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WO/2017/046816A2 |
The present invention relates to the process for preparing compounds of Formula I, Formula III and Formula V.
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WO/2017/040778A1 |
The invention provides compounds of Formula XXIII: (Formula XXIII) wherein R1 is hydrogen, alkyl, acyl, or silyl, R2 is hydrogen, alkyl, benzyl, acyl, or ester, and R3 is hydrogen, alkyl, an aromatic group, azacyclic, carbocycle, aryl, c...
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WO/2017/027388A1 |
Disclosed herein are the conversion of estolide compounds having unsaturated fatty acid groups into estolides containing cyclic carbonate moieties and methods of making and using the same. The estolides containing a cyclic carbonate may ...
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WO/2017/017696A1 |
The present disclosure relates to processes for the preparation of lumacaftor useful for treating a cystic fibrosis transmembrane conductance regulator (CFTR)-mediated disease such as cystic fibrosis. The present disclosure also provides...
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WO/2017/017210A1 |
The present invention concerns methods for the manufacture of ethylene carbonate substituted with a fluorinated alkoxy group, certain ethylene carbonates substituted with a fluorinated alkoxy group as well as their use as solvent or solv...
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WO/2017/009860A1 |
The anticancer activity of gallic acid compounds has been invented, in order to obtain new potent and cost effective molecule using in vitro cytotoxicity assay. The invention particularly relates to the gallic acid based new molecules i....
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WO/2017/009804A1 |
The present invention provides for compounds of formula (I) wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases a...
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WO/2016/202652A1 |
The invention relates to copolymers made from (a) at least one monomer M1 of formula (I), where R1 stands for an organic group comprising a (meth)acryl group, R2, R3 and R4 stand, independently from one another, for a hydrogen atom or a ...
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WO/2016/199906A1 |
The purpose of the present invention is to provide a novel low-molecular-weight compound which exhibits orexin receptor agonist activity and is expected to be useful as a prophylactic agent or therapeutic agent for narcolepsy and the lik...
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WO/2016/197439A1 |
An imidazole ionic liquid-ZnX2/base catalytic system and a method for catalytic preparation of an ethylene carbonate derivative with same. The catalytic system is composed of three ingredients, an imidazole ionic liquid, ZnX2 and a base ...
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WO/2016/198374A1 |
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...
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WO/2016/201214A1 |
The present invention relates to compounds which have been discovered to be potent ligands (inhibitors) of human GLUT5 (glucose transporter type 5), a facilitative glucose transporter that transports fructose, and their use as ligands as...
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WO/2016/191872A1 |
Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also...
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WO/2016/196346A1 |
Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compound...
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WO/2016/192631A1 |
The present invention provides an abietane-type diterpene compound having lipid-lowering activity, a method for preparing same, and use of same. Specifically, the compound has the structure shown in formula I. The definitions of the grou...
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WO/2016/188875A1 |
The present invention relates to a method for synthesizing cyclocarbonates by reacting an epoxy compound and carbon dioxide at atmospheric pressure and elevated temperature in the presence of a heterogeneous catalyst system comprising an...
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WO/2016/185392A1 |
The present invention relates to a process for preparing aliphatic aldehydes starting from 1,2-diols. Said aldehydes can be advantageously used for the synthesis of fuel components. In particular, the present invention relates to a proce...
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WO/2016/181894A1 |
The present invention provides a compound which has an excellent TLR4 signaling inhibitory effect and is useful as a prophylactic or therapeutic agent for diseases such as autoimmune diseases and/or inflammatory diseases, chemotherapy-in...
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WO/2016/182036A1 |
The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemot...
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WO/2016/172425A1 |
Compounds of Formulas I-VI, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth. Formula I is exemplified below: Formula (i)
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WO/2016/172496A1 |
Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions ...
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WO/2016/172191A1 |
Compounds that inhibit CNKSR1, pharmaceutical compositions including compounds that inhibit CNKSR1 and methods of treating disease or disorders that respond to CNKSR1 inhibition are described herein. Additionally, methods of identifying ...
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WO/2016/169858A1 |
The invention relates to compounds of formula (I) wherein R1 represents an organic group having a (meth)acrylic group, and R2, R3 and R4 independently of one another represent an H atom or a C1 to C10 alkyl group.
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WO/2016/162627A1 |
The invention relates to a hydrocarbon polymer comprising two exo-vinylene cyclic carbonate terminal groups, of formula (1), production method thereof and use of same for the production of coating, mastic and adhesive compositions.
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WO/2016/162389A1 |
The present invention relates to novel compounds which are useful as functionalized photoinitiators which may be used directly or after further functionalization in various photo-curable coating compositions, including varnishes, lacquer...
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WO/2016/161286A1 |
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, suc...
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WO/2016/155888A1 |
The present invention relates to novel compounds of the formula I, methods for their preparation and their use for treatment of diseases. The invention discloses the synthesis of levodopa (L-DOPA) esters by coupling polyhydroxy compounds...
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WO/2016/161269A1 |
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...
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WO/2016/153011A1 |
The purpose of the present invention is to provide a cooling agent composition containing a novel methyl menthol derivative having no undesirable feeling of stimulation, malodor, bitterness, or the like, it being possible to use the cool...
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WO/2016/153432A1 |
The present invention relates to substituted phenyl cinnamyl ketones of Formula (I) for use in therapy: wherein R1 to R11 are defined as described in the specification, or a pharmaceutically acceptable salt, tautomer(s), solvate or polym...
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WO/2016/149099A1 |
The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
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WO/2016/147133A1 |
The present invention provides a novel process for the preparation of droxidopa, a synthetic amino acid precursor of norepinephrine. The process is a stereoselective process for the preparation of droxidopa using asymmetric induction and...
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WO/2016/141889A1 |
Provided are a novel triazolopyrimidine derivative represented by formula II, crystal form and preparation method thereof, and use thereof in the preparation of medicine for resisting coagulation and thrombus, treating or preventing cere...
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WO/2016/131098A1 |
ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in ...
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WO/2016/133073A1 |
Provided is a compound which has a Hammett substituent constant σ of -0.05 or lower and which is represented by general formula (1). (1) (In formula (1): Ar1 and Ar2 each independently represent an optionally substituted phenylene group...
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WO/2016/133160A1 |
The purpose of the present invention is to provide a novel low molecular weight compound that exhibits orexin receptor agonist activity and is expected to be useful as an excellent preventative or therapeutic agent for narcolepsy or the ...
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WO/2016/132355A1 |
Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes ...
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WO/2016/123707A1 |
The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in par...
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WO/2016/114722A1 |
The present invention relates to a composition represented by structural formula (A) [Formula should be entered here] or a salt thereof, as well as a method of visualizing a target cell, the method including (a) contacting a population o...
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WO/2016/109501A1 |
The present invention is directed to amide compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment or prevention of diseases or disorders associated with peripheral ...
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WO/2016/103058A1 |
The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as en...
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WO/2016/102706A1 |
The invention relates to a compound of general formula (I) (in configuration Z or E) and to pro-pheromonal compositions and formulations comprising said compound, in addition to the uses thereof for soothing purposes for non-human mammal...
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WO/2016/101898A1 |
The present invention relates to 3-[(benzo[d][1,3]dioxolane-4-yl)-oxy]-3-arylaniline type compounds of Formula I or pharmaceutical acceptable salts thereof and applications thereof. The compound may be used to prepare antidepressants.
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WO/2016/104332A1 |
[Problem] To provide a method for producing 3-methylglutaraldehyde with a good yield under mild conditions, and a novel acetal compound that is useful for implementing this method. [Solution] Provided is a method for producing 3-methylgl...
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WO/2016/079759A9 |
The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, effic...
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WO/2016/096905A1 |
This invention concerns the first mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalystand amine donor. The initial heterogeneous metal- catalyzed reaction between the ca...
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WO/2016/096540A1 |
The invention relates to special orthoformic acid esters of formula (I), as defined herein, which can be used as thermally labile and acid-labile pro-fragrances. The invention further relates to detergents and cleaning agents, cosmetic a...
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WO/2016/097840A1 |
The invention relates to a novel product and more specifically a glycerol acetal or glycerol ketal ether-ester, to the methods for the production thereof, and to the use of same as a solvent, co-solvent, plasticiser, coalescing agent, su...
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WO/2016/097569A1 |
The invention relates to novel fragrant compounds having animalic or ambergris notes, without any woody characteristic. More specifically, the invention relates to novel acetal derivatives of 1-(3,3-dimethylcyclohex-1-enyl) ethanone of g...
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WO/2016/092546A1 |
Methods and compositions utilizing 2-aminoindan derivatives collectively represented by Formula I as described and defined in the specification for regulating binge behavior, particularly binge drinking, are disclosed.
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