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WO/2000/068204A1 |
The invention relates to novel substituted benzoyl ketones of formula (I), wherein n represents 0, 1, 2 or 3; A represents a simple bond or alkanediyl (alkylene); R?1¿ represents hydrogen or optionally substituted alkyl or cycloalkyl; R...
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WO/2000/068227A1 |
The invention relates to substituted benzoylisoxazoles of general formula (I), wherein R?1¿, R?2¿, R?3¿ and (R?4¿) represent hydrogen or certain substituents, a single bond or alkanediyl (alkylene) and an optionally substituted 4-12 ...
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WO/2000/066568A1 |
A compound of formula (I), wherein R¿1? is unsubstituted or substituted aryl or heteroaryl, the substituents of the aryl and heteroaryl rings being selected, for example, from the group consisting of OH, halogen, CN, NO¿2?, C¿1?-C¿6?...
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WO/2000/058293A2 |
The present invention relates to compounds of formula (I) wherein R?1¿, R?2¿, R?3¿ and R?4¿ are as defined in claim 1 and pharmaceutically acceptable salts thereof. The compounds are glucokinase activators which increase insulin secr...
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WO/2000/058306A1 |
The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which Z is a possibly substituted 4 to 12-membered, saturated or unsaturated, monocyclic or bicyclic heterocyclic grouping which contains between ...
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WO/2000/050017A2 |
Use of subtsituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives for the Treatment of Cerebral Diseases, pharmaceutical compositions containing them, and a process for using them. The compounds of the invention have the generali...
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WO/2000/043375A2 |
The invention relates to new substituted aryl heterocyclic compounds of the general formula (I) in which n, Q, R?1¿, R?2¿ and X have the meanings given in the description, to methods for producing same and to their use as herbicides.
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WO/2000/040539A1 |
Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of Respiratory Diseases, pharmaceutical compos...
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WO/2000/037451A1 |
The present invention is concerned with the compounds of formula (I), a $i(N)-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein p is 0 to 4; q is 0 to 5; X is O, S...
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WO/2000/035885A1 |
Hydrazine derivatives of formula (I) wherein W represents O, S, CO, NR?5¿, (CR?3¿R?4¿)¿m?, or CR?11¿; X represents CO, NR?6¿, (CH¿2?)¿n?, CR?12¿ or CHR?13¿; Y represents CO, NR?7¿, (CH¿2?)¿p?, or CHR?14¿; Z represents CO, C...
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WO/2000/035888A1 |
There is disclosed an improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine which process comprises the step of reacting 2,3-dichlorobenzoylchloride with cuprous cyanide in presence of acetonitrile and...
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WO/2000/031053A1 |
The present invention is concerned with the compounds of formula (I) the $i(N)-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 4; -A-B- represents -(C...
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WO/2000/031054A1 |
The present invention is concerned with the compounds of formula (I), the $i(N)-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 5; -A-B- is -(CH¿2?)Â...
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WO/2000/023421A1 |
This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in t...
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WO/2000/017195A1 |
The present invention is concerned with the compounds of formula (I), the $i(N)-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, it further relates to their use as a medicine.
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WO/2000/012084A1 |
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
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WO/2000/010569A1 |
Nitrogenous heterocyclic carboxamide derivatives represented by general formula (I), or salts thereof are useful as preventives and therapeutic agents for infections with viruses, particularly influenza virus. In said formula A is an opt...
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WO/2000/008000A1 |
The invention relates to new substituted triazinones of the general formula (I), in which n, Q, R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ have the meanings given in the description, to methods for producing same and to their use as herbicides.
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WO/2000/005221A1 |
The invention relates to substituted benzoylcyclohexandiones of general formula (I), wherein A represents a single bond or alkane diyl (alkene) and Z represents an optionally substituted 4-12 membered, saturated on unsaturated, monocylic...
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WO/2000/000473A1 |
The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R¿1?, R¿2?, R¿3?, R¿4? represent a hydrogen or an alkyl group, or R¿1? and R¿3? together form a cycloalkyl group; R¿5? represents a hydrogen, an alkyl...
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WO/1999/062520A1 |
Certain six-membered aromatic and heteroaromatic-dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV...
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WO/1999/061413A1 |
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula: (T)¿x?A-B-D-E...
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WO/1999/059983A1 |
The invention relates to substituted 6-aryl-3-thioxo-5-(thi)oxo-2,3,4,5-tetrahydro-1,2,4-triazine
s of formula (I) and to their salts. In said formula, R?1¿ is C¿1?-C¿6?-alkyl, C¿1?-C¿6?-halogen alkyl, and possibly substituted pheny...
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WO/1999/055668A1 |
3-Arylphenyl sulfide derivatives represented by general formula (I) and insecticides and miticides containing these derivatives as the active ingredient, wherein R represents C¿2?-¿6? alkyl, C¿2?-¿6? alkenyl, C¿2?-¿6? alkynyl, etc....
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WO/1999/054311A1 |
The invention relates to novel diphenyl-substituted 6-ring-heterocycles of general formula (I), wherein A, X and the radicals R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ have the meanings given in the description. The invention also relates to ...
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WO/1999/040910A1 |
Compounds of general formula (I) wherein R¿4? is an ester or thioester group and R, R¿1?, R¿2?, and R¿3? are as specified in the description, inhibit intracellular Leukotriene A¿4? hydrolase activity and are therefore of value for t...
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WO/1999/041245A1 |
Insecticidal dihydro-oxadiazine compounds having formula (I): wherein X is O, N or S; R is a substituted or unsubstituted phenyl or C¿4?-C¿5? heterocyclic group; R?2¿, R?3¿, R?4¿, and R?5¿ are one of the following: a) R?2¿, R?3¿,...
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WO/1999/032462A1 |
A compound of formula (I) and pharmaceutically acceptable prodrugs, salts and solvates thereof.
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WO/1999/026909A2 |
The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R¿1? is C¿4-12? alkyl, C¿4-12? alkenyl, C¿4-12? alkynyl, -(CH¿2?)¿h?-C¿3-8? cycloalkyl, substituted and unsubstituted -(C...
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WO/1999/020622A1 |
The invention concerns novel 3-oxo-(2H)-1,2,4-triazine derivatives of general formula (I) in which R¿1? represents: hydrogen, when A is an optionally substituted nitrogen atom; a linear or branched C¿1?-C¿4? alkyl group; a C¿1?-C¿4?...
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WO/1999/020613A1 |
The invention concerns novel cyclohexane derivatives difunctionalised in 1,4 of general formula (I) in which A represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl or pyrimidinyl optionally ...
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WO/1999/019296A1 |
Aminobutanoic acid derivatives represented by general formula (I) and salts thereof (wherein each symbol is as defined in the description). The derivatives inhibit matrix metalloproteinases and are therefore useful for the prevention and...
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WO/1999/017776A1 |
Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
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WO/1999/011634A1 |
The present invention relates to compounds represented by formula (I) wherein ring H represents an optionally substituted aromatic heterocyclic group or an optionally substituted alicyclic hydrocarbon group; X and Y independently represe...
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WO/1999/007352A2 |
Method of promoting expression of LDL receptor gene and an agent therefor, which comprises as an active ingredient a 1,2,4-triazin-5-one derivative of formula (I), wherein R?1¿ is unsubstituted or substituted phenyl, unsubstituted or su...
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WO/1999/005125A1 |
The invention relates to substituted n-aryl-n-thioxocarbonyl sulfonamides of general formula (I), wherein the radicals R?1¿ to R?4¿ have the meanings given in the Description. The invention also relates to a method for producing the in...
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WO/1999/002505A1 |
The present invention is concerned with the compounds of formula (I) the $i(N)-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomerics forms thereof, p and q are 0, 1, 2, 3 or 4 and q is also 5; X is O, ...
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WO/1999/002504A1 |
The present invention is concerned with the use of compounds of formula (I): the $i(N)-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q represent...
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WO/1998/058916A1 |
The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin rece...
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WO/1998/050031A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic -L�2?-;...
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WO/1998/050029A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) lower alkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl -L�2?-, and (i) heterocyclic -L�2?...
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WO/1998/050030A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic-L�2?-; ...
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WO/1998/042686A1 |
LDL receptor gene expression promoters containing 1,2,4-triazine derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof, which can increase the expression dose (amount of mRNA) of the LDL receptor gen...
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WO/1998/039304A1 |
New substituted aromatic amino compounds are disclosed having the general formula (I), in which R?1�, R?2�, R?3�, R?4� and Z have the meanings given in the description, as well as a process for preparing the same and their use as...
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WO/1998/029399A1 |
The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention includes an anionic portion combined with at least one cationic portion M?+m� in sufficient numbers to ensur...
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WO/1998/029388A1 |
The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention is comprised of an amide or one of its salts, including an anionic portion combined with at least one cationic...
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WO/1998/029877A1 |
Disclosed is a proton conductor in liquid form, comprised of a mixture of the following components: (a) a salt combined with a nitrogenated base along with an acid, according to formula (I), wherein Z�1?, Z�2?, Z�3?, and Z�4?, wh...
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WO/1998/029389A1 |
The invention is related to ionic compounds, derivatives of malononitrile, in which the anionic load has been displaced. An ionic compound disclosed by the invention includes an anionic portion combined with at least one cationic portion...
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WO/1998/029396A1 |
The invention relates to ionic compounds in which the anionic load has been displaced, and the uses of these compounds. A compound disclosed by the invention comprises an anionic portion combined with at least one cationic portion M?+mï¿...
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WO/1998/029358A2 |
Disclosed is a method for grafting a polymer onto the surface of a carbonate material with carboxyl, amine, and/or hydroxyl functions on its surface. Said material is placed in suspension in a solution including the polymer to be grafted...
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