Sugars, Derivatives Thereof, Nucleosides, Nucleotides, Nucleic Acids

Matches 201 - 250 out of 799	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/1996/040712A1	NUCLEIC ACID MEDIATED ELECTRON TRANSFER The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosp...
WO/1996/040253A2	RNA PHOTOCLEAVAGE USING TEXAPHYRINS Methods for photocleavage of a polymer of ribonucleic acid using a photosensitive texaphyrin are provided. A preferred method of use is the site-specific photocleavage of a polymer of ribonucleic acid and a preferred photosensitive texap...
WO/1996/019490A1	VITAMIN B12-CONTAINING SALLOW THORN CONCENTRATES OR EXTRACTS Vitamin B12-containing sallow thorn concentrates or extracts are disclosed, as well as a process for preparing the same and the use of sallow thorn for preventing or treating vitamin B12 deficiencies.
WO/1996/014073A1	TREATMENT OF UROGENITAL CANCER WITH BORON NEUTRON CAPTURE THERAPY Methods and compositions for treating urogenital tumors, and in particular, cancer of the prostate, bladder, and kidney, with BCNT, are disclosed. Any boron-containing compound that is sufficiently lipophilic to pass through the appropri...
WO/1996/012484A1	ANTIANEMIC AGENT CONTAINING IRON AND DIFRUCTOSE According to the present invention, an antianemic agent for the treatment of anemia caused by iron-deficiency containing iron and difructose. Iron and difructose contained in the said antianemic agent may form a complex, and their approp...
WO/1996/009310A1	DERIVATIVES OF CARBOHYDRATES AND COMPOSITIONS CONTAINING THEM The present invention relates to derivatives of phosphorylated carbohydrates and pharmaceutical compositions comprising as a pharmaceutically active ingredient at least one of these compounds.
WO/1996/008503A1	INTERMEDIATES FOR DINUCLEOTIDE AND OLIGONUCLEOTIDE ANALOGUES A compound of formula (I) or salts thereof, where Ro is hydrogen or together with R7O denotes a C1-C15 hydrocarbylidenedioxy group, R1 is hydrogen, R1a or a group of formula (II), R1a is R1b or a protecting group Q, R1b is C1-C20 alkyl, ...
WO/1996/007666A1	MONONUCLEOTIDE AND DINUCLEOTIDE ANALOGUES AND INTERMEDIATES THEREFOR A compound of formula (I) or a pharmaceutically acceptable salt thereof, where R1 is hydrogen, R1a or a group of formula (II), R1a is R1b or a protecting group Q, R1b is C1-C20 alkyl, C2-C20 alkenyl, C3-C10 cycloalkyl, C6-C15 aryl, C7-C1...
WO/1996/006621A1	METAL COMPLEX CONTAINING OLIGONUCLEOSIDE CLEAVAGE COMPOUNDS AND THERAPIES Compositions, formulations and methods for inhibiting messenger RNA translation using anti-sense oligonucleosides containing 5'-cap cleavage moieties are described.
WO/1996/002274A1	CONJUGATES MADE OF METAL COMPLEXES AND OLIGONUCLEOTIDES This invention relates to chemically modified oligonucleotide conjugates that contain a complexing agent or complex that is bound by a connecting component to the oligonucleotides. In this case, the oligonucleotides are modified in a way...
WO/1995/032980A1	SYNTHESIS OF OLIGONUCLEOTIDES Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure (I) are prepared in a...
WO/1995/029916A1	ELECTRON-DEFICIENT PORPHYRINS AND PROCESSES AND INTERMEDIATES FOR PREPARING SAME Electron-deficient porphyrins are provided, as well as processes and intermediates for their preparation. In preferred embodiments, the electron-deficient porphyrins are prepared by condensing pyrrole derivatives and removing water thus ...
WO/1995/027723A1	RECEPTOR MODULATING AGENTS AND METHODS RELATING THERETO Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway. The receptor modulating agents are comprised of a covalently bound rerouting moiety and targeting moiety.
WO/1995/021184A1	SUBSTITUTED PURINES AND OLIGONUCLEOTIDE CROSS-LINKING This invention is directed to novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents -- agents that are capabl...
WO/1995/021183A1	HALOGENATED DERIVATIVES OF 2,3'-O-CYCLOCYTIDINE COMPOUNDS AND PROCESS FOR PRODUCTION THEREOF In one of its aspects, the present invention provides novel compounds of formula (I) wherein: X is a halide; Y is selected from the group consisting essentially of halide, sulfate, acetate, tosyl, mesyl, benzoate and phosphate; R1 is sel...
WO/1995/021180A1	SUBSTITUTED LACTOSE DERIVATIVES AS CELL ADHESION INHIBITORS Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In said formula eac...
WO/1995/019167A1	THERAPEUTIC TREATMENT FOR INHIBITING VASCULAR RESTENOSIS A composition suitable for administration to a warm-blooded animal comprising an antisense oligonucleotide to the C-C chemokine family typified by MCP-1 and MIP-1-Alpha which may or may not be labeled with a radionuclide by means of a ch...
WO/1995/018787A1	SELECTIVE ASYMMETRIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES USING RHODIUM AND IRIDIUM DIPHOSPHINITE CARBOHYDRATE CATALYST COMPOSITIONS A process and catalyst composition are provided for the highly efficient enantioselective hydrogenation of dehydroamino acid derivatives. The catalyst composition comprises rhodium or iridium and a diphosphinite carbohydrate ligand, wher...
WO/1995/015971A2	NUCLEIC ACID MEDIATED ELECTRON TRANSFER The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosp...
WO/1995/015333A1	NUCLEOSIDES AND OLIGONUCLEOTIDES CONTAINING BORON CLUSTERS Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.
WO/1995/014707A1	N-2 SUBSTITUTED PURINES This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents -- agents that are capable of s...
WO/1995/009848A2	POLYAZACYCLOALKANES AS DICHELANTS This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula (V) (wherein each X which may be the same or differ...
WO/1995/008644A1	SELF-SUSTAINED SEQUENCE REPLICATION ELECTROCHEMILUMINESCENT NUCLEIC ACID ASSAY This invention relates to an improved process for detecting and quantifying a desired nucleic acid sequence. This process involves synthesizing single stranded RNA, single stranded DNA, double-stranded DNA followed by detection using an ...
WO/1995/006474A1	THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain embodiments, the compounds of the invention...
WO/1995/005202A1	IODINATED BORANE CAGE MOLECULES AS X-RAY CONTRAST MEDIA Highly iodinated borane and carborane cage molecules, having from 60 % to 90 % w/w iodine, are disclosed as new and useful X-ray contrast media when combined with a pharmaceutically acceptable carrier. The inclusion of appropriate functi...
WO/1995/004065A1	PROCESSES AND INTERMEDIATES FOR PHOSPHOROUS-CONTAINING COVALENT LINKAGES Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic interm...
WO/1995/001363A1	METHYLPHOSPHONIC ACID ESTER, PROCESS FOR PREPARING THE SAME AND ITS USE Compounds having the formula (I), in which the substituents R', Y, W and R have the meanings cited, have in vivo the activity of the active substance residue W with improved pharmacokinetics.
WO/1994/029324A1	SILOXANYL-MODIFIED POLYHYDROXYLATED HYDROCARBONS Described are siloxanyl-modified compounds, their preparation and their use as surface-active and surface-modifying agents, particularly for use in plant protection, or in the manufacture of surface-active or surface-modifying agents.
WO/1994/028907A2	USE OF CORRINOIDS IN TOPICAL TREATMENT OF SKIN DISEASES The invention pertains to the use of compounds of formula (I), where R is CN, OH, CH3 or H2O, in topical treatment of skin diseases and hair-growth disorders, and to a pharmaceutical preparation which contains, besides common carriers an...
WO/1994/029322A1	CATIONIC SILOXANYL-MODIFIED POLYHYDROXYLATED HYDROCARBONS Described are cationic siloxanyl-modified compounds, their preparation and their use as surface-active and surface-modifying agents or in the manufacture of surface-active or surface-modifying agents.
WO/1994/029323A1	ANIONIC SILOXANYL-MODIFIED POLYHYDROXYLATED HYDROCARBONS Described are anionic siloxanyl-modified compounds, their preparation and their use as surface-active and surface-modifying agents.
WO/1994/006811A1	SILOXY OLIGONUCLEOTIDE ANALOGS A class of oligodeoxyribonucleotide and oligoribonucleotide analogs containing one or more stable internucleotide siloxy linkages is presented here. The linkages, in which the phosphodiester group is replaced by a siloxy group, are neutr...
WO/1994/005681A1	NEW ACETALS OF KETOPHOSPHAMIDES AND ALKYLGLYCOSIDES New acetals of ketophosphamide and alkylglycoside have the general formula (I), in which R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning given in the description. Also disclosed is a process for preparing the same and their use as hig...
WO/1994/004614A1	METAL-MEDIATED CROSS-COUPLING WITH RING-METALATED PORPHYRINS Porphyrins substituted with, for example, vinyl and acetylene groups are provided, along with polymers containing the same. In preferred embodiments, the substituted porphyrins are prepared by coupling halogenated porphyrins with anionic...
WO/1994/001444A1	PHOSPHITE-BORANE COMPOUNDS, AND METHOD OF MAKING THE SAME Phosphite-borane compounds wherein the borane moiety covalently bonded to the phosphorous atom is a BH3 moiety, and/or wherein the phosphorous atom has covalently bonded thereto a natural or synthetic nucleoside. The phosphite-borane com...
WO/1994/001413A1	BORONATED COMPOUNDS A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds ...
WO/1994/001440A1	BORONATED PHOSPHORAMIDATE COMPOUNDS A class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated phosphoramidates, and boronated nucleosides, and oligomers thereof. The compounds are boronated by an aminoalkyl substituted p...
WO/1994/000465A1	NOVEL SUCROSE LIGANDS, METHODS FOR THEIR PREPARATION, PLATINUM COMPLEXES DERIVED THEREFROM, AND METHODS FOR THEIR USAGE The invention relates to novel sucrose ligands, methods for their preparation and their use as ligands for complexation with metals or metal containing compounds, as bulking agents or to make novel crosslinking agents. Bis(platinum) comp...
WO/1994/000477A1	SUBSTITUTED LACTOSE DERIVATIVES AS CELL ADHESION INHIBITORS Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In formula (I), R1 ...
WO/1993/025566A1	DEUTERATED NUCLEOSIDES The preparation of deuterated nucleoside and nucleotide units for RNA and DNA synthesis is described. Preparation of the deuterated sugar residue is also described. The deuterated units are used to synthesize strands of RNA and DNA where...
WO/1993/023414A1	A PROCESS FOR THE PREPARATION OF RIBONUCLEOTIDE REDUCTASE INHIBITORS The present invention is directed toward a novel process of 2'-exocyclic vinylfluoride derivatives of cytidine analogues (I) for use as ribonucleotide reductase inhibitors, wherein V is oxy or methylene and Y is hydrogen, C¿1?-C¿4? alk...
WO/1993/017717A1	COMPOSITIONS AND METHODS FOR MODULATING RNA Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably compris...
WO/1993/018051A1	PROCESS FOR PRODUCING NUCLEOSIDE DERIVATIVE A process for producing a nucleoside derivative (1) by reacting a substituted 2,3-dihydrofuran derivative (2) with an organohalogen compound (3) containing a group 16 element of the periodic table to give a substituted 2-halotetrahydrofu...
WO/1993/007883A1	DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE AND OTHER PROPERTIES Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitam...
WO/1993/002094A1	A PROCESS FOR THE PREPARATION OF DEMETHYLEPYPODOPHYLLOTOXIN Disclosed herein is a process for producing novel DMEP-beta-D-glucosides of formula (I), wherein R1 is lower alkanoyl group, haloacetyl group, or both R1, taken together, form an alkylidene, arylalkylidene or heteroarylalkylidene group; ...
WO/1993/001204A1	METHOD AND COMPOUNDS FOR RNA SYNTHESIS A method and compositions are provided for synthesizing polynucleotides wherein the exocyclic amino groups of 5'-O-protected-2'-O-alkylsilyl-adenosine phosphoramidite and 5'-O-protected-2'-O-alkylsilyl-guanosine phosphoramidite monomers ...
WO/1992/021689A1	SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing silyl substituted alcohols include hydrosilation of a vin...
WO/1992/021690A1	PURINE BASE MODIFIED 2'-DEOXYRIBONUCLEOSIDES, USE IN TRIPLEX FORMING OLIGONUCLEOTIDES AND PROCESS FOR PREPARING THE SAME There are provided purine-base modified guanosine analogues, for example 2'-deoxy, and then ribonucleosides for incorporating into triplex-forming oligonucleotides. Also provided are triplex-forming oligonucleotides for binding into stra...
WO/1992/020650A2	PHOSPHITE-BORANE COMPOUNDS, AND METHOD OF MAKING AND USING THE SAME Phosphite-borane compounds of formula (I) wherein each R1 is independently selected from: H; C1-C10 alkyl; alkylaryl; aralkyl; aryl; monovalent metal ions; nucleosides; and quaternary ammonium ions, (R4)4N+, in which the substituents R4 ...
WO/1992/018522A1	OLIGODEOXYNUCLEOTIDES AND OLIGONUCLEOTIDES USEFUL AS DECOYS FOR PROTEINS WHICH SELECTIVELY BIND TO DEFINED DNA SEQUENCES Improved DNA structures are disclosed which contain target sequences which bind to control proteins (such as the CREB protein). The structures of the present invention are stable to degradation, and are effective as decoys for control pr...

Matches 201 - 250 out of 799	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >