Title:
THERAPEUTIC AGENT FOR IMMUNE/INFLAMMATORY DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/075474
Kind Code:
A1
Abstract:
The present invention provides a therapeutic agent for immune/inflammatory disease in which an anti-human TIGIT antibody that activates an inhibitory immune checkpoint molecule (TIGIT) serves as an active ingredient. Furthermore, the present invention provides an antibody having the characteristics of a) and b): a) CDR3 of the heavy chain variable region includes the amino acid sequence of SEQ ID NO: 4; and b) CDR3 of the light chain variable region includes the amino acid sequence of SEQ ID NO: 6.
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Inventors:
TAKEUCHI TSUTOMU (JP)
YOSHIMURA AKIHIKO (JP)
SUZUKI KATSUYA (JP)
TAKESHITA MASARU (JP)
KOJIMA MARENORI (JP)
KASSAI YOSHIAKI (JP)
KORO TAKU (JP)
SEKIYA KEIKO (JP)
YOSHIHARA TOMOKI (JP)
ADACHI RYUTARO (JP)
YOSHIMURA AKIHIKO (JP)
SUZUKI KATSUYA (JP)
TAKESHITA MASARU (JP)
KOJIMA MARENORI (JP)
KASSAI YOSHIAKI (JP)
KORO TAKU (JP)
SEKIYA KEIKO (JP)
YOSHIHARA TOMOKI (JP)
ADACHI RYUTARO (JP)
Application Number:
PCT/JP2021/037471
Publication Date:
April 14, 2022
Filing Date:
October 08, 2021
Export Citation:
Assignee:
UNIV KEIO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61K39/395; A61P29/00; A61P37/02; C07K16/28; C12N15/13
Domestic Patent References:
| WO2015143343A2 | 2015-09-24 |
Foreign References:
| JP2006512407A | 2006-04-13 | |||
| JP2008544746A | 2008-12-11 | |||
| JP2011523034A | 2011-08-04 | |||
| US84165407A | 2007-08-20 | |||
| US20040013210A1 | 2004-01-22 | |||
| US20050054832A1 | 2005-03-10 | |||
| US20060024298A1 | 2006-02-02 | |||
| US4937190A | 1990-06-26 | |||
| JP2020171278A | 2020-10-22 |
Other References:
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
PROCEEDING OF THE SOCIETY FOR THE BIOLOGICAL MEDICINE, vol. 73, 1950, pages 1
"Immunochemical Techniques", vol. 121, ACADEMIC PRESS, article "Monoclonal Antibodies and General Immunoassay Methods"
"Remington's Pharmaceutical Science", 1980
VIROLOGY, vol. 8, 1959, pages 396
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
PROCEEDING OF THE SOCIETY FOR THE BIOLOGICAL MEDICINE, vol. 73, 1950, pages 1
"Immunochemical Techniques", vol. 121, ACADEMIC PRESS, article "Monoclonal Antibodies and General Immunoassay Methods"
"Remington's Pharmaceutical Science", 1980
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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