Title:
USE OF JWA POLYPEPTIDE IN PREPARATION OF ANTI-TUMOR DRUG CO-POTENTIATOR
Document Type and Number:
WIPO Patent Application WO/2024/082408
Kind Code:
A1
Abstract:
The present invention relates to a use of a JWA polypeptide in the preparation of an anti-tumor drug co-potentiator. The amino acid sequence of the polypeptide is as shown in I or II: I: FPGSDRF-Z, and II: X-FPGSDRF-Z, the amino acid S being subject to phosphorylation modification, and X and Z each being amino acids or amino acid sequences; X is selected from one of F, (R)9, (R)9-F, 6-aminocaproic acid, 6-aminocaproic acid-F, 6-aminocaproic acid-(R)9, 6-aminocaproic acid-(R)9-F; Z is selected from one of (G)n-RGD and A-(G)n-RGD, n being an integer greater than or equal to 0, and n having a value ranging from 0 to 10. The polypeptide can improve a hypoxic state of a tumor microenvironment, can promote tumor blood vessel normalization so as to inhibit initiation and occurrence of tumor metastasis, can increase the effective perfusion amount of drugs in tumors, and may be used as an anti-tumor drug co-potentiator, possibly providing a new clinical medication for treating tumors.
Inventors:
ZHOU JIANWEI (CN)
Application Number:
PCT/CN2022/138739
Publication Date:
April 25, 2024
Filing Date:
December 13, 2022
Export Citation:
Assignee:
SUZHOU MINGREN PHARMACEUTICAL BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K38/08; A61K31/337; A61P35/00
Foreign References:
| CN103239710A | 2013-08-14 | |||
| CN115414465A | 2022-12-02 | |||
| CN114940702A | 2022-08-26 | |||
| US20210047313A1 | 2021-02-18 |
Other References:
JIAWEI SUN: "Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides", INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS, NEW ZEALAND, vol. 12, 1 January 2017 (2017-01-01), New Zealand , pages 1517 - 1537, XP093160667, ISSN: 1178-2013, DOI: 10.2147/IJN.S122859
Attorney, Agent or Firm:
NANJING IPLEADER INTELLECTUAL PROPERTY AGENCY FIRM (CN)
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