Title:
SUBSTITUTED FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160652
Kind Code:
A1
Abstract:
Provided are a substituted fused ring compound represented by formula (I), a pharmaceutical composition thereof, a preparation method therefor and the uses thereof. The compound has a good LRRK2 kinase regulation/inhibition effect, and thus can be used for treating symptoms and diseases related to LRRK2 kinase activity, and can be used for preparing drugs for such symptoms and diseases.
Inventors:
SHAO QING (CN)
HUANG ZHIJIANG (CN)
ZHUO LANG (CN)
HUANG ZHIJIANG (CN)
ZHUO LANG (CN)
Application Number:
PCT/CN2023/078130
Publication Date:
August 31, 2023
Filing Date:
February 24, 2023
Export Citation:
Assignee:
SUZHOU YABAO PHARMACEUTICAL R & D CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61P25/16; A61P25/28; A61P35/00
Domestic Patent References:
| WO2013139882A1 | 2013-09-26 |
Foreign References:
| CN102428084A | 2012-04-25 | |||
| CN103261196A | 2013-08-21 | |||
| US20140288043A1 | 2014-09-25 |
Other References:
SHORE DANIEL G.M., SWEENEY ZACHARY K., BERESFORD ALAN, CHAN BRYAN K., CHEN HUIFEN, DRUMMOND JASON, GILL ANDREW, KLEINHEINZ TRACY, : "Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 29, no. 4, 1 February 2019 (2019-02-01), Amsterdam NL , pages 674 - 680, XP093021231, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2018.10.017
SHORE DANIEL G.M., SWEENEY ZACHARY K., BERESFORD ALAN, CHAN BRYAN K., CHEN HUIFEN, DRUMMOND JASON, GILL ANDREW, KLEINHEINZ TRACY, : "Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 29, no. 4, 1 February 2019 (2019-02-01), Amsterdam NL , pages 674 - 680, XP093021231, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2018.10.017
KHAMOULI SAIDA, BELAIDI SALAH, OUASSAF MEBARKA, LANEZ TOUHAMI, BELAAOUAD SAID, CHTITA SAMIR: "Multi-combined 3D-QSAR, docking molecular and ADMET prediction of 5-azaindazole derivatives as LRRK2 tyrosine kinase inhibitors", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 40, no. 3, 11 February 2022 (2022-02-11), US , pages 1285 - 1298, XP093087194, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1824815
SHORE DANIEL G.M., SWEENEY ZACHARY K., BERESFORD ALAN, CHAN BRYAN K., CHEN HUIFEN, DRUMMOND JASON, GILL ANDREW, KLEINHEINZ TRACY, : "Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 29, no. 4, 1 February 2019 (2019-02-01), Amsterdam NL , pages 674 - 680, XP093021231, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2018.10.017
KHAMOULI SAIDA, BELAIDI SALAH, OUASSAF MEBARKA, LANEZ TOUHAMI, BELAAOUAD SAID, CHTITA SAMIR: "Multi-combined 3D-QSAR, docking molecular and ADMET prediction of 5-azaindazole derivatives as LRRK2 tyrosine kinase inhibitors", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 40, no. 3, 11 February 2022 (2022-02-11), US , pages 1285 - 1298, XP093087194, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1824815
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM et al. (CN)
Download PDF:
Previous Patent: ANTIBODY, AND DRUG CONJUGATE AND USE THEREOF
Next Patent: NON-ARCHED RAINPROOF WATER COLLECTION GREENHOUSE
Next Patent: NON-ARCHED RAINPROOF WATER COLLECTION GREENHOUSE