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JPS6030517B2 |
Estrene-3,17-diones of the formula wherein X is oxo, or ketalized oxo, preferably alkylenedioxy of 2-6 carbon atoms or o-phenylenedioxy; DELTA IS A CARBON ATOM LINKED TO THE ADJACENT CARBON ATOMS BY A DOUBLE BOND AND TWO SINGLE BONDS; R1...
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JPS6024799B2 |
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JPS6075496A |
7 alpha -Alkoxycarbonyl-3-oxo-17 alpha -pregn-4-ene-21,17-carbolactones and their 21-carboxylic acid salts of the general formula I are described, in which R is an alkyl group with 1 to 4 carbon atoms is a CC single or CC double bond or ...
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JPS6069096A |
Steroids of the formulaand a therapeutic composition containing same which are useful as anti-cancer, anti-obesity, anti-hyperglycemic, anti-autoimmune and anti-hypercholesterolemic agents.
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JPS6034989A |
Novel radioactive estradienes labelled with tritium of the formula I wherein 3H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon ato...
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JPS604198B2 |
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JPS6011499A |
Novel radioactive estradienes labelled with tritium of the formula I wherein 3H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon ato...
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JPS59205400A |
(5 alpha )-20-spirox-1-en-3-ones (I) and 17-hydroxy-5 alpha ,17 alpha -pregn-1-en-3-ones (II) of the formulae (I) and +TR (II) in which X represents O or H2, R2 represents O and R1 represents OH, OMe, OAlk, NH2, NHR3, NR3R4, or R2 repres...
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JPS5940840B2 |
The present invention relates to a dienic derivative of the androstane series having the formula WHEREIN R is a member selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms and alkali metal, R' and R'' are memb...
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JPS59141600A |
PURPOSE: To prepare the titled substance useful as a remedy for prostatic hypertrophy, etc., economically in an industrial scale, by contacting androsta-1,4-diene- 3,17-dione 17-acetal with a radical anion composed of Na and a polycyclic...
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JPS59139400A |
NEW MATERIAL:A compound of formula I (X is H, halogen, hydroxyl; Y is H, lower alkyl, halogen, alkylthio; X and Y may incorporate to form a ring; Z1 is hydroxyl; Z2 is carboxyethyl alkali metal salt; Z1 and Z2 may incorporate together wi...
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JPS5925000B2 |
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JPS5970700A |
7 alpha -substituted-17 alpha -pregn-4-ene-21, 17-carbolactones and -21-carboxylic acid salts of formula I. wherein C1@@@C2 is a C-C single or C=C double bond, R is a saturated or unsaturated, straight-chain or branched aliphatic radical...
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JPS5959700A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS591277B2 |
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JPS58216200A |
Topical antiinflammatory activity is exhibited by steroids having the formulaand the 1,2-dehydro and 15,16-dehydro derivatives thereof, whereinR1 is hydrogen, alkyl, carboxyl, oralkoxycarbonyl;R2 is hydrogen, chlorine, bromine, fluorine,...
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JPS5855154B2 |
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JPS5855158B2 |
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JPS5850239B2 |
1455220 7-Substituted-spiroxane steroids G D SEARLE & CO 12 Sept 1974 [14 Sept 1973] 39799/74 Heading C2U Novel steroids of the formula (wherein " alkyl " contains 1-7 carbon atoms and #1 is optional) are prepared by contacting 41,51 - d...
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JPS5850240B2 |
The present invention relates to a dienic derivative of the androstane series having the formula WHEREIN R is a member selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms and alkali metal, R' and R'' are memb...
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JPS58188900A |
1 alpha ,2 alpha ;6 beta ,7 beta ;15 beta ,16 beta -trimethylene-3-oxo-17 alpha -pregn-4-ene-21,17-carbolactone is prepared from 6 beta ,7 beta ;15 beta ,16 beta -dimethylene-3-oxo-17 alpha -pregna-1,4-diene-21,17-carbolactone with dimet...
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JPS58188899A |
(for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 1. 11 beta-chlorosteroids of general formula I see diagramm : EP0092173,P6,F1 wherein R is hydrogen or an acyl group of an organic carboxylic acid of up to 15 carbon a...
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JPS5844680B2 |
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JPS5842879B2 |
An alkali metal salt of a 3-(17 beta -hydroxyandrosten-3-one 3-acetal-17 alpha -yl)propiolic acid which is useful as an intermediate in the preparation of 3-(3-oxo-7 alpha -acetylthio-17 beta -hydroxyandrost-4-en-17 alpha -yl)-propiolact...
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JPS5842198B2 |
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JPS5840560B2 |
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JPS5839840B2 |
1368005 7-Carboxy steroids and related compounds G D SEARLE & CO 24 Aug 1972 [25 Aug 1971] 39401/72 Heading C2U Novel steroids have the formulµ wherein Z is H, alkali metal, alkaline earth metal/2, ammonium or alkyl; Z1 is H, alkali met...
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JPS5831360B2 |
1451721 11-Oxygenated steroids ROUSSEL UCLAF 4 Jan 1974 [5 Jan 1973] 00354/74 Heading C2U The invention comprises compounds I infra, their preparation from compounds II-VII and their conversion into compounds VIII-X R = Me, Et, Pr ; R1 =...
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JPS58113200A |
New steroidal chiral phosphines of formula (I) wherein R represents a phosphorated group selected between methods for their preparation; catalytic systems comprising metal complexes and the above steroidal chiral phosphines; asymmetrical...
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JPS5829320B2 |
The present invention relates to a process for the preparation of steroidal spirolactones having the formula WHEREIN R1 is a linear alkyl having 1 to 4 carbon atoms and R2 is hydrogen or methyl comprising the steps reacting a compound of...
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JPS5826359B2 |
Novel DELTA 9,11-gonadiene-5 alpha -ols of the formula WHEREIN R is alkyl of 1 to 4 carbon atoms, K is a blocked ketone in the form of a ketal, thioketal or methyloxime, preferably a ketal, and X is the rest of a pentagonal ring optional...
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JPS5883699A |
The title complexes have 3-100 times the water-solubility of the uncomplexed steroids, e.g. spironolactone, nortestosterone, methyltestosterone, androst-4-ene- 3,17-dione, progesterone, Reichstein S, Reichstein S aceate, 16-methyl- Reich...
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JPS5877898A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5877900A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5821640B2 |
4-Androstene-3,17-dione and 1,4-androstadiene-3,17-dione are converted to 3-(17 beta -hydroxy-4-androsten-3-on-17 alpha -yl)-propionic acid lactone in three steps by reaction with propargyl alcohol in the presence of an alkali alcoholate...
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JPS5811880B2 |
15 alpha , 16 alpha -METHYLENE-4-PREGNENES OF THE FORMULA WHEREIN R1 is a lower alkyl and R2 is alkanoyl of 1-18 carbon atoms have gestagenic activity.
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JPS5813515A |
NEW MATERIAL:A compound expressed by formulaI(X and Y2 are H or halogen; Y1 is acetylthio, carboxy or ester thereof, lower alkyl or haogen; Z1 is OH; Z2 is K or Na salt of carboxyethyl; Z1 and Z2 together with the adjacent C form formula...
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JPS584040B2 |
1451721 11-Oxygenated steroids ROUSSEL UCLAF 4 Jan 1974 [5 Jan 1973] 00354/74 Heading C2U The invention comprises compounds I infra, their preparation from compounds II-VII and their conversion into compounds VIII-X R = Me, Et, Pr ; R1 =...
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JPS57197300A |
PURPOSE: To obtain a steroid useful as an intermediate for preparing spironolactone as a diuretic simply in high yield, by reacting a specific acetylene adduct with androst-4-ene-3,17-dione to give a reaction product, followed by acetali...
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JPS57131000A |
Compounds of the formula wherein Q is O or S; R2 is hydrogen or methyl; R6 is hydrogen, fluorine or methyl; either R9 is hydrogen, fluorine or chlorine, R11 is beta -chlorine, beta -hydroxyl or oxo, and the 9,11-bond is a single bond, or...
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JPS576436B2 |
17-Acetals of 3-alkoxyestra-2,5(10)-dien-17-ones are prepared by reacting 17-acetals of 3-alkoxyestra-1,3-5(10)-trien-17-ones with sodium or potassium, liquid ammonia and a tertiary alcohol in the presence of a solvent selected from the ...
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JPS5647200B1 |
1365229 17 - Cyanosteroids ROUSSEL UCLAF 1 June 1972 [1 June 1971] 25576/72 Heading C2U The invention comprises compounds of Formula Ia, Ib, Ic, VI, VII, VIII and IX in the following reaction scheme wherein all conversions are effected i...
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JPS56135499A |
An improved process for the preparation of steroidal DELTA 4,6dienones by the electrochemical dehydrogenation of the corresponding DELTA 3,5enol ethers under basic conditions, using less than stochiometric amounds of a high potential cat...
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JPS56122398A |
17 alpha -Acyloxy-5 alpha -pregnanes (I) and 17 alpha -acyloxy-5 alpha -pregnanes (IV) have an excellent activity split providing high topical anti-inflammatory activity with very low systemic side effects.
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JPS56104900A |
Steroidal-17-spiro-dihydrofuranones, i.e., steroid having in the 17-position a group having the partial structural formula wherein R1 is bromine, chlorine, or fluorine; R2 is alkyl, aryl, or arylalkyl; R3 is hydrogen, alpha -methyl, beta...
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JPS5673099A |
The title compounds of general formula:- wherein the wavy line indicates that hydroxy can be in either the alpha - or beta - position, have diuretic activity. They can be prepared by oxidation of the corresponding 3-alkoxy-6- unsubstitut...
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JPS5614677B2 |
1499822 2 - Bromo - 6# - fluoropregna- 1,4-diene-3,20-diones PIERREL SpA 6 Feb 1975 [27 Feb 1974 5 July 1974 25 July 1974 19 Nov 1974] 8928/74 29984/74 32945/74 and 49982/74 Heading C2U Novel steroids have the formula wherein either X is...
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JPS5613720B2 |
This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N4halogenalkyl-N4-nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation thereof. The invention is also concerned with pha...
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JPS5526157B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
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JPS5569600A |
Hydrocortisone orthoesters of the formula wherein R1 and R2 are independently each H or CH3 and n is 1 or 2 possess antiphlogistic activity.
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