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WO/2010/125136A1 |
The present invention relates to novel benzenesulfonanilide compounds of the Formulae (I) and (I') and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess valuable therapeutic properties and are ...
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WO/2010/123956A2 |
Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or ...
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WO/2010/121164A2 |
The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided.
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WO/2010/113458A1 |
Disclosed is a commercially advantageous method for manufacturing a 1,5-benzodiazepine compound. A compound (5) is obtained from a reaction formula and used as an intermediate.
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WO/2010/107768A1 |
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventin...
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WO/2010/102513A1 |
Disclosed are new homopiperazine acethydrazide derivatives of formula I or formula II, the definition of each symbol is shown as the description. The method for preparing said homopiperazine acethydrazide derivatives, the uses of said ho...
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WO/2010/096854A1 |
The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-3 receptor (MC3R) and / or the melanocortin-4 receptor (MC4R). Compounds of this invention can be used to ...
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WO/2010/096853A1 |
The present invention provides compounds of Formula (I) that are useful for binding and/or modulating the biological activity of the melanocortin-1 receptor (MC1R). Compounds of this invention can be used to treat diseases and/or conditi...
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WO/2010/095766A1 |
The present invention relates to a compound represented by a formula (I): wherein R1 represents a halogen atom or the like; R2 represents a hydrogen atom or the like; R3 and R4 each independently represents lower alkyl; R5 represents phe...
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WO/2010/090300A1 |
Diazepinedione derivatives represented by general formula (I) or pharmacologically acceptable salts thereof are used as P2X4 receptor antagonist. In general formula (I), R1 represents a hydrogen atom, a C1-8 alkyl group, or the like; R2 ...
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WO/2010/084979A1 |
The present invention relates to a compound represented by the formula(I):wherein R1 represents a hydrogen atom or the like;R2 represents lower alkyl or the like;R3 and R4 represent lower alkyl or the like;R5 represents phenyl or the lik...
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WO/2010/051206A1 |
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present inven...
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WO/2010/047982A1 |
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invent...
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WO/2010/048138A1 |
A method for making the compound of the formula (I), (IV), (VI), (VII) and (VIII), wherein R1 is C-1-5-alkyl, C(O)-O benzyl, C(O)-O-tert.butyl or benzyl; and R2 is C1-C6 alkyl.
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WO/2010/046929A2 |
Disclosed herein are novel crystalline polymorphic forms Form I, Form II, Form III, Form IV, Form V, Form VI, Form VII, Form VIII, Form IX, Form X and amorphous form of temazepam characterized by X-ray powder diffraction patterns, DSC, T...
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WO/2010/026989A1 |
Disclosed is a novel herbicide. Specifically disclosed is a haloalkylsulfonanilide derivative represented by general formula (1) [wherein A represents –C(R7)(R8)- or –N(R9)-; W represents an oxygen atom or a sulfur atom; n represents...
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WO/2010/015613A1 |
The present invention relates to compounds of Formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain ...
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WO/2010/016554A1 |
Disclosed is a compound represented by formula (Ia) [wherein each symbol is as defined in the description] or a salt thereof. The compound has an inhibitory activity on the reuptake of a monoamine, and is therefore useful as a therapeut...
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WO/2010/012619A1 |
The invention is concerned with novel heterocyclyl compounds of formula (I) wherein A, X, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable salts thereo...
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WO/2010/006938A1 |
The invention is concerned with novel heterocyclyl compounds of formula (I); wherein A, X, Y1, Y2, Y3, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable...
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WO/2010/006792A1 |
The invention relates to an innovative process for the synthesis of cyclic amidines. The synthesis starts from a ß-, γ- or δ-lactone, which is dibrominated. Following esterification of the carboxyl function, the bromine atoms are subj...
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WO/2009/156678A2 |
The invention relates to the fumarate salt of 4-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate, to the two crystalline forms thereof, to a method for the preparation thereof and to the therapeutic use thereof.
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WO/2009/156776A1 |
The present invention relates to the process for the preparation of 1-(3,4-dimethoxy-phenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2
,3-benzodiazepine of the Formula (I) by reacting 3,4,3',4'-tetramethoxy-6-(α-aceto-propyl)-benzofenon of th...
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WO/2009/145357A1 |
It is intended to provide a benzodiazepine compound useful in the production of an antidepressant drug that has a wider therapeutic spectrum and can exert sufficient therapeutic effects in a short period. The benzodiazepine compound of t...
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WO/2009/145219A1 |
Disclosed is a means for treating Alzheimer's disease, which utilizes a secretase inhibitor and is highly safe. Specifically disclosed is a compound represented by general formula (I) [wherein A represents a phenyl group or the like; R1...
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WO/2009/139168A1 |
Disclosed is a therapeutic and/or prophylactic agent for cancer pain, which can be administered continuously for a long period between the early stage and the final stage of the cancer pain therapy in place of conventional non-opioid or ...
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WO/2009/138438A1 |
101 Abstract. The present invention relates tohexafluoroisopropanol derivativeshaving the general formula I X O N N Y OH F 3 C CF 3 A R 1 R 2 R 3 ( ) n W Z B R 6 5 Formula I to pharmaceutical compositions comprising the same and to the u...
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WO/2009/093269A9 |
The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The in...
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WO/2009/119528A1 |
Disclosed is a compound having an inhibitory activity on the intake of a monoamine neurotransmitter. Specifically disclosed is a compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof...
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WO/2009/105824A1 |
The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which do...
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WO/2009/105823A1 |
The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which do...
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WO/2009/105825A1 |
The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which do...
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WO/2009/104819A1 |
The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel or the IKACH current (the GIRK1/4 channel) potently and more selectively than other K+ channels. The benzodiazepine compound...
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WO/2009/100996A2 |
The present invention provides innovative strategies for synthesizing pyrazole ring- functionalized benzodiazepinones. Alternative intermediates and high conversion strategies for forming alpha-aminobenzophenone intermediates involve a c...
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WO/2009/102460A2 |
This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 la1-3-lj1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of...
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WO/2009/081349A1 |
Novel hydroxamate histone deacetylase inhibitors of formula (I) wherein X is C=O or CH2 used as antineoplastic agent.
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WO/2009/075691A1 |
Disclosed herein is a compound of Formula (1). Also disclosed herein is a method o modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or cond...
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WO/2009/068595A1 |
This invention relates to novel carboxylic acid 4-phenylazo-phenyl ester derivatives/ of Formula (I), useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a me...
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WO/2009/060208A1 |
A compound of formula I: wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R2 is selected from -H, -OH, =O, =CH2, -CN, -R, OR, halo, =CH-R, O-SO2-R, CO2R and COR; R7 is selected from H, R, OH, O...
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WO/2009/061916A2 |
The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasi...
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WO/2009/059047A2 |
The invention provides tricyclic compounds of the formula: or a pharmaceutically acceptable salt or a pro-drug thereof, where R1, R2, X, Y, n, A, and B are those defined herein. The invention also provides compositions comprising the sam...
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WO/2009/058238A1 |
The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The i...
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WO/2009/053763A1 |
The present invention relates to new non-peptide derivatives of formula (I), wherein R1 -R5, Q and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selecti...
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WO/2009/043747A2 |
The invention is concerned with novel biaryl derivatives of Formula (I), wherein Formula (A), m, R1, R2, R3, X1, X2 and X3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These co...
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WO/2009/044007A2 |
The invention relates to 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide and 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxami
de derivatives of general formula (I), where R1 = H, C1-C10alkyl, C3-C7 cycloalkyl, (CH2)n-(...
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WO/2009/037642A1 |
Disclosed are heterocyclic scaffolds useful, for example, for solid-phase organic synthesis of combinatorial libraries and methods for the preparation thereof. Also disclosed are libraries, including combinatorial libraries, and methods ...
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WO/2009/037302A1 |
Novel 7, 8 dialkoxy-5 - (amino alkyl phenyl) - 1, 4 -benzodiazepines of formula I with said amino being substituted or forming a nitrogen containing heterocyclic alkyl ring, which 1, 4- benzodiazepines are inhibitors of phosphordiesteras...
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WO/2009/024550A1 |
The present invention relates to N-benzyl,N' -arylcarbonylpiperazine derivatives having the general Formula (I) to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N' -arylcarbonylpiperazine derivatives...
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WO/2009/023664A2 |
In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11BETA-hydroxysteroid dehydrogenase type-1, pharmaceutical compositions containing the ...
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WO/2009/021944A1 |
The present invention relates to compounds of the general formula (I), wherein A, B, D, Y, R1, R2, R3, R4 and R5 are defined as mentioned in the description, the enantiomers, diastereomers, mixtures, and salts thereof, particularly physi...
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