Title:
SARS-COV-2 ANTIGEN POLYPEPTIDE, AND RECOMBINANT ADENO-ASSOCIATED VIRUS THEREOF AND USE THEREOF IN PREPARATION OF VACCINE
Document Type and Number:
WIPO Patent Application WO/2024/055429
Kind Code:
A1
Abstract:
Disclosed in the present invention are an SARS-COV-2 antigen polypeptide, a recombinant adeno-associated virus and the use thereof. The present invention uses an S protein or RBD of the SARS-COV-2 antigen polypeptide as an antigen. A truncated domain has a shorter sequence length, a smaller molecular weight and a clearer structure, and has specificity. The recombinant adeno-associated virus, which contains a nucleic acid sequence encoding the antigen polypeptide achieves gene delivery via intramuscular injection and can effectively and continuously express the antigen polypeptide. The antigen polypeptide, which is expressed by the recombinant adeno-associated virus of the present invention in vivo, can induce a specific immune response against the SARS-COV-2 antigen polypeptide, and an antibody serum produced thereby can not only specifically recognize the SARS-COV-2 RBD antigen polypeptide, but also has a neutralizing titer, and can inhibit the replication and transmission of variant strains Delta and Omicron or prevent the variant strains Delta and Omicron from settling in a host, thereby effectively preventing and/or treating COVID-19 caused by SARS-CoV-2.
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Inventors:
LI ZHANRU (CN)
Application Number:
PCT/CN2022/133918
Publication Date:
March 21, 2024
Filing Date:
November 24, 2022
Export Citation:
Assignee:
GUANGDONG HENGDA BIOMEDICAL TECH CO LTD (CN)
GUANGZHOU NAT LABORATORY (CN)
GUANGZHOU NAT LABORATORY (CN)
International Classes:
C07K14/165; A61K39/215; A61K39/295; A61P11/00; A61P31/14; C12N15/50; C12N15/62; C12N15/864
Foreign References:
| CN113185613A | 2021-07-30 | |||
| CN113480618A | 2021-10-08 | |||
| CN113388041A | 2021-09-14 | |||
| CN113321739A | 2021-08-31 | |||
| CN113913464A | 2022-01-11 |
Other References:
DATABASE Protein ANONYMOUS : "Delta Spike GPdelta [synthetic construct] ", XP093148640, retrieved from NCBI
DATABASE Protein ANONYMOUS : "Delta Spike GPdelta [synthetic construct] ", XP093148643, retrieved from NCBI
DATABASE Protein ANONYMOUS : "Delta Spike GPdelta [synthetic construct] ", XP093148643, retrieved from NCBI
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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