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WO/1997/021692A1 |
This invention provides novel thiomorpholinone compounds useful for treating multiple sclerosis.
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WO/1997/020824A1 |
The invention relates to compounds of formula (1) wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms other than C* and N independently is unsubstit...
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WO/1997/014693A1 |
Compounds of general formula (I), in which R1 is C(CO2CH3)=CHOCH3, C(CO2CH3)=NOCH3, N(OCH3)CO2CH3 and C(CONHCH3)=NOCH3; R2 is cyano, halogen, C1-C4 alkyl and C1-C4 alkoxy; m is 0 or 1; R3 is cyano, halogen, C1-C4 alkyl, C1-C4 alkyl halid...
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WO/1997/009324A1 |
Benzoyl derivatives according to formula (I), where substituents L, M, X, Y and n have the meaning given in claim 1 and Q stands for a 2-position cross-linked cyclohexane-1,3-dione ring according to formula (II), where R15, R16, R18, and...
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WO/1997/008164A1 |
Compounds of Formula (I), and their agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetaion, wherein Q is (Q-1) or (Q-2); and A, Y, Z, R1-R7, q and r are as defined in the disclosure. Also disclo...
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WO/1997/003054A1 |
The invention provides compounds of formula (I) wherein X, Y, R1, R2, R3 and R4 are as defined in the description, and a process for preparing them. The compounds of formula (I) are useful as pharmaceuticals.
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WO/1997/002243A1 |
The invention concerns novel compounds of formula (I) in which: X stands for alkyl; Y stands for halogen or alkyl; Z stands for halogen or alkyl, a condition being that one of the groups Y and Z always stands for halogen and the other fo...
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WO/1997/001546A1 |
The invention pertains to new 1,3-oxa(thia)zine derivatives of formula (I), wherein A is substituted phenyl or in each case substituted naphthyl, pyridyl, thienyl, phenylalkyl or phenylalkenyl; D is hydrogen, alkyl, alkyl halide, alkoxya...
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WO/1997/001535A1 |
The invention concerns novel phenyl-substituted cyclic keto-enols of formula (I) in which Het stands for one of the groups shown in which A, B, D, G, X, Y and Z have the meanings indicated in the description. Also disclosed are several p...
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WO/1997/000853A1 |
Compounds of general formula (I), salts thereof or hydrates thereof wherein (a) represents (b) or (c), for example, the compounds (d) and (e), which are useful as a PGD2 antagonist and thus usable in, for example, a remedy for systemic m...
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WO/1996/040672A1 |
Combinatorial libraries are constructed to include aminodiol monomer subunits connected by phosphodiester, phosphorothioate, or phosphoramidate linking moieties. Combinatorial libraries of the invention feature a plurality of functional ...
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WO/1996/038446A1 |
Novel fused polycyclic heterocycle derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which have an excellent antitumor effect, and a process for producing the same, wherein the ring A represents...
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WO/1996/035664A1 |
New compounds have the formula (I), in which X stands for halogen, Y stands for halogen or alkyl and Z stands for halogen or alkyl, provided that one of the residues Y and Z always stands for halogen and the other for alkyl, and Het stan...
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WO/1996/034846A1 |
Compounds of 1,3-propane diol linked structure (I), when for use in therapy, where R1 is an acyl or fatty alcohol group derived from a C12-30 preferably C16-30 fatty acid desirably with two or more cis or trans double bonds, and R2 is hy...
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WO/1996/034855A1 |
Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or colu...
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WO/1996/034858A1 |
Niacin as a compound, per se or for use in therapy, of structure (I), where B is -C(=O)- (nicotinic acid) or -CH2-O- (niacin alcohol), the "link" C which is optional is a diol or hydroxy carboxylic acid or dicarboxylic acid residue, and ...
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WO/1996/033172A1 |
A compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal ...
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WO/1996/030766A1 |
The present invention relates to novel methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association and pathological neurofilament aggregation. The methods of the present invention ...
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WO/1996/026200A1 |
The invention concerns benzoyl derivatives of formula (I) in which the substituents have the following meanings: L and M represent hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, C1-C4 alkoxy (these groups being optionally substitut...
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WO/1996/026195A1 |
Novel benzothiazine dioxides which are antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation, and pharmaceutical compositions of the same, which are useful in treat...
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WO/1996/026193A1 |
Phenyldiketone derivatives have the formula (I), in which the substituents have the following meanings: L, M are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, C1-C4 alkoxy optionally substituted by 1 to 5 halogen atoms or C1-C4 al...
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WO/1996/024690A1 |
Biomolecule analysis using anodic oxidation of aqueous sodium 9, 10-diphenylanthracene-2-sulfonate (DPAS) and 1- and 2-thianthrenecarboxylic acid (1-THCOOH and 2-THCOOH) in the presence of tri-n- propylamine (TPrA) as a coreactant in aqu...
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WO/1996/022286A2 |
Compounds of formula (I), and their N-oxides and agriculturally-suitable salts, are disclosed which are useful as arthropodicides wherein: A is selected from the group direct bond, C1-C3 alkylene and C2-C4 alkenylene; Q is selected from ...
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WO/1996/015791A2 |
Disclosed are compounds of formula (I), wherein X is selected from oxygen, sulfur and NR; wherein R is selected from hydrogen, lower alkyl and CH2CH2COAr1; and Z is hydrogen; straight or branched chain alkyl having 1-6 carbon atoms; or Z...
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WO/1996/014842A1 |
Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, di...
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WO/1996/014844A1 |
Disclosed herein are the heterocyclic compounds and pharmaceutically acceptable salts thereof which have been found to be useful in the treatment of nitric oxide synthase mediated diseases and disorders.
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WO/1996/011183A1 |
The present invention relates to oxime ethers of general formula (I) and to their isomers and isomer mixtures which are possible in which (a) X is an N atom and Y is an oxygen atom or NH, or (b) X is CH and Y is an oxygen atom, in which ...
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WO/1996/007648A1 |
This invention concerns certain 2-substituted-3,1-benzoxazin-4-ones and benzthiazinones as complement Clr protease inhibitors and anti-inflammatory agents, pharmaceutical compositions containing them, methods of using them, and processes...
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WO/1996/006076A1 |
A compound represented by general formula (I) or a medicinally acceptable salt thereof, (wherein R1 represents hydrogen, C1-C6 alkoxycarbonyl or C1-C9 acyl; R2 represents hydrogen or C1-C6 alkyl; R3 represents C1-C6 alkyl or C2-C6 alkeny...
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WO/1996/006072A1 |
Compounds of formula (I) are suitable for controlling and preventing infestation by micro-organisms, insects and acarina on plants and their possible isomers and mixtures of isomers, wherein (a) X is CH2F or CHF2, Y is CH and Z is OCH3, ...
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WO/1996/005837A1 |
The invention concerns the use of N-substituted phenothiazines for producing drugs for treating cerebral disorders. The invention also concerns novel active substances prepared by reacting phenothiazine with the appropriate acids, esters...
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WO/1996/005185A1 |
The present invention relates to novel alkylamino derivatives of formula (I). These compounds exhibit a high selectivity and a high affinity for sigma 2 receptor and therefore are useful in the treatment of central nervous system disorde...
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WO/1996/003406A1 |
Compounds of formula (I), which are in equilibrium with their 4-hydroxy tautomers and are in the form of diastereomeric mixtures, and their pharmaceutically acceptable salts are potent GARFT inhibitors. A is S, CH2 or Se; Z is a substitu...
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WO/1996/003407A1 |
The invention relates to compounds, such as compound (1) in equilibrium with its 4-hydroxy tautomer, and its pharmaceutically acceptable salts. Such compounds are useful as inhibitors of glycinamide ribonucleotide formyl transferase (GAR...
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WO/1996/000378A1 |
Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporatinf these linking groups and methods for their use are also described.
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WO/1996/000148A1 |
This invention provides an efficient and versatile method for the combinatorial synthesis and screening of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivat...
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WO/1995/033723A1 |
Compounds of formula (I), in which W is -(CH2)4, (CH2)5, -(CH2)2O(CH2)2 or -(CH2)2S(CH2)2 n is 0 to 6; m is 0 to 3; A is a bond, -CH=CH-, -CC-, oxygen, sulphur or NR1; R1 is hydrogen, C1-8alkyl or phenyl C1-4alkyl; and Ar is a group (a) ...
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WO/1995/033722A1 |
Compounds of formula (I) in which W is -(CH2)4, (CH2)5, -(CH2)2O(CH2)2 or -(CH2)2S(CH2)2, n is 0 to 6; m is 0 to 3; A is a bond, -CH=CH-, -CC-, oxygen, sulphur or NR1; R1 is hydrogen, C1-8alkyl or phenylC1-4alkyl; and Ar is a group (a) w...
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WO/1995/033717A2 |
New heterocyclic imino derivatives are disclosed, as well as several processes for preparing the same and their use for pest control.
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WO/1995/032952A1 |
Compounds of formula (I), wherein the substituents are as defined in claim 1 are prepared by: preparing a compound of formula (IV); converting that compound in the presence of an enaminating agent into the compound of formula (III); reac...
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WO/1995/026959A1 |
A novel alkylenediamine derivative having the effect of inhibiting dysuria occuring under a high intravesical pressure and represented by general formula (1) wherein R1 represents hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, nit...
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WO/1995/027202A1 |
The current invention concerns the use of a receptor from the RZR/ROR receptor family or of a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor, melatonin-like and/or melatonin-antagonist...
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WO/1995/025104A1 |
A compound of the formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein, X represents a moiety of formula (a), in which A1 represents -CH=CH=, NH, S or O; A2 represents an o...
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WO/1995/022326A1 |
A cholinesterase activator containing a compound represented by general formula (I) (wherein A represents phenyl, indanyl, etc.; B represents prolyl, thioprolyl, etc.; and m represents an integer of 0 to 5). It has a potent cholinesteras...
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WO/1995/018820A1 |
Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphorothioate, phosphodiester, and phosp...
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WO/1995/018117A1 |
A benzothiazine derivative represented by general formula (I) or a salt thereof, wherein the broken line indicates the presence or absence of a bond; Z represents any of the groups (a), (b), (c), (d), (e), (f), (g) and (h); (wherein R1 r...
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WO/1995/018104A1 |
A novel benzamide derivative represented by general formula (I), or a salt, hydrate or solvate thereof. The compound is useful as a 5-HT4 receptor agonist for preventing and treating central nervous system diseases such as schizophrenia,...
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WO/1995/016679A1 |
Substituted heterocycles of general structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of: hydrogen; C1-6 alkyl, unsubstituted or substituted; C2-6 alkenyl, unsubstitut...
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WO/1995/014928A1 |
Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium in at least a hexacoordinated state and (b) a compound hav...
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WO/1995/014685A1 |
The present invention relates to novel substituted thiosemicarbazone derivatives of formula (I) wherein R1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl...
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