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WO/2005/061523A1 |
The invention relates to compounds that are designed to mimic the structure of GAGs; methods for the preparation of the compounds; compositions comprising the compounds; and use of the compounds and compositions thereof for the anti-angi...
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WO/2005/056516A1 |
The present invention relates to novel compounds corresponding to the general formula (I) below: to compositions containing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alterna...
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WO/2005/054264A2 |
Compounds and methods are provided for modulating in vivo and in vivo processes mediated by selectin biniding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g. inhibi...
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WO/2005/044758A1 |
An on-column process by which various radioactive-fluorine-labeled compounds can be obtained in a high yield. The process comprises a step in which [18O]water containing [18F]fluoride ions is introduced into a column packed with an anion...
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WO/2005/016514A2 |
Methods are disclosed for providing a library of composite or novel composition samples on a support. The method involves depositing one or more components as concentration gradients on the surface of the support. The concentration gradi...
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WO/2005/010053A1 |
Aminated complex-type sugar chain derivatives represented by the general formula (1): wherein R1 is -NH-(CO)-CH2X, -NH-(CO)-(CH2)b-CH2X, isothio- cyanato, -NH-(CO)a-(CH2)b-CO2H, or -NH-(CO)a-(CH2)b-CHO; X is halogeno; a is 0 or 1; b is a...
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WO/2005/003374A2 |
An improved process for the preparation of 2'-modified nucleosides and 2'-deoxy-nucleosides, such as, β-L-2'-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2'-deoxynucleoside th...
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WO/2004/106352A1 |
A process for producing a tetra-O-acetylaldohexopyranose represented by the formula (VI) which comprises reacting a penta-O-acetylaldohexopyranose represented by the following formula (V) with a mixture of a hydrazine compound represente...
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WO/2004/104016A1 |
A process for the preparation of 4, 1', 6'- trichoro-4, 1', 6'-trideoxygalactosucrose is characterized by that raw material sucrose is added into N,N-dimethylformamide, and transesterification is conducted between sucrose and ethyl aceta...
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WO/2004/099273A1 |
The invention relates to water-soluble or water-dispersible polymers made from monoethylenically-unsaturated saccharide monomers, comprising a polymer of (A) 5 to 100 wt. % of at least one ester, selected from the group of monoacrylate a...
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WO/2004/093866A1 |
The present invention provides a novel process for preparation of the tannate salt of gabapentin for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications a...
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WO/2004/092192A1 |
The present invention relates to compounds of the following general formula: (I) wherein R1 and R2 are fatty acyl groups, a process to extract them from Mycobacterium tuberculosis, and their use in the treatment or the prophylaxis of tub...
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WO/2004/087725A1 |
The present invention relates to polymerizable monomers for applications in medicine and biotechnology and synthesis thereof. The polymerizable ligands containing NAcetyl Glucosamine bind more strongly to lysozyme than NAG itself. The bi...
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WO/2004/081018A1 |
The present invention concerns Pyridinium-Betain compounds of the following general formula (A) R1 is H; R2 is a chemical group formed by a sugar pentose or hexose ring, substituted at C5or C6, respectively, with an acid residue taken fr...
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WO/2004/077938A2 |
Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a p...
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WO/2004/075848A2 |
The present invention provides pharmaceutical compositions for the treatment of cancer and inhibiting an increase in the volume or mass of a tumor, and methods for the treatment of cancer and inhibiting an increase in the volume or mass ...
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WO/2004/074300A2 |
The present invention discloses novel and improved nucleosidic and nucleotidic compounds that are useful in the light-directed synthesis of oligonucleotides, as well as, methods and reagents for their preparation. These compounds are cha...
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WO/2004/071515A1 |
Process for the preparation of monosaccharide derivatives, providing industrial advantages, including convenience, safety, and economic advantages. The monosaccharide derivatives can be used for the inhibition and prevention of cell adhe...
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WO/2004/069851A1 |
The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of Formula (I) useful in the synthesis of nucleotides.
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WO/2004/065399A1 |
It is intended to provide a novel hollow fiber type organic nanotube and a microtube which can be conveniently produced within a short time and are widely usable. An N-glycoside type glycolipid represented by the following general formul...
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WO/2004/062599A2 |
Compounds that are adjuvants and immunoeffectors are described and claimed. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for us...
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WO/2004/050676A1 |
A method in which a glucide, examples of which include a monosaccharide, an oligosaccharide, a polysaccharide, a composite saccharide comprising any of these saccharides and a protein or lipid bonded thereto, a polyalcohol, an aldehyde, ...
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WO/2004/043945A1 |
A method for purifying isoflavones glycosides of genistin and daidzin from impurities present in a soy isoflavones concentrate. The method includes digesting a soy isoflavones concentrate with an acidic solution and separating insoluble ...
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WO/2004/033474A1 |
An acetylated N-acetylglucosamine derivative represented by the following general formula (1) and a hyaluronic acid production promoter containing the same and a skin preparation for external use containing the same. General formula (1):...
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WO/2004/033475A1 |
A tyrosinase activity controlling agent containing, as the active ingredient, a compound having an activity of inhibiting or promoting tyrosinase, an external preparation containing the controlling agent, and a process for producing the ...
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WO/2004/019992A1 |
Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R1)-L-M wherein: A is a bond, -C(O)- or...
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WO/2004/018492A1 |
A new process for producing a levovirin intermediate of the formula is described. Levovirin is a nucleoside antiviral.
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WO/2004/014147A1 |
Disclosed are methods for increasing fecal hair excretion and for treating hairballs in a mammal by administering a composition comprising polyol fatty acid polyester. Further disclosed are veterinary or food compositions comprising the ...
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WO/2004/013342A1 |
Novel substances of compounds PF1237A, PF1237B and PF1237M exhibiting antifungal activity; a process for producing these novel compounds through culturing of PF1237 producing strain belonging to the genus Fusarium; and an antifungal agen...
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WO/2004/011662A1 |
A persulfated oligosaccharide acting on selectins and chemokine. Namely, a saccharide compound interacting with L-selectin, P-selectin and chemokine; medicinal compositions and remedies or preventives for diseases the onset of which rela...
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WO/2004/011423A2 |
A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structura...
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WO/2004/009094A1 |
Methods for modulating diabetes, impaired glucose tolerance, gestational diabetes and glucose resistance in a mammal, particularly a human. In one embodiment the method comprises administering a gallotannin composition to a mammal in nee...
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WO/2004/005308A2 |
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are prod...
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WO/2004/002997A1 |
The present invention relates to a low temperature, solvent-free trans-acidolysis process for preparing surface-active carbohydrate fatty-acid esters comprising the steps of reacting acylated carbohydrate with free fatty acid in the pres...
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WO/2003/104178A1 |
Where Y, R¿1?-R¿8? and R¿101?-R¿108? are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting M...
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WO/2003/104203A1 |
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of t...
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WO/2003/104247A2 |
The invention relates to mannose 1-phosphate derivatives and to pharmaceutical or dietary agents, which contain the same and which are used for treating disorders of glycosylation and, in particular, for treating CDG-1a. These derivative...
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WO/2003/099837A1 |
This invention relates to processes for the production of purified, partially esterified polyol fatty acid polyesters and the compositions derived from those processes. The purified, partially esterified polyol fatty acid polyesters of t...
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WO/2003/099834A2 |
This invention relates to processes for the production of purified, partially esterified polyol fatty acid polyesters and the compositions derived from those processes. The purified, partially esterified polyol fatty acid polyesters of t...
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WO/2003/099838A1 |
This invention relates to processes for the production of purified, partially esterified polyol fatty acid polyesters and the compositions derived from those processes. The purified, partially esterified polyol fatty acid polyesters of t...
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WO/2003/089010A1 |
The present invention relates to new anionic glycodendrimers having new biological activity, processes for preparing them and their use in medicine including veterinary medicine.
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WO/2003/080678A1 |
A modified polysaccharide, in particular a modified Neisseria meningitides serogroup A polysaccharide, which retains immunogenicity but has improved stability. Typically, the modified polysaccharide is prepared by reacting a capsular pol...
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WO/2003/076454A1 |
This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from ea...
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WO2002028424A9 |
The present invention is directed to a "Kyberdrug" and to a pharmaceutical composition containing an effective amount of the Kyberdrug and a pharmaceutical carrier therefor, and its medicinal use as an immune modulating drug exhibiting a...
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WO/2003/059866A1 |
Compounds represented by the general formulae (I-1), (I-2), (I-3) and (I-4) and having excellent antitumor activity: (I-1) (I-2) (I-3) (I-4) wherein R1, R2, R3, m, n and R4 are each as defined in the description.
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WO/2003/059298A1 |
The invention relates to the alk(en)yl olligoglycoside betaine ester quaternaries of the formula R1O(G)nOCOCR2R3NR4R5R6 (I), wherein R1 represents an alk(en)yl group with 4 to 22 carbon atoms, G represents a sugar residue with 5 to 6 car...
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WO/2003/057894A1 |
There is described a process for the selective deprotection of hydroxy groups of nucleosides polyesters by selective hydrolysis of said polyesters in an aqueous solvent in the presence of a lipase of animal or microbial origin immobilize...
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WO/2003/057896A1 |
The present invention relates to a process for preparation of a product compound of the Formula (I), where R1 is an acyl group, R2 is H, an N−alkylated amino sugar, or a non−basic sugar moiety, and R3 is H, OH, or OCH3. The process i...
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WO/2003/045967A1 |
This invention is directed to compounds of formula (1) and their pharmaceutically acceptable salts, wherein R?1¿, R?2¿, and R?3¿ are as defined herein; intermediates for the synthesis of such compounds; and methods of using such compo...
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WO/2003/044032A1 |
A sugar derivative which has altered properties of a cyclic tetrasaccharide so as to expand the range of applications of the compound represented by the chemical formula (1); a composition containing the derivative; and a process for pro...
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