Title:
SINGLE CELL SUPER-RESOLUTION PROTEOMICS
Document Type and Number:
WIPO Patent Application WO/2024/044380
Kind Code:
A3
Abstract:
Disclosed are methods for full morphological labeling of individual neurons from any species or cell type for subsequent cell-delineated protein analysis. These methods, which combines patch-clamp electrophysiology with epitope-preserving magnified analysis of proteome (eMAP), additionally allow for correlation of physiological properties with subcellular protein expression.
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Inventors:
HARNETT MARK (US)
VARDALAKI DIMITRA (US)
VARDALAKI DIMITRA (US)
Application Number:
PCT/US2023/031184
Publication Date:
April 04, 2024
Filing Date:
August 25, 2023
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
G01N33/48; A61B5/053; C12N5/0793; G01N33/50
Foreign References:
| US20200054711A1 | 2020-02-20 |
Other References:
COURTNEY E. YAEGER: "A dendritic mechanism for balancing synaptic flexibility and stability", BIORXIV, 9 April 2022 (2022-04-09), XP093159051, Retrieved from the Internet DOI: 10.1101/2022.02.02.478840
Attorney, Agent or Firm:
GORDON, Dana, M. et al. (US)
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