Title:
REFINEMENT METHOD FOR POLYETHYLENE GLYCOL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/132124
Kind Code:
A1
Abstract:
A refinement method for a polyethylene glycol compound indicated by formula [1], characterized having a step (A) and a step (B). Step (A): A step in which a solution is obtained by dissolving a compound indicated by formula [1] in an organic solvent having a Hildebrand solubility parameter of 8–10 (cal/cm3)1/2.
Step (B): A step in which a slurry is prepared by mixing, into the solution, 0.1–1 parts by mass of an adsorbent comprising a hydrotalcite having a specific surface area of 50–200 m2/g, relative to 1 part by mass of the compound indicated by formula [1].
(In formula [1]: Z indicates a residue obtained by removing an active hydrogen group from a compound having 2-5 active hydrogen groups; A indicates an amino group; Y1 and Y2 each independently indicate an ether bond, an amide bond, an ester bond, a urethane bond, a carbonate bond, a secondary amino group, a thioether bond, a disulfide bond, a thioester bond, or an alkylene group including these; "Polymer" indicates a polyethylene glycol chain; X indicates a C1–7 hydrocarbon group, a C3–9 acetal group, a hydroxy group, a hydroxy group protecting group, a carboxyl group, a carboxyl group protecting group, a thiol group, a thiol group protecting group, a cyano group, or an alkylene group including these; l = 1 or 0; m = 1 or 0; and a and b are integers that fulfill 0≤a≤4, 0≤b≤4, and 1≤a+b≤4.)
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Inventors:
KAWAHARA RYO (JP)
SATO ATSUSHI (JP)
HIRAI MIDORI (JP)
TAKEUCHI KYU (JP)
SATO ATSUSHI (JP)
HIRAI MIDORI (JP)
TAKEUCHI KYU (JP)
Application Number:
PCT/JP2020/047604
Publication Date:
July 01, 2021
Filing Date:
December 21, 2020
Export Citation:
Assignee:
NOF CORP (JP)
International Classes:
C08G65/30
Domestic Patent References:
WO2012086016A1 | 2012-06-28 |
Foreign References:
JP2004197077A | 2004-07-15 | |||
JP2010248504A | 2010-11-04 | |||
JP2002363278A | 2002-12-18 | |||
JP2010254978A | 2010-11-11 | |||
JPH08165343A | 1996-06-25 | |||
JP2014208786A | 2014-11-06 | |||
JP2010254978A | 2010-11-11 | |||
JP2011079934A | 2011-04-21 | |||
JP2019237880A | 2019-12-27 |
Other References:
See also references of EP 4083108A4
Attorney, Agent or Firm:
KOH-EI PATENT FIRM, P.C. (JP)
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