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WO/1999/020631A1 |
3-Halogenomethylcephem compounds represented by general formula (2) or salts thereof, produced by reacting a 7-amino-3-halogenomethylcephem compound represented by general formula (1) or a salt thereof with a phenol derivative to remove ...
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WO/1999/019330A1 |
Cephem compounds having an antibacterial activity and represented by general formula (I) or salts thereof, wherein R?1¿ represents a group represented by any of formulae (a), (b), and (c) and (wherein R?5¿, R?7¿, and R?8¿ each repres...
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WO/1999/015532A1 |
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between 3 and 8 at a temperature between -5 and 20 °C and ...
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WO/1999/015531A1 |
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between (3) and (8) at a concentration such that FG remains...
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WO/1999/010352A1 |
Cephalosporin crystals highly stable during storage under economical conditions for a long time, which are obtained by crystallizing oily cephalosporin in an alcohol-containing solvent.
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WO/1999/006048A1 |
Provided by the present invention are cephem derivatives represented by general formulae (IA) or (IB) or (IC) wherein Ar is an optionally substituted lipophilic phenyl, naphthyl or pyridyl group; L¿1? and L¿2? are (C¿1?-C¿6?)...
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WO/1999/003465A1 |
Novel excellent antibiotics containing as the active ingredient indole derivatives represented by the general formula (I), inner salts or pharmacologically acceptable salts of the same, or hydrates thereof exhibit excellent antibiotic ac...
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WO/1998/058933A1 |
Cephalosporin compounds (I) represented by general formula (I) or pharmaceutically acceptable salts thereof: wherein R?1¿ represents hydrogen or an amino-protective group; R?2¿ represents hydrogen, lower alkyl or a hydroxy-protective g...
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WO/1998/058931A1 |
A process for producing $g(b)-lactam derivatives, characterized by treating a $g(b)-lactam derivative having a protected carboxyl group and represented by the general formula (1): A-COO-X (wherein A is a $g(b)-lactam derivative residue; ...
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WO/1998/058932A1 |
Z-Isomers of compounds of general formula (IV): [wherein R?1¿ is 2-(2-N-protected aminothiazol-4-yl)-2-alkoxyiminoacetyl or the like, R?2¿ is hydrogen or the like; R?3¿ is hydrogen, a carboxyl-protecting group or the like; and R?8¿ i...
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WO/1998/055485A1 |
A process for producing 3-alkenylcephem compounds represented by general formula (3) characterized in that an iodination reagent, an alkali metal hydroxide or carbonate, an arylphosphine, and an aldehyde represented by the general formul...
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WO/1998/055484A1 |
A process in the isolation of 7-aminocephalosporanic acid (7-ACA) of formula (I) from an alkaline, neutral or slightly acidic medium in the presence of an additive, e.g. selected from the group comprising organic carboxylic acid esters, ...
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WO/1998/048037A1 |
The invention relates to a method for controlling the solubility of a $g(b)-lactam nucleus having general formula (I) wherein R�0? is hydrogen or C�1-3? alkoxy; Y is CH�2?, oxygen, sulfur, or an oxidized form of sulfur; and Z is (a...
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WO/1998/045299A1 |
Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use in the purification of impure cefdinir.
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WO/1998/043980A1 |
This invention relates to a process for preparing an amorphous cefuroxime axetil having a low melting point, more particularly, in which a solid medium including cefuroxime axetil homogeneously is prepared and wherein water is added at l...
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WO/1998/043981A1 |
A compound of formula (I), wherein W, V, R�1?, R�5?, R�2?, R�3? and R�4? have various meanings, a process for their production and their use as a pharmaceutical.
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WO/1998/032766A1 |
The present invention provides substituted amino bicyclic-$g(b)-lactam penam derivatives and substituted amino bicyclic-$g(b)-lactam cepham derivatives and their diastereoisomers of general formula (I) as well as compositions containing ...
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WO/1998/031685A1 |
Crystalline 2-(aminothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)ace
tic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetam...
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WO/1998/029416A1 |
Cephem compounds of general formula (I), wherein formula (a) represents benzene, pyridine, pyrazine or a five-membered aromatic heterocycle (containing oxygen or sulfur as the ring atom), provided when is a five-membered aromatic heteroc...
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WO/1998/028933A1 |
A portable messaging unit (130) roams within zones (105, 110, 115) of a communication system (100). The portable messaging unit (130) includes a processor (220) that determines whether the portable messaging unit (130) is registered in a...
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WO/1998/025621A1 |
The present invention provides for the inclusion of small amounts of water in oil suspensions of active drugs, such as ceftiofur of formula (II), particularly the hydrochloride salt of ceftiofur. The resulting suspensions have improved r...
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WO/1998/024793A1 |
The invention provides a compound of formula (I) wherein R?1� to R?5�, n, X, Y and Z have any of the values defined in the specification; or a pharmaceutically acceptable salt thereof; for use in medical therapy, and in particular, f...
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WO/1998/023621A1 |
Provided are cephem derivatives represented by general formula (I) wherein Q is an optionally substituted pyridinium group connected to the sulfur atom via a ring carbon atom; X is halogen; Y is hydrogen or halogen; L?1� is a furan gro...
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WO/1998/022469A1 |
A process for efficiently and economically producing cephem intermediates wherein the side chain at the 7-position is fluorinated and cephem antibiotics wherein the side chain at the 7-position is fluorinated and the side chain at the 3-...
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WO/1998/012200A1 |
As a novel substance is provided a new, crystalline substance of Cefditoren pivoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step ...
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WO/1998/006723A1 |
Celfixime in form of a salt with dicyclohexylamine, e.g. a bis-dicyclohexylammonium salt, a process for its preparation and its use in the purification of cefixime.
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WO/1998/004565A1 |
The cephalosporin intermediate, desacetyl 7-glutaryl ACA, is obtained in the form of a concentrated aqueous solution from an aqueous solution containing said intermediate in less concentrated form by solvent extraction using cyclohexanon...
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WO/1998/004564A1 |
The cephalosporin intermediates, desacetyl 7-glutaryl ACA and desacetyl cephalosporin D, are obtained in the form of a concentrated aqueous solution from an aqueous solution containing said intermediates in less concentrated form by solv...
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WO/1998/004732A1 |
Disclosed is a process for the synthesis of $g(b)-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
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WO/1997/049670A1 |
The invention concerns new catechol derivatives of the general formula (I), in which azomethine-carboxylic acid rests, azobenzene-carboxylic acid rests, benzhydrazon rests, aminobenzoic acid rests and amino acid rests or dipeptides, pyrr...
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WO/1997/047627A1 |
A process for producing 3-norcephem compounds represented by general formula (2) characterized by reacting a halogenated 'beta'-lactam compound represented by general formula (1) with a hydride reagent in the presence of a monovalent cop...
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WO/1997/047301A1 |
A new crystalline form of potassium clavulanate is disclosed. Also disclosed are a process for producing the new crystalline form of potassium clavulanate, pharmaceutical compositions containing it and methods of treating bacterial infec...
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WO/1997/044000A2 |
The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof w...
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WO/1997/042177A1 |
A new process is described for the synthesis of ureide derivatives having formula (I) where the P ring is a saturated or unsaturated nitrogen heterocycle with 5 or 6 members, possibly containing, in addition, one or more hetero-atoms cho...
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WO/1997/041128A1 |
The present invention relates to a cephem compound of formula (I) wherein R1 is amino, etc; R2 is halogen, etc; R3 is a group of formula (a) (wherein R6 is hydrogen, etc); R4 is a group of formula (b) (wherein R7 is hydroxy(lower)alkyl, ...
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WO/1997/039002A1 |
A method of producing a compound, 7-aminocephalosporanic acid derivative, which is useful as a starting compound for cephalosporin antibiotics, represented by general formula (I), wherein X' represents an amino group that may be protecte...
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WO/1997/037997A1 |
Provided are cephem derivatives represented by the general formula: Ar-S-CH2-C-NH, wherein the substituents are herein defined. The compounds are gram-positive antibacterial agents, especially useful in the treatment of diseases caused b...
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WO/1997/037996A1 |
Cephem compounds having groups of general formula (II) at the 3-position of the cephem ring, or salts or hydrates thereof, wherein Het is a mono- or poly-cyclic hetero-ring having one or more atoms selected from among N, O and S which ma...
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WO/1997/034902A1 |
The invention discloses a purification process through ultrafiltration and/or nanofiltration with the exclusion of molecular weights higher than 10,000 Dalton and preferably higher than 2,000 Dalton. By using this technique it is possibl...
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WO/1997/033891A1 |
A process for preparing allenyl-'beta'-lactam compounds of general formula (II) or 3-halocephem compounds of general formula (III) from halogenated 'beta'-lactam compounds of general formula (I) under reaction conditions selected dependi...
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WO/1997/034027A1 |
A process for the preparation of 3-alkoxymethylcephems, characterized by electrolytically oxidizing a 3-thiomethylcephem of general formula (I) (wherein R1 is hydrogen, amino or protected amino; R2 is optionally substituted aryl; and R3 ...
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WO/1997/029111A1 |
This invention relates to new cephem compounds represented by general formula (I) wherein each symbol is as defined in the specification or a salt thereof, which has antimicrobial activity against Helicobacter pylori, and are useful as a...
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WO/1997/024359A1 |
The present invention relates to novel cephalosporin derivatives of formula (I) and pharmaceutically acceptable non-toxic salts thereof, to processes for preparing these compounds and to pharmaceutical compositions containing the same as...
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WO/1997/024358A1 |
The present invention relates to a novel crystalline cefdinir intermediate having formula (II) which can be used very usefully for preparing a cephalosporin antibiotics, cefdinir, in which Ph represents phenyl, p-TsOH represents p-toluen...
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WO/1997/022611A1 |
Novel cephem derivatives represented by general formula (I), wherein Ar is an optionally substituted lipophilic phenyl, naphthyl, benzthiazolyl or pyridyl group; R1 represents a group of formula -NR8-R9, (a) or (b) in which R8 and R9 are...
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WO/1997/022609A1 |
The present invention relates to cepham-derivatives and to a process for their preparation, having proper substituents at C-2 position, i.e. heterocyclylthio or acyloxy group. They are potent protease inhibitors, in particular human leuc...
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WO/1997/022610A1 |
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a 'beta'-lactam core is acylated, the antibiotic i...
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WO/1997/020848A1 |
The following description sets forth a reductive cyclization induced by a trialkyl phosphite of a derivative of formula (II) to give a cephalosporin of formula (I), where A is a protective group of the amino function, R1A is H, a cation ...
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WO/1997/020849A1 |
Derivatives of 7-aminoceph-3-em-2-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound each other through an ammonium salt bond, as well as the pharmaceutical compositions contai...
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WO/1997/017353A1 |
A process for the preparation of 3-halogenocephem derivatives of general formula (2), characterized by reacting an allenyl-'beta'-lactam of general formula (1) with a halogenating agent in the presence of a cuprous or cupric salt: [where...
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