Title:
STRUCTURED HYDROGEL, AND PREPARATION METHOD FOR HYDROGEL HEART AND VALVES
Document Type and Number:
WIPO Patent Application WO/2023/116060
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of hydrogels, and provides a structured hydrogel, and a preparation method for hydrogel heart and valves. The preparation method of the present invention comprises: providing a photo-curing hydrogel ink; establishing a three-dimensional model, and subjecting the photo-curing hydrogel ink to photo-curing 3D printing to obtain a printed hydrogel; and soaking the printed hydrogel in water to obtain a structured functional hydrogel, wherein the photo-curing hydrogel ink comprises a high-density hydrogen-bond-type unsaturated monomer, a photoinitiator, a dye and a solvent, and the solvent comprises water and dimethyl sulfoxide. In the present invention, a high-density hydrogen-bond-type unsaturated monomer is dissolved in a mixed solvent of dimethyl sulfoxide and water to prepare the photo-curing hydrogel ink, and the printed hydrogel, which results from the photo-curing 3D printing, is soaked in water to enable dimethyl sulfoxide in the printed hydrogel to diffuse into water for phase inversion, such that hydrogen bonds in the printed hydrogel are reconstructed, and ultimately, the toughness of the structured functional hydrogel is improved.
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Inventors:
WANG XIAOLONG (CN)
WU JIAYU (CN)
JIANG PAN (CN)
LU YAOZHONG (CN)
ZHOU FENG (CN)
WU JIAYU (CN)
JIANG PAN (CN)
LU YAOZHONG (CN)
ZHOU FENG (CN)
Application Number:
PCT/CN2022/117682
Publication Date:
June 29, 2023
Filing Date:
September 08, 2022
Export Citation:
Assignee:
LANZHOU INST OF CHEMICAL PHYSICS CAS (CN)
International Classes:
A61L27/16; C08F120/60; A61L27/50; A61L27/52; B33Y70/00; B33Y70/10; C08F220/56; C08F220/60
Foreign References:
| CN114106227A | 2022-03-01 | |||
| CN112521550A | 2021-03-19 | |||
| CN115057970A | 2022-09-16 | |||
| CN112521625A | 2021-03-19 | |||
| CN114805694A | 2022-07-29 | |||
| US5883211A | 1999-03-16 |
Other References:
ZHAI XINYUN, MA YUFEI, HOU CHUNYONG, GAO FEI, ZHANG YINYU, RUAN CHANGSHUN, PAN HAOBO, LU WILLIAM WEIJIA, LIU WENGUANG: "3D-Printed High Strength Bioactive Supramolecular Polymer/Clay Nanocomposite Hydrogel Scaffold for Bone Regeneration", HHS AUTHOR MANUSCRIPTS, vol. 3, no. 6, 12 June 2017 (2017-06-12), US , pages 1109 - 1118, XP055861973, DOI: 10.1021/acsbiomaterials.7b00224
"Introduction to New Functional Materials", 31 October 2014, EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY PRESS CO. LTD., CN, ISBN: 978-7-5628-3449-6, article WANG, JIKUI: "Heparin", pages: 94, XP009547588
FAN CHUANCHUAN, XU ZIYANG, WU TENGLING, CUI CHUNYAN, LIU YANG, LIU BO, YANG JIANHAI, LIU WENGUANG: "3D printing of lubricative stiff supramolecular polymer hydrogels for meniscus replacement", BIOMATERIALS SCIENCE, vol. 9, 1 January 2021 (2021-01-01), GB , pages 5116 - 5126, XP093075148, ISSN: 2047-4830, DOI: 10.1039/D1BM00836F
"Introduction to New Functional Materials", 31 October 2014, EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY PRESS CO. LTD., CN, ISBN: 978-7-5628-3449-6, article WANG, JIKUI: "Heparin", pages: 94, XP009547588
FAN CHUANCHUAN, XU ZIYANG, WU TENGLING, CUI CHUNYAN, LIU YANG, LIU BO, YANG JIANHAI, LIU WENGUANG: "3D printing of lubricative stiff supramolecular polymer hydrogels for meniscus replacement", BIOMATERIALS SCIENCE, vol. 9, 1 January 2021 (2021-01-01), GB , pages 5116 - 5126, XP093075148, ISSN: 2047-4830, DOI: 10.1039/D1BM00836F
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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