Title:
RADIOACTIVE EVANS BLUE DERIVATIVE PHARMACEUTICAL AQUEOUS SOLUTION, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/202730
Kind Code:
A3
Abstract:
The present application relates to a radiopharmaceutical aqueous solution and a use thereof. The radiopharmaceutical aqueous solution comprises a complex formed by a targeting molecule modified by an Evans blue (EB) fragment and a radioactive metal nuclide, as well as a stabilizer, the stabilizer preferably being one or two or more among gentisic acid, ethanol, and methionine.
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Inventors:
YANG GUOGUI (CN)
HAO JIN (CN)
DU ZETIAN (CN)
TIAN JIALE (CN)
HAO JIN (CN)
DU ZETIAN (CN)
TIAN JIALE (CN)
Application Number:
PCT/CN2023/101452
Publication Date:
December 14, 2023
Filing Date:
June 20, 2023
Export Citation:
Assignee:
SINOTAU PHARMACEUTICALS GROUP (CN)
International Classes:
A61K51/04; A61K51/08; A61K51/12; A61P35/00
Domestic Patent References:
| WO2020021310A1 | 2020-01-30 |
Foreign References:
| CN114748471A | 2022-07-15 | |||
| CN114796532A | 2022-07-29 | |||
| CN111542518A | 2020-08-14 |
Other References:
WANG, ZHANTONG ET AL.: "Single Low-Dose Injection of Evans Blue Modified PSMA-617 Radioligand Therapy Eliminates Prostate-Specific Membrane Antigen Positive Tumors", BIOCONJUGATE CHEMISTRY, vol. 29, 14 August 2018 (2018-08-14), pages 3213 - 3221, XP055849080, DOI: 10.1021/acs.bioconjchem.8b00556
WEN XUEJUN, XU PENGFEI, SHI MENGQI, LIU JIA, ZENG XINYING, ZHANG YIREN, SHI CHANGRONG, LI JINGCHAO, GUO ZHIDE, ZHANG XIANZHONG, KH: "Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 12, no. 1, 1 January 2022 (2022-01-01), AU , pages 422 - 433, XP093117064, ISSN: 1838-7640, DOI: 10.7150/thno.68182
DE BLOIS ERIK, CHAN HO SZE, DE ZANGER RORY, KONIJNENBERG MARK, BREEMAN WOUTER A.P.: "Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD., GB, vol. 85, 1 February 2014 (2014-02-01), GB , pages 28 - 33, XP093117067, ISSN: 0969-8043, DOI: 10.1016/j.apradiso.2013.10.023
WEN XUEJUN, XU PENGFEI, SHI MENGQI, LIU JIA, ZENG XINYING, ZHANG YIREN, SHI CHANGRONG, LI JINGCHAO, GUO ZHIDE, ZHANG XIANZHONG, KH: "Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 12, no. 1, 1 January 2022 (2022-01-01), AU , pages 422 - 433, XP093117064, ISSN: 1838-7640, DOI: 10.7150/thno.68182
DE BLOIS ERIK, CHAN HO SZE, DE ZANGER RORY, KONIJNENBERG MARK, BREEMAN WOUTER A.P.: "Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD., GB, vol. 85, 1 February 2014 (2014-02-01), GB , pages 28 - 33, XP093117067, ISSN: 0969-8043, DOI: 10.1016/j.apradiso.2013.10.023
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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