SUPER-HIGH-MOLECULAR GAMMA-POLYGLUTAMIC ACID, BACILLUS GENUS BACTERIUM VARIANT STRAIN THAT PRODUCES SAID POLYGLUTAMIC ACID, AND METHOD FOR SCREENING FOR SAID BACILLUS GENUS BACTERIUM VARIANT STRAIN

Title:

SUPER-HIGH-MOLECULAR GAMMA-POLYGLUTAMIC ACID, BACILLUS GENUS BACTERIUM VARIANT STRAIN THAT PRODUCES SAID POLYGLUTAMIC ACID, AND METHOD FOR SCREENING FOR SAID BACILLUS GENUS BACTERIUM VARIANT STRAIN

Document Type and Number:

WIPO Patent Application WO/2024/071279

Kind Code:

A1

Abstract:

Provided is a super-high-molecular gamma-polyglutamic acid having an average molecular weight of at least 20 million. Also provided is a Bacillus genus bacterium variant strain that can produce said super-high-molecular γ-PGA. Further provided is a method for screening for said Bacillus genus bacterium variant strain that can produce said super-high-molecular γ-PGA. The present invention produces Bacillus genus bacterium variant strain, and produces a gamma-polyglutamic acid having an average molecular weight of at least 20 million.

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Inventors:

ISHIKAWA SHU (JP)
YAMAMOTO JUNYA (JP)
CHUMSAKUL ONUMA (JP)

Application Number:

PCT/JP2023/035341

Publication Date:

April 04, 2024

Filing Date:

September 28, 2023

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Assignee:

UNIV KOBE NAT UNIV CORP (JP)

International Classes:

C12N1/20; C07K14/32; C12N15/01; C12N15/31

Domestic Patent References:

WO2004007593A1

2004-01-22

Foreign References:

JP2002233391A	2002-08-20
JP2016121287A	2016-07-07
JP2002210307A	2002-07-30
JP2010213665A	2010-09-30

Other References:

YINGYUN PENG: "High-level production of poly(γ-glutamic acid) by a newly isolated glutamate-independent strain, Bacillus methylotrophicus", PROCESS BIOCHEMISTRY, ELSEVIER LTD, GB, vol. 50, no. 3, 1 March 2015 (2015-03-01), GB , pages 329 - 335, XP093155908, ISSN: 1359-5113, DOI: 10.1016/j.procbio.2014.12.024
HSUEH YI-HUANG, HUANG KAI-YAO, KUNENE SIKHUMBUZO, LEE TZONG-YI: "Poly-γ-glutamic Acid Synthesis, Gene Regulation, Phylogenetic Relationships, and Role in Fermentation", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 12, 7 December 2017 (2017-12-07), pages 2644, XP055882513, DOI: 10.3390/ijms18122644
KAZUHISA SAWADA: "Poly-l-gamma-glutamic acid production by recombinant Bacillus subtilis without pgsA gene", AMB EXPRESS, SPRINGER-VERLAG, DE, vol. 8, no. 1, 1 December 2018 (2018-12-01), DE , pages 110, XP093155909, ISSN: 2191-0855, DOI: 10.1186/s13568-018-0636-x

Attorney, Agent or Firm:

SAEGUSA & PARTNERS (JP)

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