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WO/1999/000115A1 |
The use of antagonist or partial agonists of the vanilloid receptor complexes such as capsazepine or olvanil for the treatment of neurodegenerative diseases.
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WO/1999/000133A1 |
There is disclosed a method for increasing retinal and optic nerve head blood velocity by topical application of a composition comprising carbonic anhydrase inhibitors and hypotonic xanthan gum to the eye.
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WO/1998/058905A1 |
Amidrazone derivatives of formula (I) useful for prevention or treatment of lupus mycosis attributable to fungi, such as Candida, Aspergillus, and Cryptococcus, pharmaceutically acceptable salts thereof, and pharmaceutical compositions t...
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WO/1998/054135A1 |
Compounds represented by general formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds inhibit the biosynthesis of triglycerides in the liver and also inhibit the secretion of lipoproteins containing apol...
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WO/1998/050372A1 |
The invention relates to compounds of formula (I), to the production of said compounds and their use in medicaments.
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WO/1998/050031A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic -L�2?-;...
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WO/1998/050029A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) lower alkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl -L�2?-, and (i) heterocyclic -L�2?...
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WO/1998/050030A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic-L�2?-; ...
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WO/1998/039311A1 |
A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a $g(b)-lactam antibiotic, a therapeutically effective amount of an amino acid derivative or a pharmaceutically accepta...
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WO/1998/038194A1 |
The invention concerns compounds of formula (I) in which R�1? represents a sulphur or selenium atom, R�2? represents hydrogen or alkyl, -R�3?-R�4?-R�5?- represents a chain of formula -CH�2?-CH�2?-CH�2?-, -CH(R�7?)-CH�...
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WO/1998/037079A1 |
$i(N)-Heterocyclic derivatives of formula (I) are described herein, as well as other $i(N)-Heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as ...
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WO/1998/034929A1 |
The invention relates to certain 8-ureido and 8-thioureido 1,2-benzothiazines, 1,2,4-benzothioxazines and 1,2,4-benzothiodiazines useful in the treatment of disease states mediated by the chemokine, Interleukin-8.
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WO/1998/034918A1 |
A compound of formula (I) wherein R?1�, R?2�, R?3�, R?4�, R?5�, R?6�, R?7�, R?8�, R?9� and Q are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue u...
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WO/1998/033496A1 |
Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula (I): R?1�-L-NHSO�2?R?2�, in which R?1� represents an unsubstituted or substituted aromatic or heteroaromatic group; R?2...
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WO/1998/031219A1 |
This invention is directed to a method for inactivating pathogenic contaminants, such as viruses, bacteria, parasites and leukocytes, frequently found in whole blood or blood components, such as red blood cells or plasma, which comprises...
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WO/1998/029399A1 |
The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention includes an anionic portion combined with at least one cationic portion M?+m� in sufficient numbers to ensur...
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WO/1998/029388A1 |
The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention is comprised of an amide or one of its salts, including an anionic portion combined with at least one cationic...
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WO/1998/029877A1 |
Disclosed is a proton conductor in liquid form, comprised of a mixture of the following components: (a) a salt combined with a nitrogenated base along with an acid, according to formula (I), wherein Z�1?, Z�2?, Z�3?, and Z�4?, wh...
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WO/1998/029389A1 |
The invention is related to ionic compounds, derivatives of malononitrile, in which the anionic load has been displaced. An ionic compound disclosed by the invention includes an anionic portion combined with at least one cationic portion...
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WO/1998/029396A1 |
The invention relates to ionic compounds in which the anionic load has been displaced, and the uses of these compounds. A compound disclosed by the invention comprises an anionic portion combined with at least one cationic portion M?+mï¿...
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WO/1998/029358A2 |
Disclosed is a method for grafting a polymer onto the surface of a carbonate material with carboxyl, amine, and/or hydroxyl functions on its surface. Said material is placed in suspension in a solution including the polymer to be grafted...
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WO/1998/028313A1 |
A compound of formula (I), wherein X is carboxy or a group of formula -PO(OH)-R where R is an unsubstituted or substituted hydrocarbyl group, R?1� is a monovalent aromatic or araliphatic group connected through a carbon atom thereof to...
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WO/1998/026792A1 |
The present invention relates to compositions containing betacyanins (betanidins and betanins) and betaxanthins from antioxidant containing fruits and vegetables, preferably red beets, useful for prevention and treatment of disorders and...
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WO/1998/022434A1 |
The invention relates to novel glyoxylic acid amides, a method for the production and the use thereof as pesticides.
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WO/1998/021186A1 |
The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.
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WO/1998/019672A1 |
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO�n?-PDE inhibitor wherein n is 1 or 2. The phosphodiesterase inhibitor can be nitrosylated or nitrosated through sites such as oxygen (hydro...
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WO/1998/019676A1 |
A method of using a compound of formula (I) wherein R?1�, R?2�, R?3�, X and n have any of the meanings defined in the specification, to antagonize glutamate binding, or to treat glutamate-related disorders is provided. Novel compou...
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WO/1998/017267A1 |
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15�, are effec...
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WO/1998/017630A1 |
The invention relates to novel amides of the general formula (I), a method for their production and their use as pesticides.
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WO/1998/014433A1 |
Compounds of the formula (I) wherein R?1� is a group of formula G?1�, G?2�, G?3�, G?4�, G?5�, G?6� or G?7�; Y is an optionally substituted (C�1?-C�4?) heteroalkyl bridge that, together with the atoms to which it is at...
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WO/1998/013357A1 |
Benzo[1,4]thiazine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R?1� represents hydrogen or lower alkyl; R?2� and R?3� are the same or different and each represents hydrogen ...
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WO/1998/013355A1 |
This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin pr...
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WO/1998/008822A1 |
The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as ...
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WO/1998/008825A1 |
The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as ...
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WO/1998/008827A1 |
The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful inh...
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WO/1998/003474A1 |
The invention concerns novel glyoxylic acid derivatives, a process for their preparation and their use as pesticides.
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WO/1997/048681A1 |
Sulphonamide compounds of formula (I) or a salt thereof, wherein: Ar is an optionally substituted mono- or bicyclic aromatic or heteroaromatic ring; R1 and R2 are independently hydrogen, C1-6 alkyl, arylC1-6 alkyl or together with the ni...
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WO/1997/047625A1 |
Tricyclic compounds of general formula (I) as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases character...
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WO/1997/045115A1 |
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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WO/1997/040029A1 |
There are described compounds of formula (I*) wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubsituted or substituted by one or more lower alkoxy radica...
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WO/1997/036860A1 |
The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (I), and methods of selectively inhibiting or ant...
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WO/1997/033871A1 |
Novel phenothiazine, acridan, acridone oxime, acridone hydrazone, and dibenzodiazepine derivatives which are effective in the prevention and treatment of diseases in which histamine, leukotriene, etc., participate. Phenothiazine, acridan...
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WO/1997/033878A1 |
A method for preparing compounds of formula (I), wherein X, i, j, R1, R2, R3 and R4 are as defined in claim 1, by (i) reacting a derivative of formula (II) with an acrylonitrile derivative of formula (III) in a polar medium consisting of...
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WO/1997/033866A1 |
'beta'-anilinoethanethiol compounds of general formula (1) (wherein R is hydrogen or optionally substituted alkyl or aryl; R1 is optionally substituted alkyl or optionally substituted aryl); a process for the preparation of 'beta'-anilin...
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WO/1997/032864A1 |
Novel spherical 10-phenothiazinylpropanoic acid agglomerates and a method for preparing same are disclosed. According to the method for preparing spherical 10-phenothiazinylpropanoic acid agglomerates, a suspension of 10-phenothiazinylpr...
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WO/1997/030054A1 |
The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indol...
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WO/1997/026884A1 |
This invention is a novel treatment for sexual dysfunctions by administering to a subject exhibiting a sexual dysfunction compounds that upmodulate the AMPA receptor. Methods and compositions for treating sexual dysfunction are provided....
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WO/1997/026018A1 |
A method for in-vivo detection of premalignant oral lesions and oral carcinomas includes the step of applying to oral tissue a non-toxic dye other than toluidine blue O, selected from compounds having structure (I), and ionic derivatives...
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WO/1997/021689A1 |
N-Phenylcarbamate compounds represented by formula (1) and agricultural or horticultural bactericides comprising the same as the active ingredient, wherein R1 represents hydrogen, C2-5 alkoxyalkyl, C2-5 alkynyl, C1-4 alkyl, C2-5 alkenyl,...
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WO/1997/021685A1 |
A compound of formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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