Acyclic or Carbocyclic Compounds

Matches 551 - 600 out of 1,858	< 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >

Document	Document Title
WO/1997/006133A1	HYDROXIMIC ACID DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS PESTICIDES AND FUNGICIDES Hydroximic acid derivatives have the formula (I), in which the substituents have the following meanings: X stands for CH, CHO or NO; Y stands for O or NH; Z stands for O, S or NRa; Ra stands for hydrogen, alkyl, alkenyl or alkinyl; R1 st...
WO/1997/005105A1	N-(AROYL)GLYCINE HYDROXAMIC ACID DERIVATIVES AND RELATED COMPOUNDS Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are useful in the...
WO/1997/003966A1	N-(AMINO ACID) SUBSTITUTED SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS Compounds selected from the group consisting of 2,N1-dihydroxy-3-isobutyl-N4-[2-methoxy-2-methyl-1-(pyridin- 2-yl-carbamoyl)-propyl]-succinamide, N1-(2-fluoro-2-methyl-1-methylcarbamoyl-propyl)-N4-hydroxy-2 -isobutyl-3-methoxy-succinamid...
WO/1997/002239A1	MATRIX METALLOPROTEINASE INHIBITORS Compounds of formula (I), wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 12 C atoms and R6 represents hydrogen or an optionally substituted ar...
WO/1997/002237A1	FLUOROBUTENIC ACID OXIME ESTERS The invention pertains to fluorobutenic acid oxime esters of formula (I) CF2=CX-CH2-CO-ON=CR1R2 in which: X stands for hydrogen or halogen; R1 and R2 independently of one another stand for hydrogen or (in each case optionally substituted...
WO/1997/001532A1	KETONITRILE DERIVATIVES AND ANTIBACTERIAL AGENT AND DRUG CONTAINING THE SAME A ketonitrile derivative represented by general formula (1) or a salt thereof and an antibacterial agent and a drug containing the same, wherein R1 represents hydrogen or lower alkyl; R2, R3, R4 and R5 are the same or different and each ...
WO/1996/040662A2	AMINOOXY-CONTAINING LINKER COMPOUNDS AND THEIR APPLICATION IN CONJUGATES Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are aminooxy-containing linker compounds useful in forming conjugates having stable oxime linkages. The stably-linked conjugates have utility...
WO/1996/040623A1	2-SUBSTITUTED 1,8-DIHYDROXY-9(10H)-ANTRACENONE AS PROLIFERATION AND 5-LIPOXYGENASE INHIBITORS 2-substituted 1,8-dihydroxy-9(10H)-antrhacenones of general formula (I), therapeutic compositions containing at least one 2-substituted 1,8-dihydroxy-9(10H)-anthracenone compound and methods of treating inflammatory conditions especially...
WO/1996/037464A1	SUBSTITUTED 'beta'-AMINO ACID DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS Novel substituted amino acid derivatives are provided which inhibit platelet aggregation and which are useful in pharmaceutical compositions and methods of inhibiting platelet aggregation.
WO/1996/034851A1	BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using t...
WO/1996/034850A1	CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using the compounds of the in...
WO/1996/033968A1	HIGHLY WATER-SOLUBLE METALLOPROTEINASE INHIBITOR Novel compounds represented by general formula (I), stereoisomers thereof, pharmaceutically acceptable salts, and solvates thereof, processes for the preparation thereof, a matrix metalloproteinase inhibitor comprising as the active ingr...
WO/1996/033166A1	HYDROXAMIC AND CARBOXYLIC ACIDS AS METALLOPROTEASE INHIBITORS The present invention provides hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these compounds for the inhibition of matrix metalloproteinases, such as stromelysin, ...
WO/1996/033164A1	NEW HYDROXIMIC ACID DERIVATIVES Hydroximic acid derivatives of general formula (I), wherein G is either G1 or G2 or G3 or G4 of the formula: R5OC=C(COOR4)-, R5ON=C(COOR4)-, R5ON=C(CONR6R7)-, R5OC=C(CONR6R7)-, X1, X2, X3 are H, halo, HO, mercapto, nitro, SCN, azido, CN,...
WO/1996/033160A1	DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION The present invention provides dihalopropene compounds of general formula (I), wherein R1 is C1-C10 alkyl or the like; L is C(=O)NH or the like; R2, R3 and R4 are independently halogen or the like; R5, R6 and R7 are independently hydroge...
WO/1996/033161A1	DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITORS Compounds of formula (I), wherein X is a -CO2H or -CONHOH group; R4 is a group -CHRxRy wherein Rx and Ry independently represent optionally substituted phenyl or monocyclic heteroaryl rings, which optionally may be linked covalently to e...
WO/1996/033176A1	NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrixmetalloproteinases, such as st...
WO/1996/033165A1	DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR Compounds of formula (I), wherein X is a -CO2H or -CONHOH group; R4 is a group -CHRxRy wherein Rx and Ry independently represent optionally substituted phenyl or monocyclic heteroaryl rings, which optionally may be linked covalently to e...
WO/1996/031461A1	PHENOXYETHYLAMINE DERIVATIVES HAVING HIGH AFFINITY FOR THE 5-HT1A RECEPTOR, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretio...
WO/1996/030036A1	COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are pr...
WO/1996/030381A1	IMMUNOSUPPRESSIVE AGENTS Amino amide derivatives of general formula (I), wherein R1 is hydrogen or C1-3-alkyl, optionally substituted with hydroxy, R2 is hydrogen, straight or branched C1-6-alkyl, or straight or branched C1-6-alkyl, mono-, di- or trisubstituted ...
WO/1996/026918A1	SYNTHESIS OF CARBOXYLIC AND HYDROXAMIC ACID DERIVATIVES A method for the preparation of carboxylic and hydroxamic acid derivatives by cocondensation in a liquid organic medium of three reaction components, namely a carboxylic acid reaction component of formula (II), an imine reaction componen...
WO/1996/025398A1	SUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS FUNGICIDES The invention relates to novel substituted heterocyclic compounds, several processes for their production and their use as fungicides, and novel intermediate products, several processes for their production and their use as fungicides.
WO/1996/020918A1	HYDROXAMIC ACID-CONTAINING INHIBITORS OF MATRIX METALLOPROTEASES The invention provides hydroxamic acid-containing compounds which are useful as inhibitors of matrix metalloproteases and which are effective in treating conditions associated with excess activity of these enzymes. In particular, the pre...
WO/1996/019442A1	BENZAMIDOXIME DERIVATIVE, PROCESS FOR PRODUCTION THEREOF, AND AGROHORTICULTURAL BACTERICIDE A benzamidoxime derivative having an excellent bactericidal activity, being useful as an agrohorticultural bactericide, and represented by general formula (I) wherein R1 represents C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, each of whi...
WO/1996/019441A1	METHOD FOR PREPARING DESFERRIOXAMINE B AND HOMOLOGS THEREOF A new and versatile route to N'-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobut yl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxybutanedia mide, desferrioxamine B (DFO) is described. N-Benzyloxy-1,5-diaminopentane is selectiv...
WO/1996/017838A1	MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS There is described the use of a compound represented by general formulae (I), (II) or (III), for the inhibition of matrix metalloproteinases (MMP), wherein X1 is oxygen or sulfur, R1 is OH, SH, CH2OH, CH2SH or NHOH, R2 is a residue of 2 ...
WO/1996/016679A1	PARAMAGNETIC COMPLEXES OF N-ALKYL-N-HYDROXYLAMIDES OF ORGANIC ACIDS AND EMULSIONS CONTAINING SAME FOR MAGNETIC RESONANCE IMAGING (MRI) Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic acid chelator, for example DTPA ...
WO/1996/016931A1	METALLOPROTEINASE INHIBITORS Compounds of general formula (I), principally characterized in that R4 is a polyether group, are water soluble matrix metalloproteinase inhibitors.
WO/1996/016030A1	IMINOOXYMETHYLENE ANILIDES, PROCESS AND INTERMEDIATE PRODUCTS FOR PREPARING THE SAME AND PESTICIDES CONTAINING THE SAME Iminooxymethylene anilides have the formula (I), in which the substituents and indices have the following meanings: R stands for hydrogen, optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkinyl, alkylcarbo...
WO/1996/016027A1	MATRIX METALLOPROTEASE INHIBITORS Compounds of formula (I) and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as stromelysin, gelatinase, matrilysin and collagenase, and are useful in the treatment of mammals having disease-states alleviate...
WO/1996/016029A1	2-(4-BIPHENYL-OXYMETHYLENE)ANILIDES, PROCESS AND INTERMEDIATE PRODUCTS FOR PREPARING THE SAME AND THEIR USE AS PESTICIDES 2-[4-biphenyl-oxymethylene]-anilides have the formula (I), in which the indices and substituents have the following meanings: R, R1, R2 stand for cyano, nitro, halogen, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkylthio hal...
WO/1996/013509A1	FLUOROALKENYL COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS Fluorinated alkene compounds having structure (I) wherein Q is -(C=S)-R1, -(C=W)-R2, or -(P=W)R3R4; wherein W is O or S; and R1 to R4 are as defined in claim 1; are useful for controlling nematodes, insects, and acarids that prey on agri...
WO/1996/006822A1	ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF The present invention relates to compounds of formula (I) wherein: A is an optionally substituted ring system as defined herein; B is an optionally substituted 5- or 6-membered heteroaryl ring system or optionally substituted phenyl; D i...
WO/1996/006074A1	METALLOPROTEINASE INHIBITORS Compounds of formula (I) principally characterised in that R4 is an optionally substituted C3-C8 cycloalkyl group or optionally substituted C4-C8 cycloalkenyl group are inhibitors of matrix metalloproteinases.
WO/1996/004253A1	PROCESSES AND INTERMEDIATES IN THE SYNTHESIS OF 5-(3-[EXO-BICYCLO[2.2.1]HEPT-2-YLOXY]-4-METHOXYPHENYL)-3,4,5,6-TETRAHYDROPYRIMID IN-2(1H)-ONE This invention relates to novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)- 3,4,5,6-tetrahydropyrimidin-2(1H)-one and its corresponding 2R enantiomer and for p...
WO/1996/004239A1	N-ALKOXY-AMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES New N-alkoxy-amidine derivatives having the formula (I) are disclosed, as well as a process for preparing the same and their use as pesticides. Also disclosed are new intermediate products and a process for preparing the same.
WO/1996/002518A1	SUBSTITUTED CINNAMIC OXIME AND HYDROXAMIDE DERIVATIVES Substituted cinnamic oxime derivatives (I) and hydroxamide derivatives (II) (formulae I and II) where R1 = halogen, NO2, CN, CF3; R2 = H, halogen; R3 = H, halogen, C1-C6 alkyl halide, C3-C6 alkenyl, C3-C6 alkinyl, hydroxy-C1-C4 alkyl; R4...
WO/1996/002497A1	SUBSTITUTED BENZAMIDINES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS The novel compounds of formula (I) (the meanings of A and R1 to R4 are given in the description) may be produced by conventional methods and therapeutically used as, for example, LTB4 antagonists.
WO/1995/035275A1	METALLOPROTEINASE INHIBITORS Compounds of general formula (II) wherein X is a hydroxamic or carboxylic acid group, Y is carbonyl or sulphonyl and R1 and R2 are as defined in the claims, are matrix metalloproteinase inhibitors.
WO/1995/035276A1	METALLOPROTEINASE INHIBITORS Compounds of general formula (II), wherein X is a hydroxamic or carboxylic acid group, Y is sulphonyl and R1 and R2 as defined in the claims are matrix metalloproteinase inhibitors.
WO/1995/033709A1	HYDROXYLAMINE DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS The invention provides hydroxylamine derivatives of formula (I) wherein A, R1, R2 and R3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. They are therefore...
WO/1995/032944A1	SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS Compounds of general formula (I) wherein X is a -CO2H, -N(OH)CHO or -CONHOH group; R1 is hydrogen; (C1-C6)alkyl; (C2-C6)alkenyl; phenyl; substituted phenyl; phenyl(C1-C6)alkyl; substituted phenyl(C1-C6)alkyl; heterocyclyl; substituted he...
WO/1995/031977A1	NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHODS OF USE THEREOF The present invention provides the compound having structure (I), wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloa...
WO/1995/032184A1	SYSTEMATIC MODULAR PRODUCTION OF AMINIMIDE- AND OXAZOLONE- BASED MOLECULES HAVING AT LEAST TWO STRUCTURAL DIVERSITY ELEMENTS Aminimide- and oxazolone-based molecules, and arrays thereof, having at least two structural diversity elements are made via systematic modular production. A combinatorial library of aminimide- and oxazolone-based molecules is made via s...
WO/1995/030644A1	AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE Novel carbocyclic amides together with their salts, solvates and physiologically active derivatives which have a number of uses in medicine, in particular as central muscle relaxants, and in the treatment or prophylaxis of anxiety, infla...
WO/1995/030649A1	NOVEL HYDROXIMIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME The invention relates to novel compounds of formula (I), wherein X means halogen; Z stands for an aromatic group, pyridinyl group or the like; and R represents an alkyl or phenylalkyl group or an -A-N(R1)R2 group, and in the latter R1 an...
WO/1995/029889A1	PERHALOALKOXYBENZENOPHENONE HYDRAZONES AND THEIR USE AS PESTICIDES Compounds of formula (I) in which X is (a) or (b), n is 0, 1, 2, 3, 4 or 5, where if n is greater than 1, the radicals R2 are identical or different; o is 0, 1, 2, 3 or 4, where if o is greater than 1, the radicals R3 are identical or di...
WO/1995/024383A1	OXIME DERIVATIVES AND THEIR USE AS PESTICIDES New oxime derivatives are disclosed, as well as several processes for preparing the same and their use as pesticides.
WO/1995/024382A1	L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS There is disclosed a novel amino glycol derivatives of L-N6-(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.

Matches 551 - 600 out of 1,858	< 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >