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WO/2019/233474A1 |
The present disclosure relates to compounds with antiviral activity, methods for the preparation ofsuch compounds, and their use to inhibit viral nucleoprotein activity, viral transcription, replication, and assembly into the newly forme...
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WO/2019/229384A1 |
The invention relates to a monoethylenically unsaturated monomer of formula (I), and to the use thereof for producing a polymer. The invention also relates to the polymer obtained by polymerising said monomer, and to the use thereof in a...
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WO/2019/219468A1 |
The present invention relates to a process for preparing dioxolane by reacting ethylene glycol with an aqueous solution of formaldehyde in the presence of an acid catalyst. The raw product comprising water, dioxolane and methanol is fed ...
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WO/2019/219475A1 |
The present invention relates to a process for preparing dioxolane by reacting ethylene glycol with an aqueous solution of formaldehyde in the presence of an acid catalyst. The raw product comprising water, dioxolane and methanol is fed ...
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WO/2019/219469A1 |
The present invention relates to a compound of formula (I) wherein R1 is hydrogen or an organic radical having from 1 to 100 carbon atoms, R2, R3 independently of one another are hydrogen or an organic radical having from 1 to 100 carbon...
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WO/2019/201842A1 |
The present invention relates to a new method for the esterification of N-acylated amino acids containing an acid-labile ketone protective group under alkaline conditions without the use of a polar aprotic solvent, by esterifying the N-a...
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WO/2019/197231A1 |
The present invention relates to new methods for producing cis-alkoxy substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and new intermediates or starting compounds that are used in the method according to the invention.
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WO/2019/185877A1 |
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diast...
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WO/2019/175713A1 |
The present invention relates to the new catechol molecules and their use as inhibitors to P450 related metabolic pathways. The invention further relates to a method of controlling crop pests and/ or non-crop pests that are resistant to ...
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WO/2019/175712A1 |
The present invention relates to a use of compounds of the formula (I) as Glutathione-S-transferase inhibitor. The invention further relates to a method of controlling crop pests and/or non-crop pests that are resistant to one or more in...
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WO/2019/172184A1 |
Provided is a metal imide complex which has a stable structure and is able to be easily synthesized, while being capable of efficiently oxidizing various substrates. A metal imide complex which contains a metal and an imide that serves a...
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WO/2019/173772A1 |
The present disclosure is directed to l-(2-hydroxy-4-methylcyclohexyl)-ethanone derivatives having unique and desired flavor and/or fragrance characteristics, as well as the synthesis and application of the derivatives. The compounds of ...
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WO/2019/173776A1 |
The present disclosure is directed to 1-(4-methyl cyclohex-1-en-1-yl)ethan-1-one derivatives having unique and desired flavor and/or fragrance characteristics, as well as the synthesis and application of the derivatives. The compounds of...
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WO/2019/165636A1 |
Provided is a preparation method for a fluorine-containing 1,3-dioxocycloalkane olefin, comprising: first, reacting a compound of formula (I) with a compound of formula (II) to obtain a compound of formula (III); and then further reactin...
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WO/2019/159596A1 |
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...
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WO/2019/156228A1 |
Provided are: a 2-cyanoacrylate compound which is represented by formula (1); and an adhesive composition which contains this 2-cyanoacrylate compound represented by formula (1). In formula (1), L1 represents a divalent linking group hav...
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WO/2019/151267A1 |
The present invention relates to a method for producing a 1,3-dioxolane compound represented by formula 1, the method comprising step (a), in which hexafluoroacetone monohydrate is brought into contact with a metal fluoride, step (b), in...
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WO/2019/148244A1 |
The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).
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WO/2019/141881A1 |
The compound (3aS,4a R,5S,7a S,9R,9aR)-2,2,5,8,8,9a-hexamethyloctahydro-4H-4a,9- methanoazuleno[5,6-d][1,3]dioxole, compositions and consumer products comprising the compound, methods of making the compound, and the various uses of the c...
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WO/2019/128113A1 |
The present invention provides a 1-O-caffeoylquinic acid derivative represented by formula (II), a 1-O-caffeoylquinic acid, and applications of the 1-O-caffeoylquinic acid derivative represented by formula (II) and salts thereof. The 1-O...
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WO/2019/124092A1 |
The present invention provides: a compound represented by formula (i), a liquid crystal composition using said compound, and a liquid crystal display device using said liquid crystal composition. The compound represented by formula (i) h...
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WO/2019/125151A1 |
Process to continuously prepare a cyclic carbonate product by reacting an epoxide compound with carbon dioxide in the presence of a supported dimeric aluminium salen complex which complex is activated by a halide compound comprising the ...
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WO/2019/115399A1 |
The invention relates to a process for producing glycerol carbonate methacrylate, in which glycidyl methacrylate is reacted with carbon dioxide in the presence of a catalyst and a solvent, characterized in that the catalyst is potassium ...
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WO/2019/115781A1 |
The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit t...
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WO/2019/110734A1 |
The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention fu...
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WO/2019/113523A1 |
The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, diseases associated wi...
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WO/2019/110716A1 |
The invention relates to a process for producing ethylene glycol and/or ethylene carbonate, said process comprising contacting at least a portion of a recycle gas stream comprising an alkyl iodide impurity with a guard bed system positio...
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WO/2019/110713A1 |
The present application relates to a process for producing ethylene glycol and/or ethylene carbonate, said process comprising contacting at least a portion of a recycle gas stream comprising an alkyl iodide impurity with a guard bed syst...
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WO/2019/105193A1 |
A factory, power plant, or refinery flue gas capture, conversion, and application total recycling system. A combined decontamination and dust removal unit removes dust and oxides; a capture subsystem captures CO2; a water recovery unit r...
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WO/2019/104841A1 |
The purpose of the present invention is to provide a method for preparing a cyclic carbonate, which has the advantages of a high yield and mild reaction conditions, while having high catalytic efficiency under normal temperature and pres...
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WO/2019/106029A1 |
The present invention relates to norbornadiene compounds (Formula I), and the corresponding quadricyclane compounds (Formula III). The compounds are to be included in a molecular thermal systems (MOST), and to be used for storing solar e...
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WO/2019/106000A1 |
The present invention concerns compound of formula (I) in the form of any one of its stereoisomers or as a mixture thereof, and wherein Q group represents a —CH=CH—CH3 group or a —C≡C—CH3 group. The use as a perfuming ingredien...
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WO/2019/108046A1 |
The present invention provides a use of a 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative for protecting pancreatic beta cells. A 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative according to the present invention resolves a side ef...
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WO/2019/104030A1 |
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.
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WO/2019/090069A1 |
Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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WO/2019/090076A1 |
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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WO/2019/080686A1 |
Disclosed are an entecavir intermediate, a preparation method for the intermediate and a method for preparing entecavir using the intermediate. The synthesis methods for entecavir and the intermediate thereof in the present invention hav...
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WO/2019/079119A1 |
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: wherein the variables shown in Formula AA can be as defined anywhere herein. Compounds AA are modulators of NLRP1 and/or NLRP3
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WO/2019/073775A1 |
The present invention provides a method for producing a cyclic carbonate having an unsaturated group in a simple manner. A method for producing a cyclic carbonate represented by formula (1) (wherein X1 and X2 are the same as or different...
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WO/2019/073491A1 |
The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities.
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WO/2019/067543A1 |
The present disclosure relates to compounds that are capable penetrating to the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating Glioblastoma and other EGFR media...
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WO/2019/063952A1 |
The invention relates to a new method for the synthesis of unsymmetrical tertiary amines using alcohol and an imine, and to new tertiary amines.
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WO/2019/058890A1 |
The present invention provides an active light sensitive or radiation sensitive resin composition which has an excellent LER. Furthermore, provided are: a resist film; a method for forming a pattern; and a method for manufacturing an ele...
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WO/2019/059344A1 |
The present invention addresses the problem of providing a novel chemically activated water-soluble prodrug. The present invention provides a compound represented by formula (1), or a pharmacologically acceptable salt thereof (in the for...
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WO/2019/049795A1 |
The purpose of the invention is to provide: a composition capable of forming a film exhibiting excellent flatness, wet peeling resistance, and pattern bending resistance while maintaining solvent resistance; a film; a method for forming ...
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WO/2019/043587A2 |
The present invention relates to a process for the preparation of Treosulfan using sodium borohydride and iodine as reducing agent, which is less hazardous and convenient as compared to the reagents used in the prior art. The invention a...
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WO/2019/037860A1 |
Compounds of formula (I) wherein A, R, W, Q, L, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
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WO/2019/034716A1 |
Process for producing esters of (meth)acrylic acid or a derivative thereof by reaction of (meth)acrylic acid or a derivative thereof with glycerol carbonate in the presence of at least one enzyme which catalyzes the esterification reacti...
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WO/2019/034648A1 |
The present invention relates to a process for preparing cyclic carbonates of formula Ia or Ib or mixtures thereof (Ia) (Ib) comprising the process step: a) reacting a propargylic alcohol of formula II (II) with carbon dioxide in the pre...
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WO/2019/024635A1 |
Provided are a 1,3-di-substituted ketene compound having a structure as represented by formula (I) and an application thereof. Such a type of compound primarily activates peroxisome proliferator-activated receptor (PPAR) α, and also act...
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