330710B1 |
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JPS5392753A |
PURPOSE: The title cpds. I [Z is oxo, β-OR1, etc.; R1 is II(R4 is H or alkyl; R2 and R3 are H, 1-8C alkyl, phenyl, etc.; R2 and R3 together form a ring); Q is oxo or III(R5 is H, -COOR4, etc.); the bond between C1 and C2 is single or do...
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JPS5382767A |
Various preparations and the diuretic activity of 7 xi -(alkoxycarbonyl)-6 xi -alkyl/halo-17-hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactones and corresponding 21-carboxylic acids, their salts, and esters are disclo...
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JPS5324417B1 |
Novel process for the preparation of steroids of the pregnane series from certain estrane derivatives which pregnanes are intermediates for cortisone derivatives.
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JPS5346952A |
Novel 19-oxygenated steroids of the 20-spiroxane series of the formula in which R3 is a lower alkyl radical carrying an oxygen-containing functional group and R4 is two hydrogen atoms or an oxo group, and which carry a double bond or a m...
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JPS532868B2 |
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JPS532865B1 |
1,265,444. 1,2 - Methylene - 20 - spiroxanes. MERCK & CO. Inc. 11 May, 1970 [14 May, 1969; 19 March, 1970], No. 22583/70. Heading C2U. Novel steroids of the formulµ (where each X is Cl or F, R1 is H or CH 3 , R is -CH 2 - or -CO- and Z ...
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JPS535150A |
A new process utilizing certain novel intermediates for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The procedure utilizes readily available and inexpensive sarsa...
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JPS52142056A |
A process for the preparation of steroids of the formula: *** in which R1 is a group -NraRb, in which Ra and Rb (which may be the same or different) are C1-6 alcoholic groups or C3 alkenyl- 6 (provided that Ra and Rb together contain 2-7...
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JPS52122356A |
The invention provides a novel general process for the manufacture of 6 beta ,7-methylene-3-oxo-4-ene-steroids by successively (a) reacting a 3 xi ,5 beta -dihydroxy-6-ene-steroid which is optionally etherified or esterified in the 3-pos...
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JPS5289662A |
Novel 6 alpha ,9 alpha ,21-trihalogeno-11 beta -hydroxy-16 alpha or 16 beta -methyl-17 alpha -propionyloxy-pregn-4-ene-3,20-dione compounds of the formula (I) in which X represents chlorine or flourine, R represents the group -CH2CH-, -C...
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JPS5273852A |
2,9 alpha -Dichloro-6 alpha -fluoro-16 alpha -methyl-11 beta ,17,21-trihydroxy- pregna-1,4-diene-3,20-dione compounds of the formula (I) (R1, R2 = OR where R = H, acid residue) have antiinflammatory effects. They are prepared by reacting...
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JPS5259148A |
A process for the preparation of D-homosteroids of the general formula ** (Formula) ** wherein one of the dashed lines in ring A designates a carbon-carbon bond; R1 represents a hydrogen atom or a methyl group; R7 represents a hydrogen a...
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JPS5248657A |
The preparation and valuable biological properties - especially diuretic activity - of 6 beta ,17-dihydroxy-7 alpha -(lower alkoxy)carbonyl-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactones and the corresponding hydroxy acid...
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JPS5214761A |
Novel 11,12-unsaturated 9 alpha -fluorosteroids, especially those of the androstane and pregnane series, with the following constitution in rings B and C it being possible for all the substituents customary in the known pharmacological a...
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JPS51128959A |
Compounds of the general formula (I) wherein R1 represents a hydrogen atom or a lower alkyl group, which contain a double bond in 5-position and a methyl group in 10-position, or three double bonds in the position 1,3 and 5)10), and whic...
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JPS5138719B2 |
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JPS51100068A |
1514621 13-Ethynyl and 13-(2-halovinyl)- steroids CIBA-GEIGY AG 27 Jan 1976 [30 Jan 1975] 03072/76 Heading C2U Novel steroids of the formulµ wherein St is the remaining part of the steroid skeleton which is optionally substituted and wh...
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JPS5176261A |
Preparation and the desoxycorticosterone acetate-blocking, antiestrogenic, and progestational properties of (6S)-17'-hydroxy-3'-oxospiro[oxirane-2,6'-[17 alpha ]pregn-[4]ene]-21'-carboxylic acid gamma lactone and the DELTA 1,4 analog the...
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JPS5175054A |
1492446 4,5-Seco-pregnanes E R SQUIBB & SONS Inc 15 May 1975 [8 Nov 1974] 20694/75 Headings C2C and C2U The invention comprises compounds of formula (wherein A is -CH = CH 2 , -CH 2 CH 3 or -COCH 3 ; X 1 is H, Cl, Br or F; R 1 is H, OH, ...
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JPS5116426B1 |
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JPS5111112B1 |
1325004 Steroid enolization and halogenation RESEARCH INSTITUTE FOR MEDICINE & CHEMISTRY Inc 24 Nov 1970 [24 Nov 1969] 57425/69 Heading C2U A steroid 1,4-diene-3,11-dione is selectively enolized to a 3- or 9(11)-alkali metal enolate ther...
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JPS517664B1 |
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JPS5113772A |
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JPS50142556A |
The present invention relates to novel 11-substituted steroids of the estrane series having the general formula IN WHICH R1 = a free, esterified or etherified hydroxyl group or halogen; R2 = an alkyl group with 1-4 C-atoms; R3 = 0 or ( a...
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JPS5096560A |
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JPS5088061A |
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JPS5077358A |
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JPS5071123A |
A load bearing wall element is provided with recesses or projections at the upper ends of the side edges, for interlocking or engaging projections or recesses respectively of adjacent wall elements. The wall elements may be provided with...
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JPS5069061A |
20-Cyano-17 alpha -H steroids having as the 17-position substituent the group COOR ¦ CHCN ¦ wherein R is H, alkyl of 1-8 carbon atoms or benzyl, having a 13-methyl or 13-ethyl group and which are unsubstituted or substituted with an al...
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JPS5036450A |
Pharmacologically valuable 3-keto-6-azido-4,6-bis-dehydro-steroids are prepared by treating a 3-keto-6 beta ,7-diacyloxy-4-dehydro-steroid, preferably a 3-keto-6 beta ,7 beta -diacyloxy-4-dehydrosteroid, wherein said acyloxy group is a g...
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