Acyclic or Carbocyclic Compounds

Matches 251 - 300 out of 1,858	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2004/110989A1	N-HYDROXY-7-(ARYLAMINO)HEPTANAMIDE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS This invention relates to novel N-hydroxy-7-(arylamino)heptanamide derivative compounds including salts, carbonates and O-acylated derivatives thereof, pharmaceutical compositions containing such compounds, and the use of those compounds...
WO/2004/099124A2	NOVEL BIOISOSTERES OF ACTINONIN The invention relates to novel bioisosteres of the antibiotic actinonin of general formula (I). Said novel compounds are of particular interest when used as inhibitors of metalloproteinases.
WO/2004/098582A2	KETONES AND REDUCED KETONES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds ...
WO/2004/092115A2	HYDROXAMATES AS THERAPEUTIC AGENTS The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associ...
WO/2004/087133A1	CRYSTALLINE N-FORMYL HYDROXYLAMINE COMPOUNDS Certain N-formyl hydroxylamine compounds, such as N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylami no-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes or imidazacycIo4-7alkanes are useful in the treatment of b...
WO/2004/076432A1	NEW AMIDE DERIVATIVES OF 2,2,3,3-TETRAMETHYLCYCLOPROPANE CARBOXYLIC ACID The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain.
WO/2004/071401A2	HYDROXAMIC ACID DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS (HDCA) A compound having the following formula (I): wherein R1 is lower alkyl optionally substituted with one or more suitable substituent(s); aryl optionally substituted with one or more suitable substituent(s); or fused ring, R2 is acylamino ...
WO/2004/069900A2	BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS Novel monoamidine, monoamidoxime and bisamidine curatives, co-curatives and cure accelerators are provided for use with perfluoroelastomeric compositions as well as novel synthesis methods for making monoamidine- and monoamidoxime-based ...
WO/2004/064727A2	METHOD OF CANCER TREATMENT USING HDAC INHIBITORS Improved methods for treatment of cancer are provided. The improvements include the administration of one or more synergistic agents, specifically inhibitors of histone deacetylase proteins and complexes. These synergistic agnets increas...
WO/2004/065354A1	CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS This invention pertains to certain carbamic acid compounds of the formula (I), which inhibit HDAC (histone deacetylase) activity: wherein: J is a linking functional group and is independently: -O-C(=O)- or -C(=O)-O- or - C(=O)-; Cy is a ...
WO/2004/062601A2	ANTIBACTERIAL AGENTS Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...
WO/2004/056746A1	CYCLOALKENE DICARBOXYLIC ACID COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein A is a non-aromatic ring system containing 4 to 8 carbon atoms, wherein the ring system comprises...
WO/2004/052919A2	PEPTIDE DEFORMYLASE INHIBITORS Novel PDF inhibitors and novel methods for their use are provided.
WO/2004/050620A2	DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula (I), useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass...
WO/2004/048335A2	MANDELIC ACID DERIVATIVES The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit ...
WO/2004/046104A2	TREATMENT OF LUNG CELLS WITH HISTONE DEACETYLASE INHIBITORS Lung disease, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma or acute and chronic bronchitis, can be treated with an oxyamide-containing compound.
WO/2004/046096A2	NOVEL LIGANDS THAT ARE ANTAGONISTS OF RAF RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS The invention relates to novel compounds corresponding to formula (I) below: and to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosm...
WO/2004/035533A1	NOVEL N-HYDROXY THIOUREA, UREA AND AMIDE COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME The present invention relates to novel n-hydroxythiourea, urea and amide compounds as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to ...
WO2000061134A9	ANTIMICROBIAL AGENTS Compounds of formula (I) are antibacterial agents wherein: Z represents a radical of formula -N(OH)CH(=O) of formula -C(=O)NH(OH) and R1-R4 are as defined in the specification.
WO/2004/033413A2	PROPARGYLETHER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE FOR CONTROLLING PHYTOPATHOGENIC MICROORGANISMS The invention relates to 4-propargyloxy-benzyl dervatives of the general formula (I ) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, optionally substituted alkyl, optionally substituted cycloa...
WO/2004/026824A1	PROCESS FOR PREPARING INTERMEDIATES The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors. The process makes use &agr β-lactam i...
WO/2004/024677A1	N-HYDROXYFORMAMIDINE DERIVATIVE An N-hydroxyformamidine derivative represented by the formula (I) wherein R1 represents hydrogen, C1-4 alkyl, C1-4 alkoxy, or halogeno; A represents C1-10 alkylene or a group represented by the formula (II) (wherein m, n, and p each is a...
WO/2004/022526A1	CATHEPSIN CYSTEINE PROTEASE INHIBITORS This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resor...
WO/2004/009536A1	NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS The present invention is directed to compounds of the general formula (I) or pharmaceutical acceptable salts or physiologically functional derivatives thereof wherein: n is a non-aromatic ring system containing two to seven carbon atoms,...
WO/2004/007449A1	PROCESS FOR CONVERSION OF PHENOLS TO CARBOXAMIDES VIA THE SUCCINIMIDE ESTERS A process for converting an aryl triflate, heteroaryl triflate, aryl halide or heteroaryl halide to an N-hydroxysuccinimido este is disclosed. The process involves reacting the triflate or halide with carbon monoxide and N-hydroxysuccini...
WO/2004/000792A1	A PROCESS FOR THE PREPARATION OF 3-CYANO-1-NAPHTHOIC ACID AND SOME ANALOGUES THEREOF The present invention is related to a process for the preparation of 3-cyano-1-naphthoic acid and some analogues thereof of formula (1), the intermediate 1-halo-3-cyano naphthalene and some analogues thereof used in this process and a pr...
WO/2004/000215A2	HYDROXAMATE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and 5-lipoxygenase (5-LO); as anticancer agents (...
WO/2003/101442A1	PEPTIDE DEFORMYLASE INHIBITORS Novel PDF inhibitors and novel methods for their use are provided.
WO/2003/099763A1	N-ACYLAMINOBENZENE DERVATIVES AS SELECTIVE MONOAMINE OXIDASE B INHIBITORS This invention relates to N-acylamino aryl derivatives of the general formula (I), wherein R1 is halogen, halogen-(C1-C6)-alkyl, cyano, C1-C6-alkoxy or halogen-(C1-C6)-alkoxy; R21, R22, R23 and R24 independently from each other are selec...
WO/2003/099769A1	ANILINO LIVER X-RECEPTOR MODULATORS The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically ...
WO/2003/086316A2	DEGRADABLE CROSSLINKERS, AND DEGRADABLE CROSSLINKED HYDROGELS COMPRISING THEM One aspect of the present invention relates to base−labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base−labile crosslinker. The present invention al...
WO/2003/087066A1	&agr ,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents b...
WO/2003/075839A2	METHODS OF INDUCING TERMINAL DIFFERENTIATION The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositio...
WO/2003/076395A1	CARBONYLAMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE This invention comprises the novel compounds of formula (I)wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing th...
WO/2003/075836A2	CATHEPSIN CYSTEINE PROTEASE INHIBITORS This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bo...
WO/2003/074476A1	NOVEL ARYLAMIDINE DERIVATIVE OR SALT THEREOF An arylamidine derivative represented by the general formula (1) (wherein X means optionally substituted lower alkylene or alkenylene; G1 means oxygen, sulfur, or imino; G2 means carbon or nitrogen; Ra means at least one member selected ...
WO/2003/070690A2	NOVEL AMINO ACID DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVE The invention relates to compounds of formula (I): where R1 = an aryl, heteroaryl or alkyl group, optionally substituted with a group of formula -(CO)-CR6R7NR8R9, where R6, R7, R8 and R9 are as defined in the description, R2 = H or optio...
WO/2003/070691A1	N-HYDROXYCARBOXAMIDE DERIVATIVE It is intended to provide a novel N-hydroxycarboxamide derivative which is excellent in physical properties such as stability and dissolution properties and a potent histone deacetylase (HDAC) inhibitory activity. It is found out that a ...
WO/2003/066579A2	NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical c...
WO/2003/066889A2	ASSAY FOR ACYTYLTRANSFERASE OR DEACETYLASE ACTIVITY This invention is directed to a continuous method for measuring the activity of an enzyme that catalyzes the addition of an acetyl group to a residue capable of being acetylated or an enzyme that catalyzes the removal of an acetyl group ...
WO/2003/062191A1	N-(4-SUBSTITUTED PHENYL)-ANTHRANILIC ACID HYDROXAMATE ESTERS The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
WO/2003/057664A1	CARBOXAMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF VASCULAR DISEASES The invention relates to carboxamidine derivatives to pharmaceutical compositions containing the same and the use thereof in the preparation of pharmaceutical compositions for the treatment of vascular diseases.
WO/2003/053915A2	COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS This invention relates to compounds of the Formula (I):(Chemical formula should be inserted here as it appears on abstract in paper form)(I)or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the tre...
WO/2003/049690A2	HIV INTEGRASE INHIBITORS The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the following formula, or a tautomer of said compound, or a pharmaceutically acceptable salt, solvate or ...
WO/2003/048114A2	BACTERIAL ENZYME INHIBITORS Compounds of formula (I), are antibacterial agents, wherein: Z represents a radical of formula -N(OH)CH(=O) or of formula -C(=O)NH(OH); X represents a straight or branched divalent C¿1?-C¿6? alkylene, C¿2?-C¿6? alkenylene, or C¿2?-C...
WO/2003/042150A1	NOVEL BENSOPHENONE DERIVATIVES OR SALTS THEREOF Because of having an anti−arthritic effect, inhibiting bone fracture induced by arthritis and having a high safety, benzophenone derivatives represented by the following general formula or salts thereof are useful as remedies for arthr...
WO/2003/024390A2	HYDROXYEICOSENOIC ACID ANALOGS A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond $m(Z) represents a cis-vinylene group or an ethynylene group; Y represents CH?2¿, O or S(O)?p¿ wherein p is 0, 1 or 2; m represents an integer of 1 to 4...
WO/2003/024922A1	HYDROXYFATTYSULFONIC ACID ANALOGS A hydroxyfattysulfonic acid analog represented by Formula (I): wherein X is an ethylene group, a vinylene group or an ethynylene group; Y is an ethylene group, a vinylene group, an ethynylene group, OCH¿2? or S(O)pCH¿2? wherein p is 0,...
WO/2003/022810A1	3-AMINO CARBONYL-SUBSTITUTED BENZOYLCYCLOHEXANEDIONES THAT CAN BE USED AS HERBICIDES The invention relates to derivatives of benzoylcyclohexanediones of formula (I) and to their use as herbicides. In general formula (I): R?1a¿, R?1b¿, R?1c¿, R?2¿, R?3¿, R?4¿ and R?5¿ represent different radicals; X?1¿ represents ...
WO/2003/011851A2	AROMATIC HYDROXAMIC ACID DERIVATIVES USEFUL AS HDAC INHIBITORS Compounds of formula (I) wherein A, R¿1? and R¿2? have the meanings defined in the specification, process of manufacturing these compounds and medicaments with HDAC inhibitor activity containing such a compound.

Matches 251 - 300 out of 1,858	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >