Heterocyclic Compounds

Matches 301 - 350 out of 2,717	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2007/077469A1	OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and ...
WO/2007/079078A1	DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable...
WO/2007/079003A2	AMIDE INHIBITORS OF LEUKOTRIENE A4 HYDROLASE This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 and R10 are described herein, or pharmaceutically acceptable salts, solvates, polymorphs, ammonium ion...
WO/2007/078808A2	METHOD FOR ISOLATING (R)-TOFISOPAM The present invention is directed to a process for the isolation of (R)- tofisopam with high enantiomeric purity and high overall yields from a mixture of tofÊsopam enantiomers by means of a non-simulated moving bed chromatographic proc...
WO/2007/076555A2	A LOCATION BASED WIRELESS COLLABORATIVE ENVIRONMENT WITH A VISUAL USER INTERFACE A wireless networked device incorporating a display, a video camera and a geo-location system receives geo-located data messages from a server system. Messages can be viewed by panning the device, revealing the message's real world locat...
WO/2007/074130A2	3-(4-PIPERIDINYL)-2,3,4,5-TETRAHYDRO-1,3-BENZODIAZEPINE-2(1H)-ONE The invention relates to a method for producing the compound 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepine-2(1H )-one of formula (I), which can be found as a structural element in CGRP antagonists that are suited especially for...
WO/2007/074130A1	3-(4-PIPERIDINYL)-2,3,4,5-TETRAHYDRO-1,3-BENZODIAZEPINE-2(1H)-ONE The invention relates to a method for producing the compound 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepine-2(1H )-one of formula (I), which can be found as a structural element in CGRP antagonists that are suited especially for...
WO/2007/072974A1	P2X4 RECEPTOR ANTAGONIST A compound represented by the general formula (I) below or a salt thereof is used as a P2X4 receptor antagonist. (I) (In the formula, X represents S or CH2; Y represents O, S or NH; R1 represents a hydrogen atom, an alkyl group having 1-...
WO/2007/053618A1	PRODRUGS OF MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS Compounds are described that are prodrugs to active compounds that modulate a muscarinic receptor. In some cases, the compounds are prodrugs to. N-desmethylclozapine. The compounds may be used to treat neuropsychiatric disorders.
WO/2007/053145A1	HALOPERIDOL ANALOGS Haloperidol analogs that conforms to the structural formulae [I]; wherein: R is H, or -(CH2)n-OH, n is an integer from 0 to 2, and A is a heterocyclic bridging group, consisting essentially of carbon and at least one nitrogen atom, which...
WO/2007/053193A2	UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present inventio...
WO/2007/040840A2	AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versu...
WO/2007/036532A2	SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS The invention relates to CGRP antagonists of general formula (I), in which R1, R2, R3 and R4 are described in Claim 1, to the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof, to the hydrates of the sa...
WO/2007/038512A2	PHOSPHATE PRODRUGS OF A FARNESYL DIBENZODIAZEPINONE, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
WO/2007/036533A2	SELECTED CGRP ANTAGONISTS, A METHOD FOR THE PRODUCTION THEREOF AND USE IN THE FORM OF DRUGS The invention relates to CGRP-antagonists of general formula (I), wherein R1, R2, R3, R4 and R5 are defined in claim 1, to the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures salts and salt hydrates thereof, in particu...
WO/2007/034127A1	BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: - R1 represents C1-6 alkyl, aryl or heteroaryl;...
WO/2007/026254A2	BENZODIAZEPINE DERIVATIVES , THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF The invention relates to benzodiazepine derivatives having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous syste...
WO/2007/022638A1	BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE This invention relates to compounds for the inhibition of histone deacetylase More particularly, the invention provides for compounds of formula (I): wherein A, B, D, E, X1, X2, X3, X4 and n are as defined in the specification A method o...
WO/2007/023273A1	CELL MIGRATION MODULATING COMPOUNDS The described invention relates to compounds (I) which modulate cell migration, and find use in, for example, wound healing, cancer progression and angiogenesis. All definitions as in claim 1.
WO/2006/117672A2	DETECTION OF ORTHO-DIAMINE RESIDUES IN ANALYTES CONTAINING RESIDUAL CYCLIZING AGENTS BACKGROUND OF THE INVENTION The present invention relates to a novel method for the analytical determination of an aromatic ortho diamine contaminant in a pharmaceutical compound or intermediate thereof prepared by treating said aromatic ortho diamine with a cycliz...
WO/2006/111371A1	PHARMACEUTICALLY ACTIVE DIAZEPANES Leukocyte Function-Associated Antigen One (LFA-1) is a cell adhesion molecule selectively expressed on leukocytes, and plays a major role in the activation and trafficking of T lymphocytes in the tissue at sites of inflammation. In the l...
WO/2006/110198A1	SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES Disclosed are carbenes of the general formula (I), and including salts thereof, and metal complexes thereof. The carbenes are useful in any reaction where carbenes and carbene-metal complexes are used. The carbenes disclosed herein are p...
WO/2006/106241A1	PIPERAZINE DERIVATIVES AND USE THEREOF AS SEROTONIN REUPTAKE INHIBITORS OR AS NEUROKININ ANTAGONISTS The invention relates to a compound of formula (I) in which: R1, R2, R3, R4, while being identical or different, each represent an atom or group selected among H, halogen, alkyl, alkoxy, phenyl and cyano; X represents a bond, an oxygen a...
WO/2006/104008A1	UREA DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE OF THESE A urea derivative represented by the following general formula (I). It has irritative activity on a V2 receptor and is useful as a preventive or therapeutic agent for central diabetes insipidus, night frequent urination, night enuresis, ...
WO2005064008A9	METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Composit...
WO/2006/097449A1	N-HYDROXYAMIDES OMEGA-SUBSTITUTED WITH TRICYCLIC GROUPS AS HISTONE DEACETYLASE INHIBITORS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS New N-hydroxyamides of n-alkyl carboxylic acids omega substituted with suitable tricyclic systems characterised by a central 7-membered ring, having activity as inhibitors of histone deacetylase (HDAC).
WO/2006/091592A1	NAPHTHALENE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR The present invention relates to naphthalene derivatives of formula (I) that are modulators of the glucocorticoid receptor, and to processes for the preparation and use of the same.
WO/2006/085096A1	LIGANDS FOR G-PROTEIN COUPLED RECEPTORS The invention provides compounds of general formulae I - IV or pharmaceutically acceptable salts thereof : Formulas (I), (II), (III), (IV) The invention also provides methods of preparing the compounds, pharmaceutical compositions compri...
WO/2006/084870A2	ALKYL SUBSTITUTED HOMOPIPERAZINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS This invention relates to novel alkyl substituted homopiperazine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to p...
WO/2006/081332A1	SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds having the formula: (see formula I) and pharmaceutically acceptable salts and/or esters thereof, wherein - n is 0, 1, 2, 3, or 4; - A, when present is a lower...
WO/2006/077793A1	ANTITUMOR AGENT An antitumor agent, a medicine, which is useful for the treatment or prevention of digestive cancer, leukemia, pituitary tumor, small-cell lung cancer, thyroid cancer, and neuroastrocytic tumor. The antitumor agent contains as an active ...
WO/2006/071775A2	NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the com...
WO/2006/070878A1	CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF It is intended to provide a compound which has an anticoagulant effect based on the inhibition of the activated blood coagulation factor VII and, therefore, is useful as a blood coagulation inhibitor or a preventive/remedy for diseases c...
WO/2006/067114A1	SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF The present invention is related to derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer...
WO/2006/065479A2	SUBSTITUTED PHENOLS AS ACTIVE AGENTS INHIBITING VEGF PRODUCTION The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.
WO/2006/065826A2	PROCESS TO CHIRAL BETA AMINO ACID DERIVATIVES BY ASYMMETRIC HYDROGENATION The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an ena...
WO/2006/059801A1	7-MEMBERED RING COMPOUND, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF A 7-membered heterocyclic compound represented by the formula (I): (I) a salt thereof, or a solvate of either. They have chymase inhibitory activity and are useful as a medicine for the prevention or treatment of various diseases in whic...
WO/2006/057460A1	NITROGEN-CONTAINING FUSED RING COMPOUND AND USE THEREOF An URAT1 activity inhibitor which contains a nitrogen-containing fused ring compound represented by the following general formula [1]: [1] wherein each symbol is as defined in the description. This URAT1 activity inhibitor is useful in, ...
WO/2006/054560A1	AROMATIC AMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICAL USES OF BOTH Aromatic amide derivatives represented by the general formula (I) which have V2 receptor stimulating activity and are useful as preventive or therapeutic agents for diabetes insipidus, night pollakisuria, night enuresis, overactive bladd...
WO/2006/051851A1	2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the general formula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable salt thereof. They are useful as a therapeutic/preventive agent for diabetes, diabeti...
WO/2006/051312A1	GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS This invention relates to a compound of formula (I) wherein the variables are as defined in the specification. The compound is useful for the treatment of gastrin related disorders.
WO/2006/049984A2	NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS The invention is directed to novel [1,4]benzodiazepine compounds useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising...
WO/2006/046030A2	TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, A, Ar, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their ...
WO/2006/034567A1	USE OF COMPOSITIONS COMPRISING FARNESYL DIBENZODIAZEPINONES FOR TREATING NEOPLASTIC CELLS AND CONDITIONS This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms using the farnesylated dibenzodiazepinone compound of Formula I. The invention includes pharmaceutical co...
WO/2006/034574A1	DIBENZODIAZEPINONE ANALOGUES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS The invention relates to biologically active dibenzodiazepinone analogues represented by Formula (I) where R1 is a linear C1-10 alkyl and the farnesyl moiety can have one, two or three hydrogenated or hydroalkoxylated double bonds), or a...
WO/2006/028161A1	SEROTONIN 5-HT3 RECEPTOR AGONIST Disclosed is a serotonin 5-HT3 receptor agonist which contains a compound represented by the general formula (1) below or a physiologically acceptable salt thereof as an active constituent and has both serotonin 5-HT3 receptor antagonizi...
WO/2006/021833A2	BISBENZAMIDINES FOR THE TREATMENT OF PNEUMONIA A method of combating infectious agents, such as Pneumocystis pneumonia, and a method of treating a subject in need of such treatment is disclosed. The method comprises administering to the subject a bis-benzamidoxime of formula (I) wher...
WO/2006/020817A1	NOVEL SEROTONIN RECEPTOR LIGANDS AND THEIR USES THEREOF The present invention discloses novel 5-HT receptor binding agents of Formula 3, wherein X is -CH or -N-. Y is selected from the group consisting of -CR10R11, -NR12, -0-, -S-, -SO-, and -SO2-. R1 to R12 are various substituents selected ...
WO/2006/020959A2	SUBSTITUTED BENZOFUSED HETEROCYCLES The present invention relates to the compounds of Formula (I), their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of ...
WO/2006/019975A1	1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds of formula (I) and pharmaceutically acceptable derivatives thereof, pharmaceutical com...

Matches 301 - 350 out of 2,717	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >