USE OF PREVOTELLA IN PREVENTION AND TREATMENT OF ATTENTION DEFICIT-HYPERACTIVITY DISORDER

Title:

USE OF PREVOTELLA IN PREVENTION AND TREATMENT OF ATTENTION DEFICIT-HYPERACTIVITY DISORDER

Document Type and Number:

WIPO Patent Application WO/2024/061169

Kind Code:

A1

Abstract:

The present invention provides use of Prevotella in the prevention and treatment of attention deficit-hyperactivity disorder. The Prevotella is used at a therapeutically effective amount to achieve the treatment of attention deficit-hyperactivity disorder. The strain number of the Prevotella is JCM 13464 = DSM 18205. The Prevotella has a quite significant effect on the improvement of a hyperactive behavior, a spontaneous activity level, and an impulsive behavior. The Prevotella can significantly increase levels of adrenocorticotropic hormone and cortisol in serum, improve the dysfunction of a neuroendocrine system, and significantly increase the gene expression of a glucocorticoid receptor (Nr3c1) and a mineralocorticoid receptor (Nr3c2), thereby alleviating the social dysfunction of ADHD.

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Inventors:

QIU JINGFU (CN)
CHEN CHENGZHI (CN)
ZOU ZHEN (CN)
LIU YIYUN (CN)
GUO ZHANGXIN (CN)

Application Number:

PCT/CN2023/119447

Publication Date:

March 28, 2024

Filing Date:

September 18, 2023

Export Citation:

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Assignee:

UNIV CHONGQING MEDICAL (CN)

International Classes:

A61K35/741; A61P25/14; C12R1/01

Foreign References:

CN115607575A	2023-01-17
CN115003318A	2022-09-02
CN101420953A	2009-04-29
CN112218685A	2021-01-12
CN113855709A	2021-12-31
CN113509494A	2021-10-19

Other References:

SASAKI-IMAMURA TAKAKO, YOSHIDA YASUO, SUWABE KYOSUKE, YOSHIMURA FUMINOBU, KATO HIROHISA: "Molecular basis of indole production catalyzed by tryptophanase in the genus Prevotella : Indole production by tryptophanase in the genus Prevotella", FEMS MICROBIOLOGY LETTERS, NO LONGER PUBLISHED BY ELSEVIER, vol. 322, no. 1, 27 June 2011 (2011-06-27), pages 51 - 59, XP093150847, ISSN: 0378-1097, DOI: 10.1111/j.1574-6968.2011.02329.x

Attorney, Agent or Firm:

BEIJING XINKEHUALING IP SERVICE AGENT (CN)

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