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WO/2010/055004A1 |
The invention is concerned with the compounds of formula I, and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1- R7 are defined in the detailed description and claims. In addition, the present invention rela...
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WO/2010/054565A1 |
The present invention provides the water-soluble prodrug of (R)-(-)-bicalutamide as follows of formula (I), its pharmaceutically acceptable salts, its preparation method and uses thereof. The compound of formula (I) is useful for treatme...
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WO/2010/055744A1 |
An aprotic polar solvent having a relatively low melting point and excellent thermal stability, which is chiefly useful as solvents for electrochemical devices and the like. Specifically disclosed is a sulfone compound represented by for...
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WO/2010/049946A2 |
The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes ...
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WO/2010/047257A1 |
An aprotic polar solvent having a relatively low melting point and excellent thermal stability, which is chiefly useful as solvents for electrochemical devices and the like. Specifically disclosed is a sulfone compound represented by for...
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WO/2010/041748A1 |
Disclosed is a prophylactic or therapeutic agent for diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, heart failure, cardiomyopathy, myocardial ischemia, cer...
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WO/2010/038550A1 |
A method for producing a specific amine wherein an extraction/separation step, in which the specific amine is extracted and separated as an organic layer in the co-presence of at least one kind of organic solvent (A) having a dielectric ...
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WO/2010/034999A1 |
A compound of formula (I) in solid form, preferably crystalline form.
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WO/2010/035000A1 |
Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In o...
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WO/2010/029950A1 |
Disclosed are: a process for producing an optically active epoxy compound and an optically active sulfoxide compound; a ligand and a complex for use in the process; and a process for producing the complex. Specifically disclosed are: an ...
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WO/2010/030345A2 |
Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of isoindoline based PDE 4 modulators.
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WO/2010/028088A2 |
Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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WO/2010/027051A1 |
Disclosed is a novel intermediate for producing a substituted isoxazoline compound that is useful as a harmful organism control agent. Specifically disclosed are: a substituted acetophenone compound represented by general formula (1) or ...
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WO/2010/018858A1 |
Disclosed is an organic sulfur compound represented by general formula (a1) [wherein A represents –S-, -S(O)- or –S(O)2-; Z1 and Z4 independently represent a trivalent aromatic hydrocarbon group, or the like; Z2 and Z3 independently ...
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WO/2010/014566A2 |
Processes for preparing oxazoline compounds are disclosed. These oxazoline compounds are useful intermediates in the preparation of Florfenicol and related compounds.
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WO/2010/013352A1 |
Diphenylsulfone crosslinked compounds of the general formula: (1) wherein n is an integer of 1 to 10. Further, there is disclosed a thermal recording material comprising a support and, superimposed thereon, a thermosensitive color formin...
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WO/2010/013567A1 |
Disclosed is a pest control agent having an excellent effect, which contains, as an active ingredient, a compound represented by general formula (1). (In the formula, A represents a carbon atom, a nitrogen atom or the like; K represents...
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WO/2010/009508A1 |
A compound of Formula (A) wherein Z is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the heteroaryl or substituted heteroaryl connected to a 2,4-dinito-6-(trifluoromethyl)phenyl ring via a carbon-carbon bond.
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WO/2010/006725A1 |
A compound of formula (I) wherein A1, A2, A3, A4, G1, G2, R1, R2, L, Q1, and Q2 are as defined in claim 1; or a salt or N- oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds o...
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WO/2010/008299A1 |
The present invention relates to lipid compounds of the general formula (I): (I) wherein R1 is selected from a C10-C22 alkyl, a C10-C22 alkenyl having 1-6 double bonds, and a C10-C22 alkynyl having 1-6 triple bonds;R2 and R3 are the same...
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WO/2010/003127A2 |
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists Of PGD2 receptors. Also described here...
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WO/2009/157418A1 |
Disclosed is a highly safe agent for treating and/or preventing diabetes or the like, which has excellent activity. Specifically disclosed is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (...
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WO/2009/157196A1 |
Disclosed is a compound having GPR52 agonist activity and serving as an agent for preventing or treating schizophrenia or the like. Specifically disclosed is a compound represented by formula (I) or a salt thereof. In the formula, A repr...
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WO/2009/149806A2 |
The invention relates to 4-(3-alkyl sulfinyl benzoyl) pyrazoles of the general formula (I) as herbicides. In said formula (I), R1 through R4, X, and Y stand for radicals such as hydrogen, organic radicals such as alkyls, and other radica...
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WO/2009/147632A2 |
The invention provides a method of preparing the stereoisomers of 1,11-diamino-6-aza- undecane-2,4,8,10-tetraol.
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WO/2009/145219A1 |
Disclosed is a means for treating Alzheimer's disease, which utilizes a secretase inhibitor and is highly safe. Specifically disclosed is a compound represented by general formula (I) [wherein A represents a phenyl group or the like; R1...
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WO/2009/144344A2 |
Compound for labelling biomolecules based on vinylsulphone, preparation and uses, comprising a labelling molecule and a vinylsulphone group. In addition it relates to the use of the compounds as labelling agents, to the procedure of obta...
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WO/2009/140765A1 |
The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases...
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WO/2009/139438A1 |
Disclosed is a process for producing an optically active carboxylic acid from a racemic carboxylic acid in a conventional production facility with high efficiency and at low cost. Specifically disclosed is a process for producing an opt...
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WO/2009/132453A1 |
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of subs...
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WO/2009/132452A1 |
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of subs...
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WO/2009/132832A2 |
The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.
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WO/2009/131065A1 |
Disclosed is a compound useful as a prophylactic agent or a therapeutic agent for cardiovascular diseases, nervous system diseases, metabolic diseases, genital diseases, gastrointestinal diseases, neoplasm, infectious diseases and others...
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WO/2009/128907A1 |
Processes useful for making a pharmaceutically useful compound according to Formula (I), forms of such a compound, and intermediates useful in such processes are described.
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WO/2009/128521A1 |
Disclosed are: a compound having an excellent inhibitory activity on cysteine protease; and a pharmaceutical agent for the treatment or prevention of a disease selected from the group consisting of osteoporosis, osteoarthrosis deformans,...
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WO/2009/125606A1 |
Provided is a compound represented by formula (I) having a PAI-1 inhibiting action. [In formula (I), R1 represents an optionally substituted C6-10 aryl group etc., T represents a single bond etc., m is 0 or 1, when m is 0 G represents -N...
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WO/2009/125861A1 |
Disclosed are a compound having an outstanding cysteine protease inhibiting action, and medicaments for treating or preventing a disorder selected from a set comprising osteoporosis, osteoarthrosis deformans, rheumatoid arthritis, Paget'...
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WO/2009/123109A1 |
A photosensitive transparent resin composition which is reduced in the dependence on exposure illuminance and which can stably form patterns excellent in resolution with high retention of film thickness and nearly without scum; color fil...
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WO/2009/118292A1 |
The present invention provides a compound of formula (I):said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by a...
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WO/2009/120783A1 |
Compositions and uses thereof that inhibit HCV life cycle by inhibiting action of the HCV NS3/4A protease. An embodiment of the invention comprises a compound designated RS-2-19.
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WO/2009/116487A1 |
Disclosed is a method for producing a sulfone compound represented by formula (1), which comprises a step of obtaining a compound represented by formula (4) by reacting a compound represented by formula (3) with a chlorate or a bromate, ...
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WO/2009/114849A1 |
Asymmetric cyclopropanation of olefins with diazosulfones.
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WO/2009/113508A1 |
Disclosed is an acid having a fluorine-containing carbanion structure or a salt having a fluorine-containing carbanion structure, which is represented by general formula (1). By using a photoacid generator for chemically amplified resist...
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WO/2009/109483A1 |
Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing...
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WO/2009/106664A1 |
The invention relates to labelling agents containing a compound with a labelled molecule and a vinyl sulphone group. The invention also relates to the compounds, the method for obtaining same and the uses thereof in the marking of biomol...
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WO/2008/009815A9 |
The invention relates to aromatic sulfonates, the preparation thereof, and the use of the same as the salt of an electrolyte. The sulfonates have the formula [Ar-Z- (CF2)nCFRf-SO3 -] p Mp+ (I), wherein Z is a sulfide, sulfinyl or sulfony...
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WO/2009/097684A1 |
The invention relates to a method for measuring the real temperature of a hot spot in an oil-containing electric apparatus, such as a power transformer. The electric apparatus is operated in predetermined and changeable operating conditi...
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WO/2009/096545A1 |
A diurethane compound R2(SO2)m(CH2)nOCONH-R1-NHCOO(CH2)n(SO2)mR2 is produced by a method in which a diamine compound H2NR1NH2 is reacted with a chloroformate compound ClCOO(CH2)n(SO2)mR2 or by a method in which a diisocyanate compound OC...
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WO/2009/092713A1 |
This invention relates to novel N-(2-methyl-phenyl-cyclopentyl)sulphonamide derivatives of formula (I) and salts thereof: wherein R1, R2, R3, R4, R5, R6, R7, R8, p, R9 and R10 are as defined in the description. The invention also relates...
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WO/2009/090663A1 |
The present invention relates to a novel crystalline polymorph of armodafinil. In another aspect the invention relates to an improved process for preparation of the novel polymorph of armodafinil.
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