Title:
RECOMBINANT FUSION PROTEIN E35 SPECIFIC TO MYCOBACTERIUM TUBERCULOSIS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/179592
Kind Code:
A1
Abstract:
Provided is a recombinant fusion protein E35 specific to Mycobacterium tuberculosis, which comprises a protein ESAT6 and a protein PE35, and can sensitively and specifically detect Mycobacterium tuberculosis infections and can effectively distinguish Mycobacterium tuberculosis infections from the inoculation of a Bacillus Calmette-Guérin vaccine. A Mycobacterium tuberculosis infection detection reagent developed by means of using the recombinant fusion protein can have the specificity of IGRA detection, the sensitivity of traditional TST detection and the simplicity and convenience of adapting to large-scale screening, and can be used for performing LTBI screening and diagnosis.
Inventors:
ZHAO YANLIN (CN)
LIU ERYONG (CN)
GUO SHOUJIE (CN)
ZHU BINGQING (CN)
LIU CHUNFA (CN)
WANG YANRU (CN)
LIU ERYONG (CN)
GUO SHOUJIE (CN)
ZHU BINGQING (CN)
LIU CHUNFA (CN)
WANG YANRU (CN)
Application Number:
PCT/CN2023/082738
Publication Date:
September 28, 2023
Filing Date:
March 21, 2023
Export Citation:
Assignee:
A & B BIOTECHNOLOGY LTD BEIJING (CN)
A & B BIOTECHNOLOGY LTD SUZHOU (CN)
A & B BIOTECHNOLOGY LTD SUZHOU (CN)
International Classes:
C07K19/00; C12N1/21; C12N15/62; C12N15/70; G01N33/569
Foreign References:
| CN101538578A | 2009-09-23 | |||
| CN113045677A | 2021-06-29 | |||
| CN105218678A | 2016-01-06 | |||
| CN106232138A | 2016-12-14 | |||
| CN110423279A | 2019-11-08 | |||
| CN113980145A | 2022-01-28 |
Attorney, Agent or Firm:
LEADING INTELLECTUAL PROPERTY FIRM (CN)
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