Title:
TREATMENT AGENT FOR LUNG ADENOCARCINOMAS
Document Type and Number:
WIPO Patent Application WO/2024/024895
Kind Code:
A1
Abstract:
The present invention provides a treatment agent for NK2 Homeobox 1 (NKX2-1)-negative lung adenocarcinomas that includes a Porcupine inhibitor as an active ingredient, an NKX2-1-negative lung adenocarcinoma organoid, and a screening method for treatment agents for NKX2-1-negative lung adenocarcinomas that includes a step for culturing an NKX2-1-negative lung adenocarcinoma organoid in the presence of a test substance and a step for measuring the growth of the NKX2-1-negative lung adenocarcinoma organoid, wherein a reduction in the growth of the NKX2-1-negative lung adenocarcinoma organoid as compared to absence of the test substance indicates that the test substance is a treatment agent for NKX2-1-negative lung adenocarcinomas.
Inventors:
YASUDA HIROYUKI (JP)
SATO TOSHIRO (JP)
EBISUDANI TOSHIKI (JP)
FUKUNAGA KOICHI (JP)
SATO TOSHIRO (JP)
EBISUDANI TOSHIKI (JP)
FUKUNAGA KOICHI (JP)
Application Number:
PCT/JP2023/027599
Publication Date:
February 01, 2024
Filing Date:
July 27, 2023
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
A61K45/00; A61K31/444; A61P35/00; C12N5/02; C12N5/071; C12Q1/04
Domestic Patent References:
| WO2021241621A1 | 2021-12-02 | |||
| WO2018164174A1 | 2018-09-13 | |||
| WO2022031952A2 | 2022-02-10 |
Foreign References:
| JP2018519308A | 2018-07-19 | |||
| JP2008263837A | 2008-11-06 |
Other References:
ZEWDU REDIET, MEHRABAD ELNAZ MIRZAEI, INGRAM KELLEY, FANG PENGSHU, GILLIS KATHERINE L, CAMOLOTTO SOLEDAD A, ORSTAD GRACE, JONES AL: "An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma", ELIFE, ELIFE SCIENCES PUBLICATIONS LTD., GB, vol. 10, 6 April 2021 (2021-04-06), GB , pages e66788, XP093132611, ISSN: 2050-084X, DOI: 10.7554/eLife.66788
EBISUDANI TOSHIKI, HAMAMOTO JUNKO, TOGASAKI KAZUHIRO, MITSUISHI AKIFUMI, SUGIHARA KAI, SHINOZAKI TARO, FUKUSHIMA TAKAHIRO, KAWASAK: "Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma", CELL REPORTS, ELSEVIER INC, US, vol. 42, no. 3, 1 March 2023 (2023-03-01), US , pages 112212, XP093132612, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2023.112212
EBISUDANI TOSHIKI, HAMAMOTO JUNKO, TOGASAKI KAZUHIRO, MITSUISHI AKIFUMI, SUGIHARA KAI, SHINOZAKI TARO, FUKUSHIMA TAKAHIRO, KAWASAK: "Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma", CELL REPORTS, ELSEVIER INC, US, vol. 42, no. 3, 1 March 2023 (2023-03-01), US , pages 112212, XP093132612, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2023.112212
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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