Heterocyclic Compounds

Matches 151 - 200 out of 436	< 1 2 3 4 5 6 7 8 9 >

Document	Document Title
WO/2000/071118A1	PHOSPHOLIPASE A¿2?-SPECIFIC INHIBITING COMPOUNDS The invention concerns novel phospholipase A¿2? specific inhibiting compounds of general formula (I). Said novel compounds are capable of acting on PLA¿2? and are advantageously PLA¿2?snp-specific inhibiting compounds completely inact...
WO/2000/069862A2	HEMISYNTHETIC METHOD AND INTERMEDIATES THEREOF Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically: R?1¿ is an amidomethylene group or an a...
WO/2000/063195A1	NOVEL HETEROCYCLIC AMINO CARBONYL DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The current invention discloses novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors
WO/2000/042029A1	1-HETEROCYCLE SUBSTITUTED DIARYLAMINES 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
WO/2000/039109A1	METHOD FOR PRODUCING 6-METHYL-3,4-DIHYDRO-1,2,3-OXATHIAZIN-4-ONE-2,2-DIOXIDE FROM 5-CHLORO-6-METHYL-3,4-DIHYDRO-1,2,3-OXATHIAZIN-4-ONE-2,2-DIOXIDE The invention relates to a method for producing 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide by reacting 5-chloro-6-methyl-3,4 dihydro-1,2,3-oxathiazin-4-one-2,2 dioxide with hydrogen in the presence of a base and a catalyst, ...
WO/2000/031036A1	NOVEL NAPHTHALENE DERIVATIVES Novel naphthalene derivatives represented by general formula (1), which exhibit an excellent fibrinolysis accelerating effect and are useful as orally administrable antithrombotic or thrombolytic agents.
WO/2000/027795A1	TRANSFECTION REAGENTS Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having general structure (A).
WO/2000/012084A1	GEOMETRICALLY RESTRICTED 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
WO/2000/010969A1	SULFONYLIMIDES AND THEIR USE AS CONDUCTIVE SALTS Novel sulfonylimide and sulfonylmethide compounds are described which are useful as conductive salts. Also described is the use of the above compounds in salt form in battery electrolytes, particular salts having mixed perfluorocarbon an...
WO1999058500B1	METHOD FOR STEREOCHEMICALLY CONTROLLED PRODUCTION OF ISOMERICALLY PURE HIGHLY SUBSTITUTED AZACYCLIC COMPOUNDS The invention relates to a method for stereochemically controlled production of azacyclic compounds of general formula (I), whereby the substituents have the meaning cited in the description. The invention also relates to intermediate pr...
WO/1999/057116A2	PESTICIDAL METHOXIMINOMETHYLOXATHIAZINES The invention relates to novel methoximinomethyloxathiazines of formula (I), to two methods for producing them and to their use as pesticides.
WO/1999/031074A2	((CYCLO)ALKYL SUBSTITUTED)-.GAMMA.-AMINOBUTYRIC ACID DERIVATIVES (=GABA ANALOGUES), THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS Novel amines of formulas (1A) and (1B) or a pharmaceutically acceptable salt thereof wherein: n is an integer of from 0 to 2; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; A is hydrogen or meth...
WO/1999/031075A1	1-SUBSTITUTED-1-AMINOMETHYL-CYCLOALKANE DERIVATIVES (=GABAPENTIN ANALOGUES), THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic a...
WO/1999/025701A1	NOVEL HETEROCYCLICALLY SUBSTITUTED $g(a)-HYDROXYCARBOXLIC ACID DERIVATIVES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS The invention relates to carboxylic acid derivatives of formula (I) wherein A represents NR?8¿R?9¿, azido, OR?10¿, SR?10¿ or C¿1?-C¿4? alkyl, R?1¿ represents tetrazole or a group (1), wherein R has the following meaning: a) a radi...
WO/1999/005131A1	1,3-DIAZA- HETEROCYCLES AND THEIR USE AS NITRIC OXIDE SYNTHASE INHIBITORS Compounds of formula (I) are useful as nitric oxide synthase inhibitors.
WO/1998/051665A2	NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS This invention relates to macrocyclic molecules of formula (I) which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). The present invention also relates to pharmaceutical compositions ...
WO/1998/039006A1	TROGLITAZONE COMPOUNDS FOR TREATING CLIMACTERIC The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel discovery that Troglitazone inhibits steroid...
WO/1998/034929A1	IL-8 RECEPTOR ANTAGONISTS The invention relates to certain 8-ureido and 8-thioureido 1,2-benzothiazines, 1,2,4-benzothioxazines and 1,2,4-benzothiodiazines useful in the treatment of disease states mediated by the chemokine, Interleukin-8.
WO/1998/031682A1	4-(3-HETEROCYCLYL-1-BENZOYL)PYRAZOLES AND THEIR USE AS HERBICIDES, The invention concerns 4-(3-heterocyclyl-1-benzoyl)pyrazoles of formula (I) in which the variables have the following meanings: R?1�, R?3�: hydrogen, nitro, halogen, cyano, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkyl...
WO/1998/031681A1	3-HETEROCYCLYL-SUBSTITUTED BENZOYL DERIVATIVES, The invention concerns benzoyl derivatives of formula (I) in which the variables have the following meanings: R?1�, R?2�: hydrogen, nitro, halogen, cyano, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkylthio halide, alkyl...
WO/1998/025598A2	METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING TUMOUR CELL GROWTH Methods for inhibiting proliferation of a PPAR$g(g)-responsive hyperproliferative cell using PPAR$g(g) agonists are described. Pharmaceutical compositions as well as methods for diagnosing and treating a PPAR$g(g)-responsive hyperprolife...
WO/1998/023601A1	PROCESS FOR PREPARING N-ALKYL AMMONIUM ACETONITRILE COMPOUNDS A process for the preparation of a compound having the structure of Formula (I) wherein A, R�1?, R�2?, R�3?, Y and Z are as defined in the disclosure. The process includes reacting a heterocyclic amine with a monoaldehyde or a dial...
WO/1998/017653A1	OXIME DERIVATIVES AND THEIR USE AS FUNGICIDES, The invention relates to novel oxime derivatives of formula (I) , in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (i...
WO/1998/009955A1	PROCESS AND NOVEL INTERMEDIATES This invention provides intermediates and processes useful for the preparation of crytophycin compounds.
WO/1998/008505A1	PHARMACEUTICAL COMPOUNDS The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...
WO/1997/042185A1	1,2-BENZOXATHIIN AND THIEPIN 2,2-DIOXIDE HERBICIDES Compounds of formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation. In said formula (I) Q is (Q-1), (Q-2) or (Q-3); and A, R1-R7, and q are as defined in th...
WO/1997/041199A1	SULFANIMINES AS BLEACH CATALYSTS Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are sulfanimines. Substrates such as fabrics may be bleached in an aqueous solution containing ...
WO/1997/030038A1	DIARYLSULTAM DERIVATIVES Compounds represented by the following general formula: A-C(X)(Y)-C(R1)(R2)-Z wherein Z represents, for example, -N(R3)-(CH2)p-B [wherein R3 represents alkyl, etc.; p is an integer of from 3 to 8; and B represents a group represented by ...
WO/1997/018207A2	NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
WO/1996/033984A1	N-SULFOXY ANHYDRIDES, A PROCESS FOR THE PREPARATION THEREOF AND ITS USE FOR THE PREPARATION OF BIOACTIVE SUBSTANCES HAVING ACE INHIBITORY ACTION Novel N-sulfoxy anhydrides, a process for the preparation thereof and its use for the preparation of bioactive substances having ACE inhibitory action. Novel compounds of formula (III), wherein R1 represents PhCH2-CH2- or CH3CH2-CH2- and...
WO/1996/025406A1	FUNGICIDAL AZA-HETEROCYCLOALKENES Compounds of formula (I) in which A is possibly substituted alkylene, Ar is possibly substituted arylene or heteroarylene, E is preferably one of the grouping (a), (b), (c), (d), (e), Y1 is oxygen, sulphur or a possibly alkyl-substituted...
WO/1996/017835A1	FUNGICIDAL 1,3,4-OXATHIAZOL-2-ONES The invention pertains to novel oxathiazolinones of formula (I), a method for preparing them and their use as fungicides.
WO/1996/016950A1	HIV PROTEASE INHIBITORS A HIV-1 protease inhibitor which includes an N-terminal cycle (A) or a C-terminal cycle (B) or both cycles (A) and (B) wherein Y is selected from side chains of Asn or Ile or Val or Glu and alkyl of 1-6 carbon atoms inclusive of linear o...
WO/1995/025104A1	NOVEL HETEROCYCLIC ETHANOLAMINE DERIVATIVES WITH BETA-ADRENORECEPTOR AGONISTIC ACTIVITY A compound of the formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein, X represents a moiety of formula (a), in which A1 represents -CH=CH=, NH, S or O; A2 represents an o...
WO/1995/022082A1	COLOUR-PHOTOGRAPHIC RECORDING MATERIAL The invention relates to a colour-photographic recording material which comprises a magenta coupler and, as stabilizer, at least one compound of formula (Ia), (Ib) or (II), where the radicals are as defined in claim 1, and to the novel s...
WO/1995/007697A2	USE OF THIAZOLIDINEDIONE DERIVATIVES AND RELATED ANTIHYPERGLYCEMIC AGENTS IN THE TREATMENT OF DISEASE STATES AT RISK FOR PROGRESSING TO NONINSULIN-DEPENDENT DIABETES MELLITUS Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations at risk for developing noninsulin-dependent diabetes mellitus (NIDDM) and complications arising therefrom are disclosed. In one e...
WO/1995/007694A1	USE OF THIAZOLIDINEDIONES TO PREVENT OR DELAY ONSET OF NIDDM Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations experiencing impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus (NIDDM) ...
WO/1995/005739A1	ANTIBACTERIAL AND ANTIFOULING OXATHIAZINES AND THEIR OXIDES Use of 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides having formula (I), wherein n is 0, 1 or 2; R1 is hydrogen, C1-4alkyl or benzyl; and R represents (a) phenyl; phenyl substituted with 1 to 3 substituents independently selecte...
WO/1995/006043A1	WOOD PRESERVATIVE OXATHIAZINES The present invention provides certain 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides, useful for the long-term preservation of wood and composite wood materials against wood damaging and wood destroying materials. The present in...
WO/1995/001979A1	NOVEL (1-HETEROAZOLYL-1-HETEROCYCLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS The present invention relates to novel heterocyclic compounds having general formula (1) wherein: X is O, S, Se, or NR2; Y1, Y2, Y3, Y4 independently are N or CR2; Z is O, S, Se, NR2 or C = N; and A is (a) or (b) wherein W is O, S, NH or...
WO/1994/002483A1	TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS The present invention relates to heterocyclic compounds of formula (I), which have been found to have anti-tumour activity. More specifically, the invention concerns Pyrrolo [3,2-b_] carbazoles, 1H-Benzofuro [3,2-f_] indoles and 1H-[1] B...
WO/1993/019055A1	PROCESS AND DEVICE FOR PREPARING THE NON-TOXIC SALTS OF 6-METHYL-3,4-DIHYDRO-1,2,3-OXATHIAZIN-4-ON-2,2-DIOXIDE According to a process for preparing acesulfam salts by reacting amidosulfonic acid salts with diketen, yielding an acetoacetamidosulfonic acid salt (I), ring closure is effected under the influence of an at least equivalent amount of SO...
WO/1993/004071A1	BENZOTHIAZOLONE Benzothiazolone derivatives of formula (I), wherein Y is oxygen or sulfur; R¿1? is hydrogen or fluorine; and R¿2? is hydrogen, C¿1?-C¿6?alkyl, C¿2?-C¿4?alkenyl, or C¿2?-C¿6?alkynyl; halo-substituted C¿1?-C¿6?alkyl, C¿2?-C¿4?a...
WO/1993/004142A1	STABILIZED COMPLEX LIGANDS AND THEIR USE IN LIQUID CRYSTAL DISPLAYS Decomposable complex ligands may be stabilized by derivating them with blocking secondary or tertiary carbonic or sulfonic acids. Orientation layers and liquid crystal mixtures may be added to these stabilized derivates that cause in FLC...
WO/1992/020669A1	PROCESSES FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
WO/1992/020696A1	PROCESSES FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
WO/1992/020662A1	ACIDIC ARALKYL TRIAZOLE DERIVATIVES ACTIVE AS ANGIOTENSIN II ANTAGONISTS Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of formula (I) are useful as angiotensin II antagonists.
WO/1992/018490A1	NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME Bicyclic derivatives of general formula (I), wherein X1 is -S- or -SO-; X2 is -CO- or -CS-; R1 is hydrogen, halogen or lower alkyl optionally substituted by halogen or lower alkoxy; R2 and R3 are each independently hydrogen, lower alkyl,...
WO/1992/005164A1	NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.
WO/1992/000967A1	BISHETEROCYCLIC COMPOUND A novel bisheterocyclic compound represented by general formula (I), which is useful as a hypoglycemic drug, and a novel hypoglycemic drug containing the same, wherein R?1¿ and R?2¿ are the same or different from each other and each re...

Matches 151 - 200 out of 436	< 1 2 3 4 5 6 7 8 9 >