Title:
PTMC-BASED INTESTINAL ANASTOMOSIS STENT OF BIOABSORBABLE FLEXIBLE ELASTOMER AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/228356
Kind Code:
A1
Abstract:
A PTMC-based intestinal anastomosis stent of a bioabsorbable flexible elastomer and a preparation method therefor. The intestinal anastomosis stent that uses PTMC as a base material is prepared by using an electrostatic spinning method, and an appropriate range suitable for being implanted into the body is screened out according to degradation rate and mechanical property. A PTMC homopolymer loading material of the stent is loaded with triclosan TCS having a bactericidal effect, so that the stent has a tissue repair adjustment function, enabling a wound to heal more quickly in a severe multi-bacterial intestinal environment, and for adjusting postoperative tissue healing and functional repair. An in-vivo animal intestinal anastomosis experiment is carried out, thus verifying the practical effects and the feasibility of the method.
Inventors:
SHI CHANGCAN (CN)
LI XUJIAN (CN)
JI ZHIXIAO (CN)
PAN LUQI (CN)
YANG XIAO (CN)
JIANG DAWEI (CN)
LI XUJIAN (CN)
JI ZHIXIAO (CN)
PAN LUQI (CN)
YANG XIAO (CN)
JIANG DAWEI (CN)
Application Number:
PCT/CN2022/088873
Publication Date:
November 03, 2022
Filing Date:
April 25, 2022
Export Citation:
Assignee:
WENZHOU INSTITUTE UNIV OF CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61F2/04; A61L31/06; D01D5/00
Foreign References:
| CN113288505A | 2021-08-24 | |||
| CN113413491A | 2021-09-21 | |||
| CN101133973A | 2008-03-05 | |||
| DE19926008A1 | 2000-12-14 | |||
| CN108577916A | 2018-09-28 | |||
| CN105944153A | 2016-09-21 | |||
| CN109966567A | 2019-07-05 | |||
| US20100298928A1 | 2010-11-25 | |||
| CN102989044A | 2013-03-27 |
Other References:
AJIRO HIROHARU; HARAMIISHI YOSHIAKI; CHANTHASET NALINTHIP; AKASHI MITSURU: "Polymer design using trimethylene carbonate with ethylene glycol units for biomedical applications", POLYMER JOURNAL, NATURE PUBLISHING GROUP UK, LONDON, vol. 48, no. 7, 1 January 1900 (1900-01-01), London , pages 751 - 760, XP037325147, ISSN: 0032-3896, DOI: 10.1038/pj.2016.35
Attorney, Agent or Firm:
WENZHOU JINOU PATENT LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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