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WO/2014/131996A1 |
A method for the enzymatic synthesis of the compound of formula (I). Use thereof in the synthesis of ivabradine and of the pharmaceutically acceptable acid addition salts thereof.
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WO/2014/081275A1 |
The present invention relates to a method for isolating shikimic acid from oil palm waste using resin adsorption and hydrolysis techniques. The method comprises the steps of subjecting an oil palm waste material to resin adsorption to ob...
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WO/2014/020038A1 |
Disclosed is a method for the synthesis of spiro[2.5]octane-5,7-dione useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed are novel intermediates used in the synthesis of this compound.
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WO/2013/181786A1 |
Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the presen...
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WO/2013/178575A1 |
The present invention relates to compounds of general formula I, (I) wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate ...
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WO/2013/007845A1 |
The present invention relates to a method for extraction of maslinic and oleanolic acids and hydroxytyrosol from olive-dressing solutions, which comprises the following steps: a) flocculation of the olive-dressing solutions to obtain a f...
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WO/2012/062041A1 |
Disclosed are aromatic ketone compounds with para- or meso-substituted multifunctional groups as represented by the general formulae I-III, preparation methods thereof, and free-radical polymerization photoinitiators comprising the compo...
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WO/2012/059436A2 |
The invention relates to novel compounds of formula (I), in which R1, R2, R3, R4, R5, Y, Q and G are defined as indicated above, to several methods and intermediate products for the production thereof and use thereof as herbicides and/or...
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WO/2012/055014A1 |
Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH( OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A snd B ...
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WO/2012/017108A1 |
The present invention relates to a method for obtaining maslinic acid and oleanolic acid from olive-pressing waste products, which results in high yields of said compounds in a highly pure form.
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WO/2011/159144A1 |
The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm based waste materials and by-products. The method includes pu...
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WO/2011/153363A1 |
A method is disclosed for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction using a chiral inducing agent. Also described are methods of preparing treprostinil or a pharmaceutically accept...
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WO/2011/110927A1 |
This invention is directed to the production of shikimic acid from Illicium griffithii fruits. The method according to the invention is particularly applicable to the isolation of shikimic acid from Illicium griffithii fruits (seeds and ...
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WO/2011/061744A2 |
The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulati...
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WO/2011/040766A2 |
The present invention relates to a preparation method of 1,4-disubstituted cyclohexane derivatives, and more specifically, to a preparation of 4-(hydroxymethyl)cyclohexanecarboxylic acid useful as a main raw material in fine chemistry su...
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WO/2011/006621A1 |
This invention relates to novel cyclo alkyl compounds suitable for labeling by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, ...
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WO/2010/120232A1 |
There is provided a prodrug of a pharmaceutically active agent, said prodrug comprising a beta-keto carboxylic acid, a beta-keto carboxylic acid salt or a beta-keto carboxylic acid ester functional group, to a pharmaceutical composition ...
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WO/2010/086480A1 |
The invention can be used to: stabilise raw materials from the olive tree, in particular stoned olive pomace and exhausted pomace, maintaining the triterpene content thereof; and prepare a product from these products, having a greater co...
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WO/2010/072813A1 |
The present invention is directed to a compound of formula (I), its diastereoisomers, its enantiomers or its pharmaceutically acceptablesalts or solvates, formula (I), to procedures of obtaining the same, to intermediates thereof, and us...
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WO/2010/045258A2 |
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The pres...
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WO/2010/040460A2 |
The invention relates to novel compounds of formula (I) in which X, Y, Z, A, B, and G have the meanings indicated above, several methods and intermediate products for the production thereof, and the use thereof as pesticides and/or herbi...
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WO/2010/008735A9 |
The present invention provides crystalline and amorphous salts of O- desmethylvenlafaxine and processes for preparing said salts of O- desmethylvenlafaxine. The present invention further provides pharmaceutical compositions comprising sa...
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WO/2010/024298A1 |
Disclosed is a compound represented by formula (I) [wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the description] or a pharmaceutically acceptable salt or solvate thereof.
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WO/2010/010174A1 |
The present invention relates to compounds defined by formula (I) wherein the group R is defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase...
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WO/2010/007253A2 |
A method for preparing the compounds of formula (IV): in which R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a linear or branched (C1-C6) alkyl group, a linear or branched (C1-C6) alkoxy group, a fluor...
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WO/2010/009068A2 |
The present application describes modulators of MCP-1 or CCR-2 of formula,(I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R1, R2, R4 and R6, are defined herein. In addition, methods o...
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WO/2009/151057A1 |
Disclosed is a process for producing carnosic acid (the major antioxidant active substance contained in a rosemary plant) with high efficiency by carrying out the ortho-position oxidation of a phenol with an oxidizing agent (e.g., 2-iodo...
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WO/2009/079876A1 |
Disclosed is the 3-acylated shikimic acid or methyl (ethyl) shikimate derivatives. Shikimic acid is a kind of natural product having physiological activity and has effects on thrombus and alleviating brain damage caused by focal cerebral...
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WO/2009/078813A1 |
A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R1 - R3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R...
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WO/2009/052924A1 |
Catalytic processes for the production of carnosol from carnosic acid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary needles. The catalyst may be iron, iron...
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WO/2009/053026A2 |
Catalytic processes for the production of carnosol from carnosic acid using hydrogen peroxide or a peracid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary ne...
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WO/2009/038978A2 |
Steviol glycoside isomers are provided having the formula (II): wherein R1may be hydrogen, 1-β-D-glucopyranosyl, or 2-(1-β-D-glucopyranosyl)-1-β-D- glucopyranosyl, and R2 may be hydrogen, 1-β-D-glucopyranosyl, 2-(1-β-D-glucopyranosy...
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WO/2008/027570A9 |
The present invention provides a method of isolating shikimic acid from a plant. First, a plant is provided. Next, the plant is grown in the absence of glyphosate for a first time period. The plant is then treated with glyphosate for a s...
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WO/2008/122504A1 |
Compounds of theFormula (I) wherein x is an integer from 1-4; p is an integer from 1-3; q is an integer from 0-3; Ar is phenyl, naphthyl, anthryl or phenanthryl each of which optionally is substituted by one or more Cl, CN, OR5, C3-C5alk...
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WO/2008/111631A1 |
Disclosed is an important production intermediate for an optically active phthalazinone derivative [1], which is useful as a pharmaceutical product, or a pharmaceutically acceptable salt thereof. Also disclosed are a method for producing...
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WO/2008/067713A1 |
Compounds having substituted cyclopentane structure represented by formulas I-IV, their preparation methods, and useful as glucagon like peptide-1 receptor regulator for prevention and/or treatment of metabolic disorders (including, but ...
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WO/2008/067709A1 |
Substituted cyclobutane compounds represented by formula I or II. The preparation method of these compounds and uses thereof as glucagons like peptide-1 receptor(GLP-1R) regulators for preventing and/or treatment of metabolic disorders, ...
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WO/2008/067710A1 |
Substituted cyclohexane compounds represented by any one of formula I-VI. The preparation method of these compounds and uses thereof as glucagons like peptide-1 receptor(GLP-1R) regulators for preventing and/or treatment of metabolic dis...
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WO/2007/138607A1 |
The present invention provides a simple and economical method for extracting shikimic acid in high yield from star aniseeds employing an aqueous polar solvent, wherein said polar solvent is isopropanol. Further, the solvent in the method...
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WO/2007/136572A2 |
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled recepto...
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WO/2007/136574A2 |
According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at...
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WO/2007/013689A1 |
A compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt or prodrug thereof. The compound, salt and prodrug unexpectedly have excellent GPR40 receptor agonistic activity, and also have ex...
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WO/2007/007207A2 |
Pharmaceutical compositions of 3,5-bis(arylidene)-4-piperidones and analogues thereof accordin to Formula Ia useful for the modulation of ce|| proliferation. Formula (Ia).
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WO/2007/004104A2 |
The present invention relates to plant expressing transgenes and to plants transformed to comprise additional copies of genes, said genes encoding at least a HMGR- CoA reductase and a terpene synthase. The invention further claims method...
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WO/2006/126654A1 |
A novel compound having an inhibitory effect on 11β-hydroxysteroid dehydrogenase type 1 (hereinafter referred to as '11β-HSD1'); a pharmaceutical comprising the compound as an active ingredient (preferably a therapeutic/ameliorating ag...
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WO/2006/088716A1 |
The present invention relates to novel tetralin ER-β agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-β mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrop...
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WO/2006/022825A1 |
Various non-limiting embodiments disclosed herein related to photochromic materials comprising the reaction product of (a) at least one ring-opening cyclic monomer, and (b) a photochromic initiator. Other non-limiting embodiments related...
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WO/2006/009266A1 |
A selenium compound, a nitrogenous aromatic compound, and an acid are mixed together optionally in the presence of a solvent to obtain an oxidation catalyst composition. The oxidation catalyst composition obtained shows catalytic activit...
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WO/2005/110958A1 |
Disclosed is a method for oxidizing an alcohol in an amide solvent using a mixed reagent containing hydrogen peroxide and a tungsten catalyst.
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WO/2005/108341A1 |
Disclosed is a method for producing a compound represented by the general formula (II) below which is characterized in that a compound represented by the general formula (I) below is reacted with water without a catalyst or in the presen...
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