Title:
TEMPERATURE-CONTROLLABLE, SELF-REPLICATING RNA VACCINES FOR VIRAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/266511
Kind Code:
A8
Abstract:
The present disclosure relates to mRNA, self-replicating RNA, and temperature-sensitive, self-replicating RNA encoding a coronavirus nucleocapsid protein or an influenza virus nucleocapsid protein in operable combination with a mammalian signal peptide. The present disclosure relates to mRNA, self-replicating RNA, and temperature-sensitive, self-replicating RNA encoding other viral nucleocapsid protein(s) in operable combination with a mammalian signal peptide. The RNA constructs are suitable for active immunization against a virus in a mammalian subject, such as a human subject.
Inventors:
KO MINORU S (US)
Application Number:
PCT/US2022/034104
Publication Date:
November 09, 2023
Filing Date:
June 17, 2022
Export Citation:
Assignee:
ELIXIRGEN THERAPEUTICS INC (US)
International Classes:
C12N15/62; A61K31/7088; A61K39/00; A61K39/12; A61K39/145; A61K39/215; A61K39/295; A61P31/14; C07K14/005; C12N7/00; C12N15/85
Attorney, Agent or Firm:
LEKUTIS, Christine et al. (US)
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