Title:
SUBSTITUTED ISOINDOLIN-1,3-DIONE PDE4 INHIBITOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/015944
Kind Code:
A1
Abstract:
The present invention relates to a compound as represented by formula I and a racemate, stereoisomer, tautomer, isotope labeled substance, solvate, polymorph, ester, prodrug or pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, a preparation method therefor and the pharmaceutical use thereof. The structure of the formula I is as follows:
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Inventors:
ZHU JIAWANG (CN)
YAO YAO (CN)
YAO YAO (CN)
Application Number:
PCT/CN2022/088776
Publication Date:
February 16, 2023
Filing Date:
April 24, 2022
Export Citation:
Assignee:
SUZHOU INTRAGRAND PHARMA CO LTD (CN)
International Classes:
C07D209/48; A61K31/4035; A61P1/00; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P17/08; A61P19/02; A61P29/00; C07D209/49
Domestic Patent References:
| WO2018157779A1 | 2018-09-07 | |||
| WO2021119571A1 | 2021-06-17 | |||
| WO2001034606A1 | 2001-05-17 | |||
| WO2000025777A1 | 2000-05-11 | |||
| WO2012083153A1 | 2012-06-21 | |||
| WO2018157779A1 | 2018-09-07 | |||
| WO2001034604A2 | 2001-05-17 | |||
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Foreign References:
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FRIIS, S. D. ET AL.: "Cobalt-Catalysed C–H Methylation for Late-Stage Drug Diversification", NATURE CHEMISTRY, vol. 12, no. 6, 29 May 2020 (2020-05-29), XP037153279, ISSN: 1755-4349, DOI: 10.1038/s41557-020-0475-7
BHOLE RITESH P, NAKSAKHARE SACHIN R, BONDE CHANDRAKANT G: "A Stability Indicating HPTLC Method for Apremilast and Identification of degradation products using MS/MS", JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, CUDDALORE, vol. 11, no. 5, 1 May 2019 (2019-05-01), Cuddalore, pages 1861 - 1869, XP093034686
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BEAVOREITSNYDER, TRENDS IN PHARM., vol. 11, 1990, pages 150 - 155
VERGHES ET AL., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 272, no. 3, 1995, pages 1313 - 1320
TRACEY ET AL., NATURE, vol. 330, 1987, pages 662 - 664
HINSHAW ET AL., CIRCLE. SHOCK, vol. 30, 1990, pages 279 - 292
MILLAR ET AL., LANCET, vol. 2, 1989, pages 712 - 714
FERRAI-BALIVIERA ET AL., ARCH SURG., vol. 124, 1989, pages 1400 - 1405
BERTOLINI ET AL., NATURE, vol. 319, 1986, pages 516 - 518
PIGNET ET AL., NATURE, vol. 344, 1990, pages 245 - 247
BISSONNETTE ET AL., INFLAMMATION, vol. 13, 1989, pages 329 - 339
BAUGHMAN ET AL., J LAB. LIN. MED., vol. 115, 1990, pages 36 - 42
ELLIOT ET AL., INT. J. PHARMAC., vol. 17, 1995, pages 141 - 145
VON DULLEMEN ET AL., GASTROENTEROLOGY, vol. 109, 1995, pages 129 - 135
LOWE, EXP. OPIN. THER. PATENTS, vol. 8, 1998, pages 1309 - 1332
JACQUES, J. ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY-INTERSCIENCE
WILEN, S.H. ET AL., TETRAHEDRON, vol. 33, 1977, pages 2725
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H: "Tables of Resolving Agents and Optical Resolutions", 1972, NOTRE DAME UNIVERSITY PRESS, pages: 268
"Remington's Pharmaceutical Sciences", 1990, MACK, EASTON PA
FRIIS, S. D. ET AL.: "Cobalt-Catalysed C–H Methylation for Late-Stage Drug Diversification", NATURE CHEMISTRY, vol. 12, no. 6, 29 May 2020 (2020-05-29), XP037153279, ISSN: 1755-4349, DOI: 10.1038/s41557-020-0475-7
BHOLE RITESH P, NAKSAKHARE SACHIN R, BONDE CHANDRAKANT G: "A Stability Indicating HPTLC Method for Apremilast and Identification of degradation products using MS/MS", JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, CUDDALORE, vol. 11, no. 5, 1 May 2019 (2019-05-01), Cuddalore, pages 1861 - 1869, XP093034686
LOWECHENG, DRUGS OF THE FUTURE, vol. 17, no. 9, 1992, pages 799 - 807
BEAVOREITSNYDER, TRENDS IN PHARM., vol. 11, 1990, pages 150 - 155
VERGHES ET AL., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 272, no. 3, 1995, pages 1313 - 1320
TRACEY ET AL., NATURE, vol. 330, 1987, pages 662 - 664
HINSHAW ET AL., CIRCLE. SHOCK, vol. 30, 1990, pages 279 - 292
MILLAR ET AL., LANCET, vol. 2, 1989, pages 712 - 714
FERRAI-BALIVIERA ET AL., ARCH SURG., vol. 124, 1989, pages 1400 - 1405
BERTOLINI ET AL., NATURE, vol. 319, 1986, pages 516 - 518
PIGNET ET AL., NATURE, vol. 344, 1990, pages 245 - 247
BISSONNETTE ET AL., INFLAMMATION, vol. 13, 1989, pages 329 - 339
BAUGHMAN ET AL., J LAB. LIN. MED., vol. 115, 1990, pages 36 - 42
ELLIOT ET AL., INT. J. PHARMAC., vol. 17, 1995, pages 141 - 145
VON DULLEMEN ET AL., GASTROENTEROLOGY, vol. 109, 1995, pages 129 - 135
LOWE, EXP. OPIN. THER. PATENTS, vol. 8, 1998, pages 1309 - 1332
JACQUES, J. ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY-INTERSCIENCE
WILEN, S.H. ET AL., TETRAHEDRON, vol. 33, 1977, pages 2725
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H: "Tables of Resolving Agents and Optical Resolutions", 1972, NOTRE DAME UNIVERSITY PRESS, pages: 268
"Remington's Pharmaceutical Sciences", 1990, MACK, EASTON PA
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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