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Patent Searching and Data


Matches 101 - 150 out of 15,344

Document Document Title
WO/2023/139581A1
Compounds represented by Formula I: (I) wherein A, B, W, V, Z, Ra, Rb, n and m are as defined in the instant specification, or by Formula la, lb, III, IV or V, as defined in the instant specification, and uses thereof in modulating an ac...  
WO/2023/132352A1
The present invention provides a method that is for producing an amide compound, that comprises obtaining an amide compound by causing a reaction between a carboxylic acid compound and an amine compound in the presence of a condensing ag...  
WO/2023/122842A1
The present invention relates to a method for preparing apalutamide, having formula (I). The invention also relates to synthesis intermediaries used in the method for preparing apalutamide, having formula XI [compound XI: N-(6-cyano-5-(t...  
WO/2023/123695A1
The present invention belongs to the technical field of drug synthesis, and particularly relates to a dichloroacetic-acid-coupled diphenylethane compound, and a preparation method therefor and the use thereof. The structure of the dichlo...  
WO/2023/124736A1
The present invention relates to the technical field of medical materials, and provides an X-ray developable molecule, an X-ray developable embolic microsphere and a preparation method therefor, comprising the following steps: step 1, pr...  
WO/2023/124236A1
The present invention relates to the preparation of an antiviral drug, and in particular to an intermediate product for synthesizing Paxlovid and a preparation method. The structures of two intermediate products for synthesizing Paxlovid...  
WO/2023/121970A1
The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.  
WO/2023/121753A1
The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, ...  
WO/2023/118576A1
The invention relates to novel, optionally deuterated compounds of Formula (I) and their use as medicament.  
WO/2023/120769A1
The present invention provides a method for preparing an amidopolyamine or imidazoline-type asphalt additive, and an asphalt additive composition prepared thereby. An asphalt additive composition according to one embodiment of the presen...  
WO/2023/117928A1
The object of the present invention is new precursor compounds and derivatives of N- oxalylglycine as well as the cosmetic use of N-oxalylglycine, its precursors and derivatives in the hair field, and in particular for thickening hair.  
WO/2023/114943A2
Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nan...  
WO/2023/114824A1
The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such ...  
WO/2023/115002A1
The present disclosure relates to compound Formula (I) methods for making the compounds and methods for their use.  
WO/2023/114819A1
The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such ...  
WO/2023/114944A1
Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R2a, R2b, R3a, R3b, R7, R8, R9, L1, L2, G1, G2, G3, b, and c are as defined herein. Use of the co...  
WO/2023/107920A1
The present disclosure relates to ionizable lipidoid compounds comprising an anisamide moiety, and lipid nanoparticles (LNPs) comprising the same. In certain embodiments, the LNP selectively binds to at least one sigma receptor. In certa...  
WO/2023/105516A2
The present disclosure relates to a process for preparing a N-substituted acetamide, the process including the steps of: (a) reacting an aniline or derivative thereof with a first amount of a chlorinated acyl chloride in presence of a mi...  
WO/2023/107923A1
This invention relates to, among other items, treating non-tuberculosis Mycobacteria-associated disease in a human with epetraborole.  
WO/2023/104017A1
The present disclosure provides compounds that can inhibit the type III secretion system (TTSS) to decrease the pathogenesis of gram-negative bacteria. These compounds may have wide applications for treating bacteria diseases caused by g...  
WO/2023/107880A1
Disclosed herein are mitofusin inhibitors which are capable of inducing mitochondrial fission, decreasing mitochondrial respiration, TCA metabolism, and inducing mitochondrial outer membrane permeabilization that leads to caspase activat...  
WO/2023/099283A1
The present invention is related to a method for purifying crude α-sulfo fatty acid salt obtained by the reaction of fatty acid and sulfur oxides, comprising the following steps: a) diluting the crude α-sulfo fatty acid in a solvent an...  
WO/2023/093560A1
The present invention discloses a method for preparing an N-fatty acyl amino acid surfactant by means of high-temperature melting and direct condensation. The method of the present invention comprises: mixing a fatty acid, a catalyst and...  
WO/2023/087632A1
The present invention belongs to the field of medicinal chemistry, and specifically disclosed are an anti-inflammatory analgesic compound and the use thereof. The compound of the present invention is a compound having a structure shown i...  
WO/2023/090086A1
Provided are a secondary monohydrofluoroalkane selective adduct and a method for producing the same. A compound represented by formula (3) is produced by means of a method including a step for reacting a compound represented by formula (...  
WO/2023/089594A1
The present invention relates to tirzepatide or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof. The present inven...  
WO/2023/090315A1
A method for producing acetaminophen, the method comprising passing a p-nitrophenol-containing solution, together with an acetylating agent and hydrogen, through a column packed with a catalyst to thereby cause the p-nitrophenol to under...  
WO/2023/090859A1
The present invention relates to: a novel method for preparing an isoxazole derivative, which is useful as a farnesoid X receptor (FXR, NR1H4) agonist; a novel intermediate used in the preparation method; and a method for preparing the p...  
WO/2023/089601A2
The invention relates to compounds that inhibit DUBs, particularly USP9X. The invention also includes methods of inhibiting DUBs, including USP9X, and methods of treating cancers.  
WO/2023/083161A1
Provided in the present invention are a biphenyl heterocyclic compound, and a synthesis method therefor and the use thereof. The biphenyl heterocyclic compound has the following general formula (I). The synthesis process of the biphenyl ...  
WO/2023/078277A1
An intermediate of a polyamine derivative, a preparation method therefor, and a use thereof. The intermediate is easy to prepare and high in purity; and when the intermediate is used for preparing the polyamine derivative, the obtained p...  
WO/2023/077977A1
Disclosed are a compound as represented by the figure for the abstract, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently selected from a group composed of H, methyl, ethyl, n-propyl and isopropyl; a...  
WO/2023/070198A1
The present technology generally relates to a shampoo in solid form including: a system of surfactants, a system of thickening agents, at least one conditioning agent, a system of preservation agents. The shampoo being reconstitutable to...  
WO/2023/073080A1
The present invention relates to a process for preparing aromatic acyl derivatives of formula (I) using methanesulfonic acid. The invention further relates to methods for preparing biological active ingredients, such as paracetamol.  
WO/2023/072143A1
Disclosed in the present invention are a camptothecin derivative intermediate, and a preparation method therefor and the use thereof. The structural formula of the camptothecin derivative intermediate of the present invention is as shown...  
WO/2023/066368A1
Provide crystalline forms of N- (3, 5-difluorobenzyl) -N-hydroxy-2, 2-dimethylbutanamide, methods of preparing and characterizing the crystalline forms, and methods of using the crystalline forms to treat various diseases or conditions, ...  
WO/2023/061437A1
The present invention relates to a salt of an antitumor drug and a crystal form thereof, and specifically relates to a pharmaceutical salt of the compound N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)- 7-oxo-6-phenyl-8(7H)-...  
WO/2023/064493A1
This invention provides compounds for the inhibition of papain-like proteases (PLpros) for the inhibition of viruses, including compounds of formula (I"), and pharmaceutically acceptable salts thereof.  
WO/2023/019242A9
Provided herein are compounds and their pharmaceutically acceptable salts, lipid particles comprising such compounds or pharmaceutically acceptable salts thereof and compositions of the foregoing that can be used to reduce immune intoler...  
WO/2023/062627A1
Provided herein are compounds that inhibit the protein-protein interaction of serine acetyltransferase (SAT) with O-acetyl serine sulfhydrylase (OASS), and can therefore be used as herbicides.  
WO/2023/060955A1
Provided in the present invention is a synthetic method for cetyl-PG hydroxyethyl palmitamide. The method comprises the following steps: firstly, mixing 1,3-dichloropropanol and hexadecyl alcohol under the action of a catalyst and an alk...  
WO/2023/054350A1
The present invention provides a production method for purified dichloroacetic acid and an efficient production method for nucleic acid molecules using same. Specifically, the present invention provides: a production method for purified ...  
WO/2023/050121A1
Disclosed in the present invention are biodegradable glass based on an amino acid, a peptide and a derivative, and a preparation method therefor and an application thereof. A main raw material of the glass is one of or a combination of a...  
WO/2023/053877A1
Provided are: a compound suitable for use as a photodisintegrable base for resist compositions which have satisfactory sensitivity to actinic energy, e.g., EB or EUV, have excellent resolution in lithography, and can give fine patterns r...  
WO/2023/054626A1
Provided is a cyclopropanamide derivative. A compound represented by formula (1) [wherein: n represents an integer of 0, 1, 2 or 3; ring A represents (1) 4-pyridyl which may be substituted with 1 to 4 substituents, or (2) phenyl which is...  
WO/2023/046882A1
There is provided herein compounds of formula I and pharmaceutically acceptable salts thereof, wherein X1, X2, Z, the ring containing Q1 to Q5, m and r have meanings as provided in the description. There is also provided medical uses of ...  
WO/2023/049785A1
Described herein are compounds and compositions for use in treatment or prevention of an inflammatory bowel disease, gastrointestinal cancer, or a systemic bacterial infection in a subject in need thereof. They subject may be colonized b...  
WO/2023/045377A1
The present invention relates to a novel deuterated PEG lipid compound, a preparation method therefor, and a composition and an application thereof. Specifically disclosed are a novel deuterated lipid compound as shown in formula A and f...  
WO/2023/039941A1
Provided are an N,N,N-triacyl-2,4,6-triaminotoluene compound nucleating agent, and a preparation method therefor and a use method thereof. The nucleating agent is used for polymer nucleation at high temperatures, and can effectively redu...  
WO/2023/042715A1
A monomer composition for dental materials which includes a (meth)acrylamide compound (A) including a cyclic structure and a (meth)acrylamide group.  

Matches 101 - 150 out of 15,344