Title:
UNIVERSAL CAR-T CELL TARGETING CD7
Document Type and Number:
WIPO Patent Application WO/2024/083213
Kind Code:
A1
Abstract:
The present invention relates to a modified T cell, a preparation method therefor and a use thereof. The expression of endogenous TRAC, B2M and CD7 genes in the T cell is inhibited, and the T cell expresses a chimeric antigen receptor targeting CD7. The modified T cell can be used to treat diseases associated with CD7 expression.
Inventors:
ZHAO YANGBING (CN)
LIU XIAOJUN (CN)
ZHU GENGZHEN (CN)
LIU XIAOJUN (CN)
ZHU GENGZHEN (CN)
Application Number:
PCT/CN2023/125577
Publication Date:
April 25, 2024
Filing Date:
October 20, 2023
Export Citation:
Assignee:
UTC THERAPEUTICS SHANGHAI CO LTD (CN)
International Classes:
C12N5/10; A61K39/395; A61P35/00; C07K16/18
Domestic Patent References:
| WO2023155852A1 | 2023-08-24 |
Foreign References:
| CN114369622A | 2022-04-19 | |||
| CN114317607A | 2022-04-12 | |||
| CN115052902A | 2022-09-13 | |||
| CN114525259A | 2022-05-24 | |||
| CN114921417A | 2022-08-19 |
Other References:
FREIWAN, A. ET AL.: "Engineering Naturally Occurring CD7- T Cells for the Immunotherapy of Hematological Malignancies", BLOOD, vol. 140, no. 25, 1 August 2022 (2022-08-01), XP087236071, DOI: 10.1182/blood.2021015020
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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