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WO/2004/033464A1 |
The invention relates to a process for enrichment of the (Z)-isomer amount in a mixture of the (Z)- and (E)- isomers of 7-amino-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid.
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WO/2004/026882A1 |
The invention provides both a process for the preparation of compounds represented by the general formula (I), pharmaceutically acceptable salts thereof, or solvates of both: (I) [wherein R1 and R2 are each independently optionally subst...
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WO/2004/016623A1 |
7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetami
do]-3-vinyl-cephem-4-carboxylic acid of formula (I), in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this inventi...
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WO/2004/013097A1 |
The invention is concerned with a process for the manufacture of 3-amino-pyrrolidine derivatives of the formula (I), wherein R1 signifies hydrogen or an amino protecting group; Z signifies hydrogen or an amino protecting group; and * rep...
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WO/2004/011471A1 |
The present invention relates to a process for the preparation of cephem esters.
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WO/2004/007505A1 |
A compound of formula (IA) or of formula (IB), wherein the substituents have various meanings, useful as a pharmaceutical.
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WO/2004/000848A1 |
The present invention relates to a new process for the preparation of cephalosporin derivative of formula (I) wherein R¿1? represents p-methoxybenzyl, p-nitrobenzyl, o-chlorobenzyl or diphenylmethyl; R¿2? represents CH¿3? or CR?a¿R?b...
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WO/2004/000323A1 |
A medicinal composition for injection characterized by containing the following ingredients (A) and (B). It is useful as a highly practical injection which has high storage stability and does not become turbid upon re-dissolution. A comp...
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WO/2003/099826A1 |
The present invention provides a process for the preparation of Cefditoren of formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV), where R3 is hydrogen or trimethylsilyl with thioester deriva...
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WO/2003/093278A2 |
The present invention relates to a new method for the preparation of Ceftiofur acid of formula (I), its pharmaceutically acceptable salt such as sodium or hydrochloride and also provides two new intermediates of formulae (V) and (VI) whe...
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WO/2003/091230A1 |
The present invention provides a process for the preparation of 4−methyl−5−formyl−thiazole of the formula (I), which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using a sodi...
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WO/2003/091261A1 |
The present invention relates to a process for the preparation of cefdinir on an industrial scale.
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WO/2003/089406A1 |
The present invention relates to a process for the preparation of 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) wherein R1 represents CH3, CRaRbCOORc where Ra and Rb independently represent hydrogen or methyl and Rc rep...
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WO/2003/087105A1 |
Compounds of formula (I): wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-ß-lactamase enzymes, fo...
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WO/2003/080543A1 |
A process for producing a cyclic compound, i.e., a ß-lactam compound, represented by the following formula (3), which comprises the step of reacting a compound represented by the following formula (1) with 2 to 5 mol of a trialkyl phosp...
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WO/2003/078440A1 |
Compounds represented by the general formula (I), esters of the compounds, derivatives thereof obtained through protection of amino on the 7-position thiazole ring, or pharmaceutically acceptable salts or solvates of them: (I) wherein T ...
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WO/2003/076640A2 |
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...
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WO/2003/072582A1 |
The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition comprising the compo...
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WO/2003/064430A1 |
A crystalline hydrochloride of the compound 7-&lcub [5-amino-1,2,4-thiadiazol-3-yl-(fluoromethoxy-imino)acetyl]a
mino&rcub -3-[(imino-1-piperazinylmethyly)methylhydrazano]-methyl-3-ce
phem-4carboxylic acid and the pharmaceutical use ther...
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WO/2003/059914A1 |
The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxyli
c acid represented by formula (I) (I)by the condensation of 7-amino cephalosporanic acid (7-ACA) repre...
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WO/2003/059908A1 |
The present invention provides new thioester derivatives of thiazolyl acetic acid of general formula (I), wherein, R¿1? represents H, trityl, CH¿3?, CR¿a?R¿b?COOR¿2? (R¿a? and R¿b? independently of one another represents hydrogen ...
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WO/2003/055892A1 |
The invention relates to a process for the stabilization of an acidic aqueous phase comprising cephradine, HCl, water and residual dichloromethane in solution, wherein the aqueous phase is subjected to a vacuum distillation. The inventio...
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WO/2003/055893A1 |
The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl) thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presenc...
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WO/2003/053522A1 |
The invention described herein relates to the treatment of a range of bacterial infecions in companion animals, in particular cats and dogs, with a $(g)b-lactam derivative, compound of Fornula (1). The invention is also directed to pharm...
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WO/2003/050125A1 |
The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base. Formula (I)
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WO/2003/050124A1 |
The present invention relates to a novel crystalline cefdinir potassium dihydrate, to a process for its preparation and to a method of preparing pure cefdinir via the crystalline salt.
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WO/2003/042219A1 |
The compounds of the general formula (I) wherein R?1¿ denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R?2¿ denotes a pharmaceutically acceptable group which is ...
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WO/2003/040116A1 |
A process for the preparation of salts of organic nitrogen bases with carboxylic acids of general formula (I), wherein Q and R have the meanings defined in the disclosure, useful for the preparation of cephalosporins side chains.
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WO/2003/040148A1 |
A process for the preparation Cefixime, namely 7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]
-3-vinyl-3-cephem-4-carboxylic acid, via alkyl- or aryl- sulfonates, of general formula (IA).
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WO/2003/031451A1 |
The present invention relates to a method for preparing crystals of 7-aminocephalosporanic acid from 7-aminocephalosporanic acid solution by using additive and acid. The crystals of 7-aminocephalosporanic acid prepared according to the p...
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WO/2003/031450A1 |
The present invention relates to a process for preparing sodium salt of cephalosporins from their corresponding hydrohalide salt, which is neutralized with trimethylsilylating agent for the first time.
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WO/2003/031449A2 |
This invention provides cross-linked glycopeptide cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...
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WO/2003/024977A1 |
The present invention relates to a process for the preparation of crystalline cefuroxime axetil with high purity lecel and optimal diastereomeric ratio. Said process, which comprises the use of a dimethyl carbonate for isolating crystall...
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WO/2003/020732A2 |
The invention provides compounds of formula (I): wherein: R¿1?-R¿4? and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting $g(b)-lactamase enzymes, for enhancin...
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WO/2003/014126A1 |
A process for the preparation of highly pure cefuroxime axetil is herein described. The process makes use of a treatment, which allows removing an impurity present in the reagent l-acetoxyethyl bromide and responsible for the formation o...
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WO/2003/011871A2 |
A salt of PACA with an amidine and its use in the production of cefprozil. [6R-[6&agr ,7β(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-(
1-propenyl)-3-thia-1-azabicyclo[4.2.0]oct-2-ene-2carboxylic acid; (Formula I).
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WO/2003/010170A1 |
An improved method for synthesis of cefuroxime axetil of formula (I) in high purity substantially free of the corresponding 2-cephem($g(D)?2¿)-ester of formula (II) and other impurities. The compound produced is valuable as a prodrug es...
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WO/2003/004477A1 |
Compounds of formula (I) wherein X is halogen and R1 is alkyl or phenyl, are useful for the preparation of cephalosporins of the formula (VI) through acylation and thiourea cyclisation.
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WO/2002/098884A1 |
High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt o...
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WO/2002/096430A1 |
The invention relates to a compound and/or pharmaceutically acceptable salts, esters, hydrates or solvates thereof, having the structural formula (1) or (2): (Please insert formulas 1 and 2)wherein:- X and Y are independently selected fr...
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WO/2002/090364A1 |
The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R?1¿ is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, ...
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WO/2002/088147A1 |
A high-quality sulfate of a cephem compound (I) represented by the following formula; a solvate of the sulfate; or crystals of the sulfate or solvate. The sulfate is useful as a medicine, e.g., an injection. (I)
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WO/2002/085914A2 |
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula (III) into a 3-thiolated-$g(a)-ketoadipyl-7-aminocephalosporanic acid derivative o...
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WO/2002/086143A2 |
An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula ...
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WO/2002/085913A1 |
A penicillin and cephalosporin compound having a phenylacetic acid or phenoxyacetic acid content of 100 ppm or lower; and a process for producing a penicillin and cephalosporin compound which comprises extracting two or more times phenyl...
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WO/2002/083692A1 |
A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephemcompound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl prote...
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WO/2002/083634A2 |
The present invention relates to an improved and cost effective process for the industrial preparation of cefpodoxime acid of Formula (I) and a pharmaceutically acceptable ester thereof.
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WO/2002/070016A2 |
The invention relates to novel substituted catechol derivatives that are derived from multibase secondary amino acids and analog structures of general formula (I), wherein R<1> = H, alkyl, aryl, R<2> and R<3> = H or acyl, R<4> and R<5> =...
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WO/2002/070017A1 |
The invention relates to novel conjugates of beta-lactam antibiotics of the general formula (I) with tetra- or hexadentate iron chelators or the acylated derivatives thereof as siderophore components, derived from amino acids or peptides...
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WO/2002/068429A1 |
The present invention relates to an improved and cost effective process for the industrial manufacture of cefpodoxime proxetil. More specifically, the present invention relates to the preparation of cefpodoxime proxetil of high purity an...
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