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WO/2018/148113A1 |
The present invention is directed to 13C and/or 2H isotope enhanced ambroxol ("isotope enhanced ambroxol") and its use in the treatment of autophagy infections, especially mycobacterial and other infections, disease states and/or conditi...
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WO/2018/146529A1 |
The present invention relates to a high yield process of preparation of, [1-[2-(Dimethylamino)-1- (4-hydroxyphenyl)ethyl]-cyclohexanol]through potassium hydroxide mediated demethylation of [1-[2-(Dimethyl amino-1-(4-methoxyphenyl) ethyl ...
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WO/2018/144101A1 |
Described herein are labeling agents, specifically [11C]fluoroform, [11C]difluoromethane, [11C]fluoromethyl iodide, [11C]fluoromethyl bromide, [11C]fluoromethyl chloride, [11C]fluoromethyl trifluoromethansulfonate, [11C]difluoromethyl io...
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WO/2018/135506A1 |
The purpose of the present invention is to provide a ruthenium complex which is capable of serving as a reduction catalyst that is applicable to an industrial production. According to the present invention, ketones, aldehydes, esters or ...
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WO/2018/127806A1 |
The present invention provides a process for preparation of isoproterenol hydrochloride (1a) comprising catalytic hydrogenation of 3',4'-dihydroxy-2-(isopropylamino)-acetophenone hydrochloride (5a) in presence of an ion exchange resin, t...
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WO/2018/126040A1 |
The present invention is generally directed to crystalline forms of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-me
thyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcy
clohexanol and processes for their preparation.
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WO/2018/124148A1 |
The purpose of the present invention relates to providing a novel glyceric acid ester which can be produced at a high yield and for which use as a synthesis intermediate can be expected, and a method for producing same. The purpose of th...
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WO/2018/124149A1 |
The purpose of the present invention is to provide a method for producing glyceric acid ester that enables easy, high-yield production and makes it easy to reuse pyridines that are used for a reaction. Provided is a method for producing ...
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WO/2018/124147A1 |
The present invention relates to a method for manufacturing 1,3-dioxane-5-ones by a short and simple method from raw materials that can be obtained easily and inexpensively, using 1,3-dioxane, which is a mixture with 1,3-dioxalans, as a ...
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WO/2018/108888A1 |
The invention pertains to a process for preparing hydroxyethyl ethylene amines and/or ethylene urea derivatives thereof comprising the step of reacting monoethylene glycol with an amine-functional compound comprising at least two -NH- un...
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WO/2018/108698A1 |
The invention relates to a method for producing ethanolamines and/or ethyleneamines in the gas phase by reacting ethylene glycol with ammonia in the presence of an amination catalyst. The method is characterized in that the amination cat...
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WO/2018/104677A1 |
The subject of the invention is a process for continuously producing a (meth)acrylic ester by transesterification reaction between a light C1-C4 alkyl (meth)acrylate and a heavy alcohol in the presence of a catalyst, characterized in tha...
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WO/2018/104176A1 |
The invention relates to a method for producing farnesyl amines by reacting ß-farnesene with one or more amines in the presence of a transition metal catalyst of the10th subgroup, at a temperature in the region of between 60 - 150 °C. (I)
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WO/2018/098799A1 |
The present invention relates to a process for preparing a polyurethane foam by reacting a polyisocyanate with a polyol in the presence of a blow agent and a particular family of amine. The present invention also relates to a polyurethan...
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WO/2018/084625A1 |
The present invention relates to a novel method for preparing (S)-N1-(2-aminoethyl)-3-(4-alkoxyphenyl)propane-1,2-diamine trihydrochloride.
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WO/2018/044982A1 |
A process for preparing a silver-containing catalyst for the selective oxidation of ethylene to ethylene oxide including the steps of: (a) providing a multimodal support, (b) preparing an impregnation solution comprising a silver compone...
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WO/2018/032522A1 |
A supported catalyst used for synthesizing a polyether amine, and a manufacturing method of the catalyst. The catalyst comprises: a porous oxide as a support; Ni, Cu, Pd, and Rh as an active component; and one or more of any of Zr, Cr, M...
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WO/2018/028679A1 |
A post-processing method for a Mirabegron intermediate, comprising the following steps: with a Mirabegron carbonyl of formula I serving as a reaction raw material, the carbonyl therein is reduced via a reduction reaction under the effect...
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WO/2018/021517A1 |
The present invention relates to a 4-alkoxy-3-(trifluoromethyl)benzyl alcohol production method with which it is possible to achieve a higher conversion rate and to closely control the generation of by-products by using DIBAL as a reduci...
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WO/2018/020380A1 |
The present invention provides process for preparation of enantiomerically pure (R)-3- aminobutan-1-ol (I) by treating 4-hydroxybutan-2-one (II) with transaminase enzyme and use of enantiomerically pure (R)-3-aminobutan-1-ol (I) in the p...
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WO/2017/067497A9 |
Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups s...
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WO/2017/212059A1 |
The present invention relates to a new process of manufacturing of caged cyclofen-OH and derivatives thereof, of formula (I) or salts thereof, wherein n, R1, R1 ', R2, and R3 are as defined in the claims.
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WO/2017/207839A1 |
The invention relates to a method for obtaining β-amino alcohols, in which the following steps are performed using amines and a diol/water mixture: adding a catalytic mixture to the starting amine; next, adding the diol/water mixture; s...
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WO/2017/206692A1 |
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions and/or organic amine B cations; m ...
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WO/2017/206693A1 |
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions, hydrazine ions and/or organic ami...
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WO/2017/209235A1 |
The present invention addresses the problem of providing a low-cost and highly-safe method for producing a polycyclic aromatic aminophenol compound in a small number of steps. The method for producing a polycyclic aromatic aminophenol co...
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WO/2017/193913A1 |
Provided are a fosaprepitant phosphate intermediate (IV) preparation method, a fosaprepitant phosphate intermediate (IV-A) and a method (AA) for preparing fosaprepitant dimeglumine by using the intermediate (IV-A). IV: R1 and R2 are inde...
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WO/2017/187067A1 |
The invention relates to the use of 2,6-di-tert-butyl-4-methylphenol at a moiety of 25 to 200 ppm for stabilizing N,N-dimethylaminoethyl acrylate in respect of discoloring effects. The invention also relates to an N,N-dimethylaminoethyl ...
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WO/2017/181380A1 |
A silver nanoparticle-composite fabric-supported catalyst, and use thereof. Silver nanoparticles are carried on the surface of fabric fibers by means of an in-situ growth method, and are in a range of 1-50 nm. The silver nanoparticle-com...
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WO/2017/183835A1 |
The present invention relates to a method for preparing a D-4,4'-biphenylalanine alkyl ester or an L-4,4'-biphenylalanine alkyl ester by optically splitting a DL-4,4'-biphenylalanine alkyl ester using a chiral diaroyl tartaric acid as an...
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WO/2017/179976A1 |
The invention relates to improved means and methods for N- dealkylation of alkylated amines. Provided is a method for the catalytic N- dealkylation of an N-alkylated amine substrate, comprising incubating said amine substrate in a suitab...
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WO/2017/168444A1 |
The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I),
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WO/2017/162476A1 |
An etheramine mixture comprising of at least one amine selected from the group consisting of amine of Formula (I) and amine of Formula (II) wherein R1-R12 are independently selected from H, alkyl, cycloalkyi, aryl, alkylaryl, or arylalky...
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WO/2017/162477A1 |
An etheramine mixture comprising at least 90% by weight, based on the total weight of the etheramine mixture, of an amine of Formula (I) and/or (II), wherein R1-R12 are independently selected from H, alkyl, cycloalkyl, aryl, alkylaryl, o...
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WO/2017/160933A1 |
The present invention relates to a novel process for converting the unwanted S enantiomer form to its useful raceme with respect to a 4- aminoindane derivative.
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WO/2017/159814A1 |
The present invention provides a method for producing ethanolamines whereby it is possible to keep the yield of dialkanolamines low (for example, less than 30% by weight). This method for producing alkanolamines involves reacting an alky...
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WO/2017/142028A1 |
A metal-supported macromolecule and a use thereof as a catalyst, said metal-supported macromolecule being obtained by causing a ligand to react with a zinc compound or a cobalt compound, said ligand having an imidazole group that is bond...
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WO/2017/136976A1 |
The present invention discloses an ionic liquid having a methanofullerene carboxylate as an anion, and a preparation method thereof. The ionic liquid is comprised of the methanofullerene carboxylate anion and a quaternary ammonium cation...
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WO/2017/137955A1 |
The present invention relates to novel chiral 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylprop
an-1-amine (5) and racemic 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylprop
an-1-amine () and its use in improved and ...
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WO/2017/123333A1 |
The present disclosure provides a process for the co-preparation of a polyetheramine and an alkylene amine mixture by aminating a liquid polyol initiator mixture comprising an alkoxylated alcohol and a solid high melting polyol. The poly...
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WO/2017/122730A1 |
[Problem] To provide a novel diamine that produces a film having excellent flexibility and transparency and also having low retardation characteristics. [Solution] Disclosed are: a diamine characterized by being represented by formula (1...
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WO/2017/115256A1 |
A method of reducing color in an alkanolamine, the method comprising: contacting the alkanolamine with an amount of an aqueous solution effective to provide 5 to 1000 parts per million by weight of an alkali metal borohydride, based on p...
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WO/2017/102659A1 |
The invention relates to a method for synthesising at least one nitrogen compound belonging to the family of the partially N-hydroxyethylated tertiary 1,6-hexanediamines of the following general formula (I) in which the groups R1, R2 and...
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WO/2017/098408A1 |
A method of reducing color in an alkanolamine is described. The method includes contacting the alkanolamine with a color-reducing amount of a borane complex effective to provide a color-reduced alkanolamine composition having a Platinum-...
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WO/2017/095677A1 |
A process for synthesizing 2-methoxymethyl-l,4-benzenediamines which comprises a radical halogenation step of compounds of formula (II) to compounds of formula (III). The final product can be 2-methoxymethyl-l,4-benzenediamine useful as ...
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WO/2017/079965A1 |
The present invention relates to a catalyst for aminating a polyether polyol and preparation method thereof and a method of preparing a polyetheramine using the catalyst. The catalyst has active components and a carrier. The active compo...
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WO/2017/076293A1 |
The invention relates to a method for preparing an oxazolidinone intermediate. Specifically, a synthesis procedure for the intermediate comprises: directly performing a "one-pot" reaction on a compound I, a compound J or a compound L wit...
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WO/2017/070651A1 |
Disclosed is a process for preparing (Z)-endoxifen, comprising (i) recrystallizing an input crystalline solid comprising a mixture of (Z)-endoxifen (1) and (E)-endoxifen (2) from a first solvent to provide a first crystalline solid and a...
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WO/2017/042514A1 |
The present invention relates to a compound of formula (I): in which: - the R1 and R2 groups, which may be identical or different, are, independently of one another, a saturated or unsaturated, linear, branched or cyclic hydrocarbon grou...
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WO/2017/035879A1 |
The present invention provides a method for preparing single-layer metal phosphate and applications thereof. The method comprises: (1) carrying out intercalation treatment on layered metal phosphate by means of alkylol amine, so as to ob...
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