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WO/2001/062735A1 |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula (I), wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicat...
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WO/2001/057947A1 |
The invention relates to amidines of perfluorinated C2-C5 carboxylic acids, which can be used as solvents or components of solvents for conducting salts in electrolytes. Some new amidines are also disclosed.
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WO/2001/055146A1 |
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a phar...
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WO/2001/055175A2 |
The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalanin
amides of formula (I), in which the anions X are physiologically acceptable anions, and their analogs, which a...
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WO/2001/055095A1 |
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...
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WO/2001/044164A1 |
The invention relates to substituted norbornylamino derivatives containing exo-configured nitrogen and an endo-annellated pentacyclic ring of formula (I) and exo-configured nitrogen and an exo-annellated pentacyclic ring of formula (Ia),...
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WO/2001/044172A1 |
The present invention provides novel compounds of Formula (I), its prodrug forms, or pharmaceutically acceptable salts thereof. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or ...
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WO/2001/042198A2 |
Novel process steps and novel processes for producing unsubstituted and substituted meta- and para- cyano benzoic acid compounds, as well as salts and derivatives thereof, and intermediates therefor which are useful as intermediates for ...
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WO/2001/042199A1 |
An amidinophenylpyruvic acid derivative represented by the following formula, its analogs and pharmaceutically acceptable salts thereof which have an excellent effect of inhibiting activated blood coagulation factor VII.
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WO/2001/036374A2 |
The invention relates to bis-basic compounds of the general formula (I): B?1¿-Ar?1¿-X?1¿-Ar?2¿-X?2¿-A-X?3¿-Ar?3¿-X?4¿-Ar?4¿-
B?2¿, wherein the groups B?1¿, B?2¿, Ar?1¿, Ar?2¿, Ar?3¿, Ar?4¿, X?1¿, X?2¿, X?3¿, X?4¿ and ...
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WO/2001/036381A1 |
Hydrazone compounds represented by general formula (1) or salts thereof and novel agricultural chemicals (in particular, insecticides and miticides) containing these compounds as the active ingredient formulae (1), G-1, G-2, G-3, wherein...
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WO/2001/036371A1 |
There are described new compounds of formula (I) wherein, when n is 0, at least one of the two phenyl rings is substituted; R¿1? and R¿2? are each independently of the other hydrogen, halogen, cyano, nitro, C¿1-4?alkyl, C¿1-4?haloalk...
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WO/2001/030148A1 |
This invention relates to novel substituted succinic acid metallo-$g(b)-lactamase inhibitors which are useful potentiators of $g(b)-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections...
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WO/2001/027092A2 |
A process is described for preparing 1-aryltriazolinones of formula (I) useful in the production of commercial herbicides, by: i) carbonylating an amidrazone of formula (A) with one or more carbonylating agent, or ii) condensing a hydraz...
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WO/2001/025186A1 |
The invention relates to a novel LTB¿4? antagonist, to a method for the production thereof and to its use as a medicament.
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WO/2001/021592A1 |
The invention provides novel processes for preparing efficiently compounds of general formula (I) (wherein R¿1? and R¿2? are each independently hydrogen, optionally substituted C¿1?-C¿10? alkyl, C¿3?-C¿14? hydrocarbyl bearing an al...
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WO/2001/021582A1 |
The invention relates to compounds of the formula (I), wherein X, R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ have the meaning indicated in claim 1. The inventive compounds represent inhibitors of the subtype 3 sodium/proton exchanger (NHE-3).
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WO/2001/014320A1 |
The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of tryptase and for the treatment and/or prevention ...
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WO/2001/010823A1 |
The invention relates to carboxylic acid amides of formula (I), wherein R¿1? to R¿5?, Ar, m and n are defined in Claim 1, their tautomers, their stereoisomers, their mixtures, their prodrugs and their salts, which exhibit valuable prop...
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WO/2001/005753A1 |
Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R?1¿, R?2¿ and R?3¿ have the meanings cited in Claim 1, and the physiologically acceptable salts or solvates thereof, which are integrin inhibitors and can be used to...
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WO/2001/005748A1 |
The current invention discloses novel oligomeric amidino aminocarboxylate derivatves useful as nitric oxide synthase inhibitors.
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WO/2001/000623A1 |
Method of producing compounds of formula (I), wherein R¿1? is hydrogen or C¿1?-C¿4?-alkyl; R¿2? is hydrogen, C¿1?-C¿8?-alkyl, C¿3?-C¿6?-cycloalkyl, or a radical -N(R¿3?)R¿4?; or R¿2? and R¿6? together are -CH¿2?-CH¿2?-S-; R...
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WO/2000/069813A1 |
The invention relates to novel substituted N-cyano amidines of general formula (I) in which: R?1¿ represents hydrogen or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or alkyl aryl, and; R?2¿ represe...
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WO/2000/067751A1 |
Compounds represented by formula (I): or a pharmaceutically acceptable salt or hydrate thereof, are disclosed. Pharmaceutical compositions and methods of treatment are also included.
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WO/2000/066587A2 |
Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. A...
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WO/2000/066545A1 |
The invention concerns compounds of general formula (I) wherein: R¿1? represents either a hydrogen atom, or an amino group, or a C¿1?-C¿4? alkyl group, or a C¿1?-C¿6? alkoxycarbonyl group, or a -OH group; R¿2? represents either a C...
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WO/2000/053586A1 |
The invention relates to the use of formamidine salts of the general formula (I): (NH¿2?-CH=NH¿2?)¿n?H¿x-n?Y, where Y is SO¿4?, x is 2 and n is between 0.1 and 2.0, or Y is PO¿4?, x is 3 and n is between 0.1 and 3.0. The salts obta...
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WO/2000/047554A2 |
Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubs...
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WO/2000/047553A2 |
Alkenyl and alkynyl compounds as potent and highly selective inhibitors of factor Xa isolated or assembled in the prothrombinase complex and compositions containing such alkenyl and alkynyl compounds are described. Such compounds show se...
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WO/2000/046184A1 |
The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R?1¿ is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R?2¿ and R?3¿, which may be the same or...
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WO/2000/044731A1 |
The current invention discloses novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors. Compounds of particular interest are defined by Formula (I) wherein X, Y, A, J, R?1¿, R?2¿ R?3¿, R?4¿, R?7¿ and...
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WO/2000/042000A1 |
The invention concerns a method for preparing an azoiminoether hydrochloride which consists in reacting an azonitrile with an alcohol and hydrochloric acid in an aromatic solvent, wherein the molar ratio R = HCl/azonitrile is > 2 when th...
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WO/2000/041531A2 |
Compounds having structure (A) are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
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WO/2000/040529A1 |
The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C=NOH, or -CH(R?7¿)- wherein R?7¿ is hydrogen, hydroxy, C¿1-7?alkoxy, -OR?8¿ or -NR?8¿R?9¿ (wherein R?8¿ is a group -Y?1¿R?10¿ (wherein ...
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WO/2000/040571A1 |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of formula (I), wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated i...
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WO/2000/040548A1 |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to arylalkanoyl derivatives of formula (I), wherein R(1), R(2), R(3), R(4), R(5), R(6a) and R(6b) have the meanings indi...
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WO/2000/035858A1 |
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I), wherein R?1¿, E, X?1¿ to X?4¿ and G?1¿ and G?2¿ are as defined in the description and the claims, as well as hydrates or solvates a...
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WO/2000/035859A1 |
The invention relates to new substituted aryl and heteroaryl derivatives of the general formula (I) Ar - A - HCR¿1? - X - Y, in which A, Ar, X, Y and R¿1? have the meanings given in claim 1, and to their tautomers, stereoisomers, mixtu...
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WO/2000/031082A1 |
Novel pyrimidine derivatives of formula (I), as well as possible isomers and mixtures of isomers thereof. The novel compounds have plant-protective properties and are suitable for protecting plants against infestations by phytopathogenic...
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WO/2000/027790A1 |
A compound of formula (IA) or (IB): in which R?1¿ is R?A¿(CH¿2?)¿n?O(CH¿2?)¿m?, R?A¿(CH¿2?)¿p?, Formula (II) or in which R is a spiro-fused mono- or bi-cyclic ring containing one or two basic nitrogen atoms; and X?1¿ and X?2¿,...
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WO/2000/017156A1 |
The invention relates to benzamidoxime derivatives of formula (I), whereby the substituents have the following meanings: R?1¿ represents difluoromethyl or trifluoromethyl; R?2¿ represents hydrogen or fluorine; R?3¿ represents C¿1?-CÂ...
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WO/2000/016766A1 |
A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by formula (I) wherein R?1¿ is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or h...
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WO/2000/006620A2 |
Various olefins may be polymerized using a catalyst system containing selected $g(a)-diimine, urethane or urea ligands, some of them novel, complexed to nickel, palladium or other selected transition metals. The polymers are useful as mo...
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WO/2000/006555A1 |
This invention provides a process for preparing compounds of formula (1) wherein: X is phenyl optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 ca...
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WO/2000/003975A2 |
The invention relates to aryl vinyl ether derivatives of general formula (I), wherein the substituents are as defined in the description; compositions containing them, processes and intermediates for their preparation and a method of con...
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WO/1999/067203A1 |
Compounds of general formula (I) wherein A is (a) or (b); Z is (CH¿2?)¿m? or a carbonyl group are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions compris...
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WO/1999/064392A1 |
A benzamidine derivative represented by formula (I), analogs thereof and pharmaceutically acceptable salts thereof. Because of having an effect of inhibiting activated blood coagulation factor X, these compounds are useful as preventives...
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WO/1999/062968A1 |
Methods for preparing olefin polymers, and catalysts for preparing olefin polymers are disclosed. The polymers can be prepared by contacting the corresponding monomers with a Group 8-10 transition metal catalyst and a solid support. The ...
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WO/1999/057096A1 |
The invention relates to novel compounds of formula (I), wherein X, R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ have the meanings cited in Patent Claim No. 1. Said compounds are inhibitors of the coagulation factor Xa and can be used for prophy...
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WO/1999/046240A2 |
Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors of Formula (I) or a pharmaceutically acceptable salt thereof, wherein all substituents are described in the specification.
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