| Document |
Document Title |
|
JP3910446B2 |
Neuropeptide Y5 receptor antagonist comprises new or known aminosulfinyl or aminosulfonyl derivatives (I). Neuropeptide Y5 receptor antagonist comprises aminosulfinyl or aminosulfonyl derivatives of formula (I), their prodrugs, salts or ...
|
|
JP2007509165A |
The invention relates to the use of NMDA receptor antagonists such as 1-aminocyclohexane derivatives to modify deposition of potentially toxic and fibrillogenic Abeta peptides in amyloidopathies. Specifically, the invention relates to th...
|
|
JP3902993B2 |
To provide a novel fluorene compound and a highly durable organic light emitting element emitting light at high efficiency and luminance by using the fluorene compound. The fluorene compound is represented by formula [I] and is exemplifi...
|
|
JP3901234B2 |
To obtain the subject compound represented by a specific formula, and usable as an effective medicament for treatment of atherosclerosis and coronal heart disease. The objective compound is represented by formula I [R1 and R2 form phenyl...
|
|
JP3892035B2 |
Acridans which are reactable with a peroxidase and peroxide. The acridans are characterized by having an aromatic leaving group ArO which is a di- or polyhalosubstituted phenoxy group. The compounds are useful in assays where one member ...
|
|
JP3887020B2 |
The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective a...
|
|
JP3862747B2 |
The present invention provides an anticancer compound having the structure: +TR independently -H, -OH, -NH2, -OCH3, -C(CH3)3, or a halogen atom; n is 2 to 6; X and X' are independently -N or -NO2; Y and Y' are independently -N, -CH, or -...
|
|
JP2006528245A |
The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischem...
|
|
JP3856463B2 |
Cpds. of formula I-(T)m (I) and their acid addn. salts are new. Where, I = (hetero)aromatic segment; T is of formula (II), if n is greater than 1; X = N or S; R, R1 and R2 = alkyl, (hetero)alicyclic or (hetero)aromatic gps.; R3 and R4 = ...
|
|
JP3848224B2 |
To provide a novel spiro compound and a highly durable organic light emitting element emitting light at high efficiency and luminance by using the spiro compound. The spiro compound is represented by formula [I]. In formula [I], R1, R2, ...
|
|
JP3844358B2 |
Novel acridinium esters that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays (e.g., immunoassays and gene probe assays) with improved sensitivity are disclosed. In addition, the ...
|
|
JP2006524694A |
Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with pyridinic compounds to produce functionalized pyridinic compounds.
|
|
JP2006292771A |
To provide illuminant 10,10'-substituted-9,9'-biachlysine molecule which can be combined with other molecules.This molecule can be combined with other molecules, such as biachlysine derivatives 10,10'-para-toluic acid-9,9'-biachlydine, e...
|
|
JP3838814B2 |
To obtain the subject novel compound, capable of expressing an emission with sufficient brightness, especially the emission at a long wave and excellent in durability of continuing good emitting performance for a long time. This compound...
|
|
JP2006523681A |
Compound that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods of inhibiting the DNA-PK biological activity, methods of sensitizing cells the agents that cause DNA lesions, and methods of potentiating ...
|
|
JP2006522814A |
This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in ...
|
|
JP2006269834A |
To provide an organic electroluminescent element which has a long emission life and low energy consumption.In an organic EL element 10, (A) hydrogen atom is bonded to carbon atom of α rank in enamine skeleton between an anode 2 and a ca...
|
|
JP3828150B2 |
A chemiluminescent assay method, compositions and kits are described which use a protected phenolic enhancer compound which is deprotected by a hydrolytic enzyme and then enhances a chemiluminescent reaction. The reaction involves an acr...
|
|
JP3819294B2 |
Chemiluminescent substrates of hydrolytic enzymes are disclosed having general Formula Lumi-M-P, where Lumi is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached, wherein the ...
|
|
JP2006519258A |
The present invention relates to urotensin II receptor antagonists, pharmaceutical compositions containing them and their use.
|
|
JP3807781B2 |
To obtain a compound useful as a labeling substance capable of labeling in a short time in high efficiency and having high sensitivity by introducing a chemoluminescent group into a carbodiimide compound. This carbodiimide compound conta...
|
|
JP2002519412A5 |
|
|
JP2006166920A |
To provide a method for identifying organic nonpeptide compound stabilizing functional conformation of p53 family protein.The pharmaceutical compounds are provided in the field of cancer treatment, wherein the provided are ones capable o...
|
|
JP3776229B2 |
To measure the peroxidase activity with high sensitivity by employing a reaction mixture obtained through reduction of A): N,N'-di substitution-9,9'-bis dihydroacridine derivative or B): N,N'-di substitution-9,9'-bis acrridium salt of sp...
|
|
JP3745112B2 |
|
|
JP3737164B2 |
To obtain a golden or maroon solid solution pigment having a high saturation. light fastness of color and weather fastness of color by forming a solid solution comprising a quinacridonequinone component, a quinacridone component, a pyrro...
|
|
JP3720709B2 |
A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
|
|
JP3720977B2 |
To provide a novel chemiluminescent reagent which enables the measurement of the activity of an peroxidase enzyme in the presence of hydrogen peroxide or the like and can be utilized in the detection, microanalysis, or the like of variou...
|
|
JP2005534738A |
Disclosed are compounds of formula:
|
|
JP2005314336A |
To obtain a dermatologic microbicide formulated composition that is obtained by lowering the skin irritation of a dermatologic microbicide and provide a method for lowering the skin irritation.The dermatologic microbicide formulated comp...
|
|
JP3712361B2 |
The present invention relates to new 9-aminoacridine derivatives of general formula (I), wherein A is hydrdogen or (II) (wherein X is oxygen or sulfur, R1, R2, R3, R4 and R5 are independently ydrogen, halogen, nitro, amino, hydroxy, C1-C...
|
|
JP2005274923A |
To prevent the diffusion of an acridone compound before exposure and to improve the solubility of the compound with solvent.The photosensitive resin composition contains a binder, a polymerizable compound, a photopolymerization initiator...
|
|
JP3694044B2 |
PURPOSE: To reproducibly detect a subject substance for inspection with high accuracy and identify various kinds of diseases by using ascorbic acid as a chemiluminescence inducer, allowing an acridinium derivative to efficiently emit lig...
|
|
JP3690825B2 |
PURPOSE: To obtain a heterocyclic ring-containing tricyclic sulfonamide which is represented by a specific formula and has an excellent antitumor activity with low toxicity. CONSTITUTION: The compound of formula I {G is an aromatic 5- or...
|
|
JP2005220095A |
To provide a compound useful as an electrochemical fluorescent display material and electrochromic material free from side reaction, having bistability, enabling the direct control of fluorescence and free from environmental pollution an...
|
|
JP3682974B2 |
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeuticall...
|
|
JP2005519065A |
This invention pertains to certain acridone and acridine compounds of the formula which inhibit telomerase, regulate cell proliferation, etc., and/or treat cancer, proliferative conditions, etc.: wherein either: (a) K is -O, L is -H, alp...
|
|
JP2005518365A |
The present invention is concerned with compounds of the general Formula I: and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such, ...
|
|
JP3662475B2 |
To detect and determine a trace amount of moisture in a medium by using an acridine derivative formed of a nitrogen compound part which can be an electron donative radical and an acridine part as an electron accepting radical. The formul...
|
|
JP2005145853A |
To provide a photocatalyst having an electron transfer state having a high energy and a long life which far exceed charge separation lives and charge separation energies in the photosynthetic reactions of the natural world.This 9-substit...
|
|
JP2005517227A |
A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or va...
|
|
JP2005514396A5 |
|
|
JP2005512998A |
The present invention is directed to the use of anti-malarial compound for the treatment and prophylaxis of infections by adenovirus or rhinovirus.
|
|
JP3642606B2 |
PURPOSE: To form a film having low crystallinity and good amosphous state and to enable luminescence excellent in stability, and reliability by using a tetraarylethene derivative as the organic compound layer of an organic EL element. CO...
|
|
JP2005509648A |
The present invention is directed to a method for treating inflammatory bowel disease in a patient comprising administering to said patient a pharmaceutical composition comprising a pharmaceutically effective amount of an anti-malarial c...
|
|
JP2005504096A |
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...
|
|
JP2005502620A |
Novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electr...
|
|
JP2005500281A |
The present invention relates to substituted hydrazides of a luciferin dye or to substituted hydrazides of a dye analogous thereto. These chemical compounds comprise the luciferin dye or the dye analogue thereto as a light emitting moiet...
|
|
JP2004535423A |
The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precurs...
|
|
JP3584379B2 |
Acridinium compounds represented by the general formula (I) where A is an intervening group which does not have activity for binding with a specific binding substance, Z is a labelling active group which has activity for binding with a s...
|
