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JP2009004374A |
To provide a proton conductor which has a melting point lower than room temperature and a low vapor pressure and a similar conductivity with what can be obtained in an aqueous medium.The proton conductor of a liquid form contains a mixtu...
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JP4202438B2 |
Amidine derivs. of formula R3-NH-C(=NR1)-R-COR2 (I) and their salts are new. R = -Q-B-Q1-(CH2)n-, -Q-CH2-O-Phe-(CH2)p-, -Q-CH2-O-Phe-CH2-CH(NHR4)-, -Phe-NHCOCH2CH2CONHCHR5CH2-, -Phe-Q2(CH2)k-Q3-(CH2)l-, -Phe-CO-AA-Q4-OCH2-, -Phe-Phe-OCH2...
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JP2008542267A |
The present invention relates to methods for preparing substituted 3-cyanoquinolines and intermediates obtained by the methods of the present invention. The methods of the invention comprise reacting an N-aryl-2-propanimide with phosphor...
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JP4186182B2 |
A insecticide comprises a hydrazone derivative (I). An insecticide comprises a hydrazone derivative of formula (I). [Image] A, Q : aryl or heteroaryl (both optionally substituted); W : O, aminilene (optionally substituted), alkylene, oxy...
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JP4180375B2 |
Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders
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JP2008266327A |
To provide a compound having an inhibition function against osteoporosis and relating bone texture loss.This compound has Src kinase inhibiting function and is either one of an amide having a general structure represented by formula (II)...
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JP2004509099A5 |
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JP2008231092A |
To povide novel dicationic teraryl compound and its aza analogue, a method for combating microbial infections with the compound, and a process for synthesizing the compound.As the novel dicationic teraryl compound, for example, a compoun...
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JP2008214353A |
To provide a polyethylene glycolated (PEGylated) ion channel modulating compound that meets the requirement of identification of new antiarrhythmic treatment in both of ventricular arrhythmia and atrial arrhythmia.This invention is a PEG...
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JP4150427B2 |
Benzamidine derivatives of formula (I), and their salts, are new: A =O(2-4C alkylene)O or (1-3C alkylene)O; R1 = 1-6C alkyl or halo; R2 = H, 1-6C alkyl or halo; R3, R4 = H, 1-6C alkyl, 1-6C alkoxy, OH, CF3; or R3+R4 = part of a condensed...
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JP2008536800A |
This invention relates to processes for the production of organometallic compounds represented by the formula M(L)3 wherein M is a Group VIII metal, e.g., ruthenium, and L is the same or different and represents a substituted or unsubsti...
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JP2008179653A |
To satisfy demands for identification of a new treatment on anti-arrhythmia on both of the venticular arrhythmia and atrial arrhythmia.The invention relates to PEGlyated derivatives comprising one or more PEG moieties attached to an ion ...
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JP4125782B2 |
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to tr...
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JP4124487B2 |
Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
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JP4107687B2 |
The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula I herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical comp...
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JP4106337B2 |
Amino acid amide compounds (I), are new. Amino acid amide compounds of formula (I), their optical isomers and acid addition salts are new. R1 = aryl, heteroaryl, 1-6C alkyl (optionally substituted by at least one aryl or heteroaryl), or ...
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JP2008520569A |
Disclosed are prodrugs of (2R)-2-propyloctanoic acid, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke. Also disclosed are methods of treating pati...
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JP4103147B2 |
Benzamidine derivatives of the following formulae or analogs thereof, i. e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effec...
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JP4104984B2 |
Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, R1 is selected from an alkyl group ha...
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JPWO2006070878A1 |
Provided is a compound which has an anticoagulant action based on the inhibition of activated blood coagulation factor VII and is useful as a blood coagulation inhibitor or a prophylactic / therapeutic agent for a disease caused by throm...
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JP4092739B2 |
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JP4088703B2 |
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JP2008512364A |
The invention is concerned with novel 4-aminomethyl benzamidine derivatives of formula (I) wherein Ar and X are as defined in the description and in the claims, as well as prodrugs and pharmaceutically acceptable salts thereof These comp...
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JP4081138B2 |
This invention relates to thrombin inhibiting compounds haveing the Formula I X-Y-NH-(CH2)r-G where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods o...
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JP4070244B2 |
Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
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JP2008050361A |
To provide pharmaceuticals in treating or preventing a disease or condition in which cannobinoid receptor activation plays a role.The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)2, S(O)2...
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JP2008505900A |
Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kina...
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JP4053597B2 |
Compounds of the formula:
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JP4042423B2 |
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JP2008502680A |
Copper (I) amidinate precursors for forming copper thin films in the manufacture of semiconductor devices, and a method of depositing the copper (I) amidinate precursors on substrates using chemical vapor deposition or atomic layer depos...
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JP2008013533A |
To provide a novel compound containing plural complexes which enables simple and easy synthesis of a large amount of a cluster having a controlled size and a metal complex which can be used for the synthesis of this compound, and a metho...
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JP2008007781A |
To graft a polymer at the surface of a carbonated material containing carboxyl, amine and/or hydroxyl functions at its surface.The carbonated material is suspended in a solution comprising the polymer to be grafted, which includes the ca...
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JP2008001719A |
To provide methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD).The invention relates to methods for the pro...
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JP2007320930A |
To provide an industrial production method by which phenyltetrazole derivatives (7) and (8) useful as intermediates for synthesizing pharmaceutical compounds can be produced in safe and mild conditions at low costs. In this production me...
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JP2007529541A |
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation...
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JP2007261250A |
To provide a thermosensitive recording body with a high whiteness degree of white paper parts, a high color developing concentration, and high oil resistance. The thermosensitive recording body comprises a sheet shape base body and a the...
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JP2007521237A |
Novel amidine and diamidine compounds are useful in the treatment of microbial infections, including mycobacterial, fungal and protozoal infections. Pharmaceutical formulations comprising these compounds can be used in methods of treatin...
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JP2007518786A |
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising adm...
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JP2007516290A |
The present invention provides compounds, which, are novel antagonists for D1 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1 recepto...
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JP2007513888A |
Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum. Prodrugs of these compounds can be used as an oral t...
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JP2007513117A |
Use of compounds of formula I wherein Q is X1 is chlorine, bromine, or fluorine; R1, R2 are each independently H, alkyl, alkenyl, alkynyl, or cycloalkyl, alkylamino, dialkylamino, alkylcarbonylamino, alkylsulfonyl, or alkylsulfinyl, wher...
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JP3919227B2 |
Novel amidine derivatives of the formula (1); and drug carriers such as liposomes or emulsions comprising the derivatives, which can enclose genetic materials or drugs and transfer them to cells or affected sites efficiently and safely,w...
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JP2007091657A |
To provide a novel amidine derivative, its salt, and its use.The novel amidine derivative is represented by general formula (1) (wherein A is an aromatic ring; R1 and R2 are each independently a 10-20C alkyl or alkenyl group; X is O or N...
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JP2007070230A |
To provide a method for simply manufacturing an azobis amidino compound hydrochloric acid salt of high grade.The manufacturing method of the azobis amidino compound hydrochloric acid salt comprises a step of dissolving a crude azobis-ami...
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JP3875263B2 |
An alpha -substituted phenylacetic acid derivative useful as an agricultural fungicide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricultu...
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JP2007001986A |
To provide a new method for producing 2-methylcysteine at a rational cost as a precursor for desferrithiocin and related compound exhibiting advantage for the iron chelating therapy of an examinee affected by ion overload owing to the me...
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JP2006335759A |
To provide a linear dication terphenyl and an aza analogue thereof as a vermicide, for the purpose of controlling microbial infectious disease.The new dication terphenyl compound and the aza analogue thereof are provided, respectively. F...
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JP2006328034A |
To provide a new transition metal complex relatively stable and easy to handle, and usable in a highly active catalyst for cyclic olefin polymerization, to provide a cyclic olefin polymerization catalyst containing the above transition m...
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JP2006527776A |
Provided are MC4-R binding compounds of the formula XVII: wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated d...
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JP3853653B2 |
The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1 , the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable p...
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