Title:
POLYPEPTIDE-ENCODED LIBRARY AND SCREENING METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/232058
Kind Code:
A3
Abstract:
Provided is a polypeptide-encoded nucleic acid or small molecule compound library. The library comprises polypeptide barcode tags and nucleic acid molecules or small molecule compounds corresponding to the polypeptide barcode tags. Further provided is a polypeptide-encoded nucleic acid or small molecule compound library, the library comprising a plurality of beads, and each bead comprising a polypeptide barcode tag connected to the bead and a nucleic acid molecule or a small molecule compound corresponding to the polypeptide barcode tag. Further provided is a method for screening a target nucleic acid or small molecule via the polypeptide-encoded nucleic acid or small molecule compound library, wherein a screened nucleic acid molecule or small molecule compound is identified by decoding a polypeptide barcode tag associated therewith.
Inventors:
ZHAO HAIFENG (CN)
Application Number:
PCT/CN2023/097328
Publication Date:
January 25, 2024
Filing Date:
May 31, 2023
Export Citation:
Assignee:
MEDSPRING INT LTD (CN)
International Classes:
C40B40/00; C40B30/04; C40B30/06; C40B70/00
Foreign References:
| US20180284125A1 | 2018-10-04 | |||
| US20040235054A1 | 2004-11-25 |
Other References:
LIU R, MARIK J, LAM K S: "A novel peptide-based encoding system for 'one-bead one-compound' peptidomimetic and small molecule combinatorial libraries", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 124, no. 26, 1 January 2002 (2002-01-01), pages 7678 - 7680, XP002976669, ISSN: 0002-7863, DOI: 10.1021/ja026421t
LIU R, MARIK J, LAM K S: "A novel peptide-based encoding system for 'one-bead one-compound' peptidomimetic and small molecule combinatorial libraries", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 124, no. 26, 1 January 2002 (2002-01-01), pages 7678 - 7680, XP002976669, ISSN: 0002-7863, DOI: 10.1021/ja026421t
KERR, J. M. ET AL.: "Encoded combinatorial peptide libraries containing non- natural amino acids", J. AM. CHEM. SOC., vol. 115, no. 6, 1 March 1993 (1993-03-01), pages 2529 - 2531, XP002128603, DOI: 10.1021/ja00059a070
LIU R, MARIK J, LAM K S: "A novel peptide-based encoding system for 'one-bead one-compound' peptidomimetic and small molecule combinatorial libraries", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 124, no. 26, 1 January 2002 (2002-01-01), pages 7678 - 7680, XP002976669, ISSN: 0002-7863, DOI: 10.1021/ja026421t
KERR, J. M. ET AL.: "Encoded combinatorial peptide libraries containing non- natural amino acids", J. AM. CHEM. SOC., vol. 115, no. 6, 1 March 1993 (1993-03-01), pages 2529 - 2531, XP002128603, DOI: 10.1021/ja00059a070
Attorney, Agent or Firm:
SPREADWINGS INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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