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JP4578685B2 |
A compound of the formulawhere the substituents are defined in the specification and its pharmaceutically acceptable salts and prodrugs thereof useful as antagonists of vitronectin receptors.
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JP2010248093A |
To provide an asymmetric reaction wherein an optically active proline derivative is used as a catalyst, an optically active proline derivative, and an organic molecular catalyst including the derivative.There are disclosed an asymmetric ...
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JP4564786B2 |
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JP4550286B2 |
Acylquanidines of the formulawherein the substituents are defined as in the specification which are antagonists of the vitronectin receptor and inhibitors of cell adhesion and bone resorption mediated by the osteoclasts.
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JP4529016B2 |
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JP2010526025A |
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides, ureas and related compounds in therapeutically effective a...
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JP4478157B2 |
A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases ass...
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JP4469424B2 |
A compound of the formulawherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
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JP4467239B2 |
The invention relates to novel substituted benzoylcyclohexenones of the formula (I) in which Q, R1, R2, R3, R4, R5, Y and Z have one of the meanings given in the disclosure, to processes for their preparation, and to their use.
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JP2010090138A |
To provide a novel substituted tetracycline compound useful to treat numerous tetracycline compound-responsive states such as bacterial infections and neoplasms.The compound is represented by formula (I), wherein X is CH2, CH-alkyl or th...
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JP4431959B2 |
Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a com...
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JP4425992B2 |
There are disclosed novel synthetic peptides of the general formula (I) Compounds of formula (I) stimulate the release of growth hormone from the pituitary in humans and animals. A method for increasing the rate and extent of growth of a...
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JP4405549B2 |
The invention relates to a process for preparing semicarbazone compounds of the formula I, where R1 and R2 are each independently hydrogen, halogen, CN, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl or C1-C4-haloalkoxy, and R3 is C1-C4-alko...
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JP4399119B2 |
Methyl carbazate which is particularly pure and has a particularly low tendency toward discoloration is obtained from hydrazine and dimethyl carbonate if the two reactants are metered simultaneously into an initially introduced first sol...
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JP2009300434A |
To provide a method of reducing mortality associated with AIDS regarding the retroviral capsid protein of HIV-1.The method of reducing mortality associated with AIDS with a compound that binds to the apical cleft near the C-terminal end ...
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JP4387950B2 |
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JP4362517B2 |
The present invention relates to the isomerization of the Z-isomer I-Z of semicarbazone compounds of the general formula (I) into its E-isomer I-E, where the variables in formula (I) have meanings given in claim 1
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JP4338517B2 |
This invention relates to salts of guanidine derivatives of formula R-X-C(-NH)NH3+Z-, wherein X represents a valence bond, -CH2-NH-, -CH2-NH-NH- or -CH-N-NH-; R represents a linear or branched C1-C30 alkyl, C3-C20 cycloalkyl, adamantyl, ...
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JP2009533370A |
The present invention relates to novel intermediate products used in the method for producing 8-aryl-octanoyl derivatives, particularly chiral 8-aryl-octanoylamides and the above-mentioned methods for producing octanoyl derivatives, and ...
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JP4331751B2 |
The present invention discloses a fungicidally active compound of the formula: and a method for controlling fungi using the compound.
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JP4326837B2 |
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JP4326826B2 |
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JPWO2007122847A1 |
Reagents for organic synthesis and reagents that can carry out chemical reactions in the liquid phase and can easily and inexpensively separate unnecessary compounds from the liquid phase after completion of the reaction. Is to provide a...
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JP2009529488A |
Guanabenz compounds (I) are used to prepare medicaments for treating cystic fibrosis and diseases associated with protein addressing deficiency in cells. Guanabenz compounds of formula Ar-CH=N-NH-C(NH)-NH 2(I) or their salts are used to ...
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JP2009528282A |
The present invention provides a compound of the general formula 1, wherein X is the connection between the CO-hydrazine and the NR 1 -oxalic acid or ester group, and uses and synthesis methods. These compounds represent amino acid deriv...
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JP4306806B2 |
3-(Substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and ...
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JP4310284B2 |
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JP4267922B2 |
(R)-2-Arylpropionamide compounds of formula (I), pharmaceutical preparations of the compounds and a process for making the compounds are described. The 2-Arylpropionamides of the invention are useful in the prevention and treatment of ti...
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JP4266638B2 |
Novel PDF inhibitors and novel methods for their use are provided.
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JP4263200B2 |
A method for making a compound of Formula I which is racemic or enantiomerically enriched at chiral center* comprising hydrogenating a compound of Formula V in the presence of a compound of Formula VII wherein: R 1 is F, Cl, or C 1 -C 3 ...
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JP2009515830A |
Azodicarbonamide (ADA) in the form of a micronised dry powder, said powder having a granulometric distribution of particles wherein the particles of the powder have a mean diameter (d50) equal to or less than 2 mum and a 90% diameter (d9...
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JP4243101B2 |
A new and distinct hybrid of artichoke named ‘PS-H2015’, characterized by its numerous bud numbers, fleshiness of bracts, fleshiness of hearts, uniformity of head shapes; strong violet blush coloration; and ability to bolt in warm su...
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JP4242764B2 |
A method of effecting a nucleophilic substitution of an alcohol to produce a target product includes the steps of: reacting the alcohol and a nucleophile with an azodicarboxylate and a phosphine. At least one of the azodicarboxylate and ...
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JP2009502923A |
The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset o...
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JP4204069B2 |
PCT No. PCT/EP97/04166 Sec. 371 Date Jan. 29, 1999 Sec. 102(e) Date Jan. 29, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/05659 PCT Pub. Date Feb. 12, 1998Compounds of formula (3), and pharmaceutically acceptable salts and derivatives ...
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JP2008543960A |
Preparation of (hetero)aryl, ethers or thioether compound (III) comprises: cross-coupling of primary or secondary amines, alcohols or thioalcohols compound (II) with substituted (hetero)aryl compound (I) in the presence of Bronsted-base ...
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JP4167832B2 |
A method of synthesis of dinitro-diaza-alkanes and intermediate products thereto from alkylamines and esters, whereby a dialkyl ester of a dicarboxylic acid is reacted with an alkylamine in an aqueous medium to form the corresponding dia...
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JP4163254B2 |
PCT No. PCT/EP96/05874 Sec. 371 Date Dec. 4, 1998 Sec. 102(e) Date Dec. 4, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/25309 PCT Pub. Date Jul. 17, 1997Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and ...
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JP4127017B2 |
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JP4121497B2 |
The method for preparing hydrazodicarbonamide (HDCA) using biuret as a starting material is disclosed. The method comprises the steps of; obtaining metal monohalobiuret salt by reacting a biuret with a metal hypohalogen compound, or by r...
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JP4119842B2 |
The present invention relates to a method and apparatus for preparing hydrazodicarbonamide using urea as starting material economically and environmentally desirably. The apparatus includes a pyrolysis furnace to obtain biuret and ammoni...
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JP4105540B2 |
The invention relates to a highly active, highly specific urokinase inhibitor which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine deriva...
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JP4105241B2 |
A new chemical compound suitable for use as an explosive consists of guanylurea dinitramide having the formulawhich is also suitable as a main essential component for explosives, especially propellants; a pressed rocket motor charge; and...
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JP4094654B1 |
Provided is an industrially safe and useful azodicarboxylic acid bis(2-alkoxyethyl) ester compound that is useful for the Mitsunobu reaction in which it is used in combination with a phosphorus compound to carry out a dehydration condens...
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JP4091983B2 |
The subject of the invention is the products of formula (I):in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and t...
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JP2008513429A |
Compounds of formula (IIa): are provided where: X is a group capable of being cleaved from the alpha -carbon atom to form an ion of formula (I') C Ð is a carbon atom bearing a single positive charge or a single negative charge; The ...
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JP4073047B2 |
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JP4060386B2 |
Aminoalkylidene-hydrazine carboxylic acid esters are produced by reaction of a chloro-substituted hydrazine carboxylic acid ester with an amino compound. Production of aminoalkylidene-hydrazine carboxylic acid esters of formula (I) compr...
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JP4046722B2 |
To provide an industrially excellent method for producing a hydrazine compound where a load on the environment is reduced without by-producing any inorganic salts. The method for producing hydrated hydrazine or carbazic acid ester is cha...
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JP4033518B2 |
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