Title:
RECOMBINANT CELL, METHOD FOR PRODUCING RECOMBINANT CELL, AND METHOD FOR PRODUCING ORGANIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/094053
Kind Code:
A1
Abstract:
A recombinant cell characterized by: having a function of synthesizing acetyl-CoA from methyltetrahydrofolic acid, carbon monoxide and CoA; carrying a gene that expresses an exogenous NAD(P)H consumption pathway, said gene being expressed in the recombinant cell; the expression of at least one endogenous NAD(P)H consumption pathway held by the recombinant cell being down-regulated, said endogenous NAD(P)H consumption pathway being different from the exogenous NAD(P)H consumption pathway; and being capable of producing an organic compound having four or more carbon atoms, through the exogenous NAD(P)H consumption pathway, from at least one member selected from the group consisting of carbon monoxide and carbon dioxide.
Inventors:
FURUTANI MASAHIRO (JP)
NISHIYAMA NORIHIDE (JP)
KAWABATA KAZUFUMI (JP)
NISHIYAMA NORIHIDE (JP)
KAWABATA KAZUFUMI (JP)
Application Number:
PCT/JP2015/083545
Publication Date:
June 08, 2017
Filing Date:
November 30, 2015
Export Citation:
Assignee:
SEKISUI CHEMICAL CO LTD (JP)
International Classes:
C12N15/00; C12N1/21; C12P5/00; C12P5/02
Domestic Patent References:
| WO2014065271A1 | 2014-05-01 | |||
| WO2014156476A1 | 2014-10-02 |
Foreign References:
| JP2015181428A | 2015-10-22 | |||
| JP2014161252A | 2014-09-08 |
Other References:
SHUN'ICHI NAKAYAMA: "Homo-Butanol Hakko eno Chosen", JOURNAL OF THE SOCIETY FOR BIOSCIENCE AND BIOENGINEERING, vol. 89, no. 8, 2011, Japan, pages 499, XP009506406
SHEN, C.R. ET AL.: "Driving Forces Enable High- Titer Anaerobic 1-Butanol Synthesis in Escherichia coli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 77, no. 9, 2011, pages 2905 - 2915, XP055031453
MASAHARU MUKOYAMA ET AL.: "Koshuritsu . Koseisan-gata Homo-Butanol Seisan Kin o Mezashita Clostridium-zoku Biseibutsu no Ikushu", THE 2014TH PROCEEDINGS ( ONLINE ) OF THE ANNUAL MEETING OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 5 March 2014 (2014-03-05), XP009506563
LEANG, C. ET AL.: "A Genetic System for Clostridium ljungdahlii: a Chassis for Autotrophic Production of Biocommodities and a Model Homoacetogen", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 79, no. 4, 2013, pages 1102 - 1109, XP055110483
See also references of EP 3385378A4
SHEN, C.R. ET AL.: "Driving Forces Enable High- Titer Anaerobic 1-Butanol Synthesis in Escherichia coli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 77, no. 9, 2011, pages 2905 - 2915, XP055031453
MASAHARU MUKOYAMA ET AL.: "Koshuritsu . Koseisan-gata Homo-Butanol Seisan Kin o Mezashita Clostridium-zoku Biseibutsu no Ikushu", THE 2014TH PROCEEDINGS ( ONLINE ) OF THE ANNUAL MEETING OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 5 March 2014 (2014-03-05), XP009506563
LEANG, C. ET AL.: "A Genetic System for Clostridium ljungdahlii: a Chassis for Autotrophic Production of Biocommodities and a Model Homoacetogen", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 79, no. 4, 2013, pages 1102 - 1109, XP055110483
See also references of EP 3385378A4
Attorney, Agent or Firm:
FUJITA Takashi et al. (JP)
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