Title:
PROTEIN-BASED MATERIAL FOR RECOVERY AND SEPARATION OF TRANSITION METALS
Document Type and Number:
WIPO Patent Application WO/2024/036235
Kind Code:
A3
Abstract:
Provided are proteins and protein-based sensors for detecting MnII. The proteins may have the following sequence: Z1-MPTTTTKVDIAAFDPDKDGTIHLKDALAAGSAAFDKLDPDKDGTLHAKDLKGRVSEADLKKLDPDX1DGTLHKKDYLAAVEAQFKAAX2PDNDGTIX3ARX4LASPAGSALVNLIR-X5-Z2 (SEQ ID NO:1), where Z1 and Z2 correspond to a FRET pair, X1 is N or G, X2 is N or D, X3 is D or H, X4 is E or D, and X5 is optional and is the sequence GSGC (SEQ ID NO:40) and when X5 is present, then Z1 and Z2 are absent. Z1 and Z2 are optional. Also provided are methods of using the proteins to detect and separate MnII. Also provided are compositions, kits, and devices.
Inventors:
COTRUVO JR (US)
PARK JENNIFER (US)
PARK JENNIFER (US)
Application Number:
PCT/US2023/071963
Publication Date:
May 10, 2024
Filing Date:
August 09, 2023
Export Citation:
Assignee:
PENN STATE RES FOUND (US)
International Classes:
G01N33/50; A61K45/06; G01N21/64
Attorney, Agent or Firm:
DIMAIO, John et al. (US)
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