| Document |
Document Title |
|
WO/2012/133182A1 |
The objective of the present invention is to provide a polyether compound which is useful as a curing agent and the like, a curing agent which uses the compound, and a method for producing the compound. A polyether compound of the presen...
|
|
WO/2012/126363A1 |
Disclosed are an amorphous asiatic tromethamine salt and the preparation method thereof. The method comprises the steps of: (1) dissolving asiatic acid in an organic solvent; (2) mixing with tromethamine; (3) stirring and salifying the s...
|
|
WO/2012/119928A1 |
The invention relates to a method for producing alkanol amines which comprise a primary amino group (-NH2) and a hydroxyl group (-OH), by alcohol amination of diols comprising two hydroxyl groups (-OH), using ammonia, and elimination of ...
|
|
WO/2012/120003A1 |
The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
|
|
WO/2012/119927A1 |
The invention relates to a method for producing primary amines comprising at least one functional group of formula (-CH2-NH2), by alcohol amination of educts which comprise at least one functional group of formula (–CH2-OH), using ammo...
|
|
WO/2012/118441A1 |
The present invention provides an efficient and scalable process to prepare the compound of formula 4 by reduction of the corresponding α-acyloxy sulfides.
|
|
WO/2012/113475A1 |
The present invention relates to a chemocatalytic liquid-phase process for the direct single-stage amination of alcohols to primary amines using ammonia in high yields by means of a catalyst system containing at least one transition meta...
|
|
WO/2012/113860A2 |
The invention relates to a compound of formula (1): where R1 through R8, which can be identical or different from each other, each are selected from of the group comprising hydrogen and the radical -(CH2)k-X, where k is a whole number fr...
|
|
WO/2012/111856A1 |
The present invention provides a novel process for producing 2-amino-3-butene-1-ol compound. A process for producing 2-amino-3-butene-1-ol compound of the following formula (2) comprising a step of reacting an alkenylimide compound of th...
|
|
WO/2012/108777A1 |
The present invention relates to a process for the manufacture of APD and N-alkyl-APD wherein 1-CPD is reacted with aqueous ammonium or aqueous alkyl-amine under alkaline conditions and where the process is conducted in a continuous mann...
|
|
WO/2012/100399A1 |
Provided is a process for synthesizing Fingolimod hydrochloride comprising the following steps: (1) reacting a compound (5) with a sulfhydryl compound (I) under alkaline conditions to produce a key intermediate product (6); (2) oxidizing...
|
|
WO/2012/098044A1 |
The invention concerns an improved process for the preparation of tolterodine (N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl propyl amine) and its salts, in particular for the preparation of the tartrate salt, and more particular...
|
|
WO/2012/098521A1 |
Use of homogeneous catalytic systems which include as a pre-catalyst a complex of a group 4 metal and a Salan ligand in the polymerization of alpha-olefins, is disclosed. The Salan ligand is characterized by a sequential diamino-containi...
|
|
WO/2012/089177A1 |
The present solution relates to a method comprising, as a key step, production of optically pure or optically enriched tapentadol of formula I, in which optically pure or optically enriched (2R,3R)-amines of general formula V, wherein R ...
|
|
WO/2012/089181A1 |
The compounds of general formula II are new and represent important intermediates in the synthesis of tapentadol. In the synthesis of tapentadol of formula I and its pharmaceutically acceptable salts, O-protected (2R,3R)-acids of general...
|
|
WO/2012/089238A1 |
The invention relates to a process of making crystalline fingolimod hydrochloride of Formula (1a), comprising a step of contacting a solution of fingolimod hydrochloride in a solvent with an antisolvent at an enhanced temperature, and co...
|
|
WO/2012/080240A1 |
The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, parti...
|
|
WO/2012/080233A1 |
The invention relates to a method for purifying a reaction product containing 3-aminopropanol, said reaction product being produced in the reaction of ethylene cyanohydrin with hydrogen in the presence of ammonia, characterized in that t...
|
|
WO/2012/076783A1 |
The invention concerns special (meth)acrylic monomers and relates more particularly to an improved process for preparing alkylaminoalkyl (meth)acrylates, in particular monoalkylaminoalkyl (meth)acrylates, in the presence of a catalyst se...
|
|
WO/2012/076560A1 |
The present invention provides a process for preparing primary amines, comprising the steps of A) providing a solution of a primary alcohol in a fluid, non-gaseous phase, B) contacting the phase with free ammonia and/or at least one ammo...
|
|
WO/2012/072441A1 |
The invention relates to the use of a component according to one of the formulae (I) or (II), formula (I) being (R1R2NR3)2NR4, formula (II) being (R1R2NR3)NH2, wherein - each of R1 and R2 are chosen from the group consisting of a methyl ...
|
|
WO/2012/071896A1 |
Compounds of formula I, uses as crosslinking agents or curing agents thereof, and resins obtained by using the compounds as crosslinking agents.
|
|
WO/2012/074536A1 |
A process for synthesizing 2-methoxymethyl-1,4-benzenediamine, its derivatives of formula (IV) and the salts thereof, which comprises a reductive amination step. The preferred final product is 2-methoxymethyl-1,4-benzenediamine of formul...
|
|
WO/2012/070025A1 |
The present invention relates to a process for the manufacture of N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide (Agomelatine) with improved yield and reduced level of N- acetyl-N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide impurity.
|
|
WO/2012/070059A1 |
Crystalline polymorphic forms of fingolimod hydrochloride, their XRPD patterns and preparation are provided. Processes for preparing crystalline polymorphic forms-α, β and μ substantially free from processes related impurities are als...
|
|
WO/2012/068284A2 |
The disclosed process can efficiently synthesize functionalized benzosuberenes. The process provides an improved method of production of benzosuberene and compounds containing a benzosuberene moiety, which is characterized by a ring clos...
|
|
WO/2012/050593A1 |
Disclosed is a method of making a 2-substituted-1,4-benzenediamine by nucleophilic aromatic substitution.
|
|
WO/2012/048887A1 |
A process for the synthesis of chiral propargylic alcohols.
|
|
WO/2012/050263A1 |
Provided is a method of preparing endoxifen by coupling 4,4-hydroxybenzophenone as a starting material with propiophenone. The method can be used to obtain an E/Z-form endoxifen mixture with a high yield compared to the conventional meth...
|
|
WO/2012/044508A1 |
Provided is a process for making a tertiary aminoalcohol compound. The process comprises using an excess amount of a carbonyl compound in a condensation step between the carbonyl compound and a nitroalkane, and conducting a hydrogenation...
|
|
WO/2012/041013A1 |
The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
|
|
WO/2012/044758A1 |
Disclosed is a method of making 2-methoxymethyl-1,4-benzenediamine that includes hydrogenating 1-benzylamino-2-(methoxymethyl)-4-nitrobenzene in the presence of a hydrogenation catalyst.
|
|
WO/2012/040133A2 |
Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal...
|
|
WO/2012/040151A2 |
Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal...
|
|
WO/2012/040138A2 |
Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal...
|
|
WO/2012/038974A1 |
Provided is a process for the preparing l-phenyl-3-dimethylaminopropane derivatives of formula I, (The formula should be inserted here) and its pharmaceutically acceptable salts thereof via novel intermediates.
|
|
WO/2012/038459A1 |
The present invention relates to a process for preparing (meth)acrylic esters (F) of N,N‑substituted amino alcohols, by transesterifying N,N‑substituted amino alcohols (I) in which Y and Z are each independently C1-C20-alkyl, C3-C15-...
|
|
WO/2012/032546A2 |
The present invention discloses a process for the preparation of methyl 2-(benzyloxy)- 5-(2-bromoacetyl)benzoate (V), comprising: (d) benzylating methyl-5-acetyl-2-hydroxybenzoate (VIII) with benzyl chloride in the presence of a base and...
|
|
WO/2012/028323A1 |
Described is a process for the preparation of halogenated 4,4'-methylene-bis- anilines by a direct halogenation of 4,4'-methylene-bis-anilines. High yields and a flexible control of the grade of halogenation at the aromatic rings can be ...
|
|
WO/2012/023147A1 |
Disclosed herein is an improved process for the preparation of 3-[(2R,3R)-1- (dimethylamino)-2-methylpentan-3-yl] phenol of Formula - I and its pharmaceutically acceptable salt which comprises the reaction of (S)-1-(dimethylamino)-2-meth...
|
|
WO/2012/020418A1 |
The present invention relates to novel polymorphs of 4-hydroxy Atomoxetine hydrochloride and process for the preparation thereof. The present invention also relates to crystalline monohydrate and anhydrate forms of 4-hydroxy Atomoxetine ...
|
|
WO/2012/013848A1 |
Difluorobenzyl ethanolamine derivatives with antimicrobial activity, belonging to the field of chemistry/medicine. Reference is made to a method for synthesizing fluorinated ethanolamine molecules, specifically difluorobenzyl ethanolamin...
|
|
WO/2012/005693A1 |
The present invention relates to a method for the synthesis of an α amino acetal, comprising (i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or (ii) reacting a secondary amine and...
|
|
WO/2012/003476A2 |
Embodiments of hapten conjugates including a hapten, an optional linker, and a peroxidase- activatable aryl moiety are disclosed. In some embodiments, the peroxidase- activatable aryl moiety is tyramine or a tyramine derivative. Embodime...
|
|
WO/2012/000498A1 |
The present invention relates to the crystalline, polymorphic Form C of the calcimimetic compound {4-[(1R,3S)-3-((R)-1-Naphthalen-1-yl-ethylamino)-cyclopentyl
]-phenoxy}-acetic acid, to methods of preparation thereof, to methods of chara...
|
|
WO/2012/000499A1 |
The present invention relates to the crystalline, polymorphic Form X of the calcimimetic compound {4-[(1R, 3S)-3-((R)-1 -Naphthalen-1 -yl-ethylamino)-cyclopentyl]-phenoxy}-acetic acid, to methods of preparation thereof, to methods of cha...
|
|
WO/2011/157390A2 |
The present invention relates to a process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds.
|
|
WO/2011/158959A1 |
Disclosed is a process for producing an intermediate for a cyclic carbodiimide compound. Specifically disclosed are: a process for producing an amine compound represented by formula (B), which involves a step of reducing a nitro compound...
|
|
WO/2011/154152A1 |
The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3 -mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming 0 - desmethylvenlafaxine.
|
|
WO/2011/151120A1 |
The invention relates to novel quaternary ammonium compounds of the esterquat type, to a method for the production thereof, and to the use thereof in formulations.
|
