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WO/2001/040240A2 |
The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fat...
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WO/2001/037790A1 |
Disclosed is the use of alkyl- and/or alkenyloligoglycoside fatty acid esters for improving the sensory evaluation of emulsions.
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WO/2001/036436A1 |
A means and method for increasing or inhibiting the secretion of cytokines using gallotannins and ellagitannins is described. The preferred cytokine release inhibiting compounds are dimeric gallotannins having a linker molecule that misa...
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WO/2001/036433A2 |
New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid structures (3) and (4) that are not found...
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WO/2001/036435A1 |
A $g(b)-D-glucofuranose compound which is 1,2,3,5,6-penta-O-propanoyl-$g(b)-D-glucofuranose, preferably in crystalline form, is prepared from D-glucose. The compound is prepared by reacting D-glucose with boric acid, or an equivalent the...
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WO/2001/034617A2 |
Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are pho...
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WO2000064915A9 |
Antibacterial disaccharide and trisaccharide compounds structurally related to the moenomycin class of antibiotics in which the saccharide is covalently attached to a lipid, such as a C4-C30 aliphatic alcohol, via a bridging phosphorus a...
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WO/2001/022971A1 |
Sebum production inhibitors which contain as the active ingredient compounds having glucuronic acid derivatives and glucosamine derivatives in the structure as represented by general formula (1) or pharmacologically acceptable salts ther...
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WO/2001/015734A2 |
The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surg...
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WO/2001/014339A2 |
Heterocyclic aromatic amides (HAA) according to Formula (I) wherein X¿1?-X¿4?, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are useful as antifungal agents.
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WO/2001/014394A2 |
Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a hydrogenated malto-oligosaccharide, and the...
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WO/2001/005769A2 |
Heterocyclic aromatic amides having a hydroxy group adjacent to the amide functionality of Formula (I) wherein (a) represents a 5- or 6- membered heterocyclic aromatic ring in which (i) each of X¿1?-X¿4? is O, S, NR', N, CR' or a bond;...
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WO/2001/002018A2 |
The invention relates to a compound of the general formula (I) X(B)¿m?, wherein X is a unit of the value m and the members B are the same or different and represent K-R, wherein K represents a bond or A?1¿-(A?2¿-A?3¿)¿k?-sp, wherein...
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WO/2001/000217A1 |
Medicinal compositions for preventing or treating diarrhea which contain, as the active ingredient, siastain B or its derivatives having a $g(b)-glucuronidase inhibitory activity and are useful as preventives or remedies for diarrhea whe...
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WO/2000/078764A1 |
A process is provided for the manufacture of morphine-6-glucuronide and related compounds of the general structure shown in Formula (1), wherein optionally substituted morphine is conjugated with an optionally substituted member of a new...
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WO/2000/078353A2 |
An aqueous adjuvant composition comprising an attenuated lipid A derivative and a non-immunostimulatory surfactant or surfactants enhances the immunological response in a warm blooded animal to a protein antigen. Attenuated lipid A deriv...
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WO/2000/068408A1 |
The invention relates to the production of polyoles from corresponding polyoles and carboxylic acids containing an aromatic ring, whereby said polyoles are esterified on the primary OH-group. The aim of the invention is to improve the se...
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WO/2000/064918A1 |
A process for the production of cladribine, 2-chloro-2'-deoxyadenosine, is provided which involves the direct glycosylation of 2-chloro-6-aminopurine with 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-$g(a)-D-erythropentofura
nose. The process is ...
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WO/2000/064463A1 |
The present invention relates to psychotropic polygalasaponins and its extraction and isolation from the roots of $i(Polygalae tenuifolia). The inhibitory activity of the extract from the roots of $i(Polygalae tenuifolia) on stereotyped ...
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WO/2000/058326A2 |
The invention relates to a method for the production of etoposide wherein 2,3 - diphenoxyacetyl -1-O-triethylsilyl -$g(b)-D- glucopyranoside is condensed with 4'-phenoxyacetyl-4'-demethylepipodophyllotoxine.
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WO/2000/056745A1 |
There is provided a derivatised anhydrofructose comprising a hydrophobic group linked (directly or indirectly) to a C of an anhydrofructose moiety.
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WO/2000/056683A1 |
The invention relates to a method for producing alcohol surfactants and alcohol ether surfactants which are inter alia suitable as surfactants or for producing surfactants. According to the inventive method, olefinic mixtures with a defi...
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WO/2000/047595A1 |
Compounds represented by general formula (I), which have excellent macrophage inhibiting effects and are thus useful in the prevention or treatment of inflammation, autoimmune diseases or sepsis: wherein R?1¿ and R?3¿ are each C¿1?-CÂ...
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WO/2000/044760A1 |
Processes for the synthesis of polyol fatty acid polyester by transesterification of a polyol comprise reacting polyol with a first portion of fatty acid lower alkyl ester to provide a first step reaction product in which substantially a...
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WO/2000/043344A1 |
The invention relates to $g(a)-halogenated acid esters of polyvalent, but at least trivalent, alcohols which can be used as atom transfer radical polymerization initiators. Using said initiators block copolymers having branched structure...
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WO/2000/042053A1 |
The present application relates to a group of novel substituted pentose and hexose monosaccharide derivatives, not previously disclosed, which exhibit potent anti-cell adhesion and anti-inflammatory activities. Methods of preparation, ph...
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WO/2000/042054A1 |
This invention relates generally to compounds and processes for synthesizing derivatives of 2-3-O- isopropylidene-$g(a) -L-xylo-2- hexulofuranosonic acid, of formula (I) compounds of this invention are useful, inter-alia, for the inhibit...
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WO/2000/040589A2 |
The invention relates to novel compounds from the class of the macrolide antibiotic oleandomycin of general formula (I).
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WO/2000/039141A1 |
The application relates to the design and synthesis of novel hexasaccharides of general formula (I), wherein: each R is independently selected from hydrogen, an alkyl or substituted alkyl group, an acyl or substituted acyl group, a phosp...
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WO/2000/039140A1 |
Compounds represented by formulae (I), (V) and (X), which are novel siastatin B derivatives having potent glycosidase inhibitory activities, are synthesized by a novel process. The compounds of the formulae (I), (V) and (X) have potent i...
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WO/2000/039137A2 |
New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excelle...
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WO2000018777A9 |
The invention is directed to a method for synthesizing C-glycosides of ulosonic acids, as well as intermediates thereof and C-glycosides prepared by this method.
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WO/2000/036138A1 |
A method is described for high-sensitivity screening for the presence of inhibition of at least one enzyme in the biosynthetic pathway to terpenoids via 1-deoxy-D-xylulose 5-phosphate in plants by incubating an aqueous suspension of plas...
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WO/2000/031093A2 |
This invention provides smooth muscle cell proliferation inhibitors of formula (I) having a structure wherein Y is C or N; where n is 0 - 3; X is (A) wherein R?1¿, and R?2¿ are each independently, hydrogen, alkyl of 1 to 6 carbon atoms...
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WO/2000/031059A1 |
The invention concerns compounds of formula (I) wherein: A represents R¿1? or(O)R¿1? where R¿1? represents an alkyl group comprising 1 to 30 carbon atoms, linear or branched, saturated or unsaturated, capable of being partly or totall...
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WO/2000/031094A2 |
This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure (a) wherein Y is C or N; where n is 0 - 3; X is (II); or a pharmaceutically acceptable salt thereof.
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WO/2000/028130A2 |
The invention relates to a method for the hydrophilic finishing of fibres which exclusively contain polyolefins or polyester. A mixture which contains (a) mostly polyolefins or polyester and (b) 0.01 to 10 wt.% in relation to the sum of ...
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WO/2000/026384A1 |
The subject invention lies in the field of vaccines. Specifically new compounds that can be used as adjuvants are provided. Recombinant LPS having a reduced number of secondary acyl chains per molecule of LPS vis a vis the corresponding ...
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WO/2000/025787A1 |
The present invention relates to pharmaceutical compositions containing poly(ADP-ribose) glucohydrolase inhibitors, also known as PARG inhibitors, and methods of using the same for inhibiting or decreasing free radical induced cellular e...
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WO/2000/021954A1 |
The invention relates to novel heterocyclyl-methyl-substituted pyrazole derivatives, to methods for producing them and to their use as medicaments, especially as medicaments for treating cardiovascular diseases.
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WO/2000/015044A1 |
Elevated blood lipid level-related diseases such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases can be effectively treated or prevented by administering a pharmaceutical composition comprising an effect...
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WO/2000/014097A2 |
The invention relates to compounds of formula (I), wherein M, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, B5, B6, K1 and K2 have the meanings given in the description. Said compounds are novel, effective tryptase inhibitors.
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WO/2000/011010A1 |
The invention concerns a novel phosphoglycolipid compound. The compound of the subject invention is 2- Deoxy-6-$i(O)- [2-deoxy-4-$i(O) -phosphono-3-$i(O) -[($i(R))-3- tetradecanoyloxytetradecanoyl] -2-[($i(R))-3- octadecanoyloxytetradeca...
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WO/2000/009528A1 |
Process for synthesizing and purifying polyol fatty acids polyesters or other nondigestible fats selected from the group of esterified linked alkoxylated polyols and esterified epoxide extended polyols, in which unreacted lower alkyl est...
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WO/2000/008039A1 |
Cellobiuronic acid may be prepared by hydrolysis of gellan. The method provides embodiments expressed in terms of amounts of cellobiuronic acid produced, amounts of gellan gum hydrolyzed and amounts of cellobiuronic acid present in fract...
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WO/1999/065480A1 |
Preventives and/or remedies for HIV infection which contain as the active ingredient compounds represented by general formula (J); and glucopyranose derivatives represented by general formula (W) or nontoxic salts thereof (in these formu...
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WO/1999/064430A2 |
The invention provides a novel method for synthesising M6G, and intermediates therefor. In order to synthesise M6G the major problem to overcome is to obtain the glycoside linkage with very high $g(b)-selectivity since prior methods prod...
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WO1999029705A9 |
The present invention provides a series of compounds in the form of chemically and physiologically stable glycomimics or glycoepitopes that serve to functionally mimic the active features of biologically important oligosaccharides, such ...
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WO/1999/048946A2 |
A process for synthesizing polyol fatty acid polyesters comprising the steps of (1) mixing ingredients comprising (a) unesterified first polyol having hydroxyl groups, (b) second polyol esterified with fatty acids, (c) basic catalyst, an...
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WO/1999/049070A1 |
A process for removing digestible fat from a crude reaction mixture comprising nondigestible fat and at least one digestible fat selected from the group consisting of digestible fats having fatty acid chains, comprising the steps of: (1)...
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